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anti-IL23R antibody :: Rabbit anti-Human, Mouse IL23R Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7050433
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL23R, Polyclonal Antibody

★Popular Item★
 Also Known As   

IL23R Antibody

 Product Synonym Names    Interleukin-23 receptorIL-23 receptorIL-23R; IL23R
 Product Gene Name   

anti-IL23R antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    AF461422 mRNA
 3D Structure    ModBase 3D Structure for Q5VWK5
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Immunogen    Recombinant Human Interleukin-23 receptor protein (15-125AA)
 Preservative    0.03% Proclin 300
 Constituents    50% Glycerol, 0.01M PBS, PH 7.4
 Conjugation    Non-conjugated
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-47060 / sc-47062 / sc-47063 / sc-99030
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-IL23R antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL23R antibody

   Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
 Applications Tested/Suitable for anti-IL23R antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-IL23R antibody    WB: 1: 500-1: 5000
IHC: 1: 20-1: 200
IF: 1: 50-1: 200
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 Western Blot (WB) of anti-IL23R antibody    Western Blot
Positive WB detected in:NIH/3T3 whole cell lysate,K562 whole cell lysate,Mouse liver tissue,Mouse lung tissue,Mouse spleen tissue
All lanes: IL23R antibody at 3.4ug/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 72,43,41,21,31,26 kDa
Observed band size: 72 kDa

anti-IL23R antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-IL23R antibody    Immunohistochemistry of paraffin-embedded human tonsil tissue using MBS7050433 at dilution of 1:100
anti-IL23R antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-IL23R antibody    Immunohistochemistry of paraffin-embedded human kidney tissue using MBS7050433 at dilution of 1:100
anti-IL23R antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-IL23R antibody    Immunofluorescent analysis of MCF-7 cells using MBS7050433 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-IL23R antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for IL23R. It may not necessarily be applicable to this product.
 NCBI GI #    24430212
 NCBI GeneID    149233
 NCBI Accession #    NP_653302.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_144701.2 [Other Products]
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 UniProt Primary Accession #    Q5VWK5 [Other Products]
 UniProt Secondary Accession #    Q4VGP1; Q4VGP2; Q4VGP3; Q4VGP4; Q4VGP5; Q4VGP6; Q5VWK7; Q8IW84; Q8NFQ9; Q96AS1; C9JGX4 [Other Products]
 UniProt Related Accession #    Q5VWK5 [Other Products]
 Molecular Weight    25,551 Da
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 NCBI Official Full Name    interleukin-23 receptor
 NCBI Official Synonym Full Names    interleukin 23 receptor
 NCBI Official Symbol    IL23R [Similar Products]
 NCBI Protein Information    interleukin-23 receptor
 UniProt Protein Name    Interleukin-23 receptor
 Protein Family    Interleukin-23 receptor
 UniProt Gene Name    IL23R [Similar Products]
 UniProt Synonym Gene Names    IL-23 receptor; IL-23R [Similar Products]
 UniProt Entry Name    IL23R_HUMAN
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 NCBI Summary for IL23R    The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL23R    IL23R: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. Genetic variations in IL23R are associated with inflammatory bowel disease type 17 (IBD17). IBD17 is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Genetic variations in IL23R are a cause of susceptibility to psoriasis type 7 (PSORS7). Psoriasis is a common, chronic inflammatory disease of the skin with multifactorial etiology. It is characterized by red, scaly plaques usually found on the scalp, elbows and knees. These lesions are caused by abnormal keratinocyte proliferation and infiltration of inflammatory cells into the dermis and epidermis. Belongs to the type I cytokine receptor family. Type 2 subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: plasma membrane; receptor complex

Molecular Function: interleukin-12 receptor binding; interleukin-23 binding; interleukin-23 receptor activity; protein binding

Biological Process: defense response to Gram-negative bacterium; negative regulation of interleukin-10 production; positive regulation of activated T cell proliferation; positive regulation of defense response to virus by host; positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of interferon-gamma production; positive regulation of interleukin-12 production; positive regulation of interleukin-17 production; positive regulation of memory T cell differentiation; positive regulation of natural killer cell proliferation; positive regulation of NK T cell activation; positive regulation of osteoclast differentiation; positive regulation of T cell mediated cytotoxicity; positive regulation of T cell proliferation; positive regulation of T-helper 1 type immune response; positive regulation of tyrosine phosphorylation of Stat3 protein; positive regulation of tyrosine phosphorylation of Stat4 protein; positive regulation of tyrosine phosphorylation of Stat5 protein; regulation of tyrosine phosphorylation of Stat1 protein; response to lipopolysaccharide

Disease: Inflammatory Bowel Disease 17; Psoriasis 7, Susceptibility To
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 Research Articles on IL23R    1. These results suggest that IL23R may contribute to the development of intracerebral hemorrhage.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL23R antibodyPathways associated with anti-IL23R antibody
 Reference Product  PubMed Publications
 STAT3 antibody  >53 publications with IL23R and STAT3
 IL23A antibody  >33 publications with IL23R and IL23A
 STAT4 antibody  >27 publications with IL23R and STAT4
 JAK2 antibody  >23 publications with IL23R and JAK2
 IL12RB1 antibody  >21 publications with IL23R and IL12RB1
 TYK2 antibody  >13 publications with IL23R and TYK2
 STAT1 antibody  >11 publications with IL23R and STAT1
 IL1B antibody  >5 publications with IL23R and IL1B
 IL19 antibody  >2 publications with IL23R and IL19
 STAT5A antibody  >2 publications with IL23R and STAT5A
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram
 Interleukin-4 And 13 Signaling Pathway antibodies  Interleukin-4 And 13 Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
Diseases associated with anti-IL23R antibodyOrgans/Tissues associated with anti-IL23R antibody
 Disease Name  Pubmed Publications
 Inflammatory Bowel Diseases Antibodies  >225 publications with IL23R and Inflammatory Bowel Diseases
 Crohn Disease Antibodies  >148 publications with IL23R and Crohn Disease
 Autoimmune Diseases Antibodies  >128 publications with IL23R and Autoimmune Diseases
 Colitis, Ulcerative Antibodies  >114 publications with IL23R and Colitis, Ulcerative
 Psoriasis Antibodies  >109 publications with IL23R and Psoriasis
 Inflammation Antibodies  >101 publications with IL23R and Inflammation
 Bone Diseases Antibodies  >79 publications with IL23R and Bone Diseases
 Spondylitis, Ankylosing Antibodies  >63 publications with IL23R and Spondylitis, Ankylosing
 Inflammatory Bowel Disease 17 Antibodies  >51 publications with IL23R and Inflammatory Bowel Disease 17
 Necrosis Antibodies  >41 publications with IL23R and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >50 publications with IL23R and Skin
 Bone Marrow Antibodies  >7 publications with IL23R and Bone Marrow
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