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anti-IL5 antibody :: Rabbit IL5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9128390
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IL5, Polyclonal Antibody

★Popular Item★
 Also Known As   

IL5 Polyclonal Antibody

 Product Gene Name   

anti-IL5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147850
 3D Structure    ModBase 3D Structure for P05113
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
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 Immunogen    Recombinant funsion protein containing a sequence Corresponsding to amino acids 20-134 of human IL5.
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 Preparation and Storage    Store at -20 degree C. Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-IL5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IL5 antibody

   This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2. This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
 Applications Tested/Suitable for anti-IL5 antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-IL5 antibody    WB 1:500 - 1:2000
IHC 1:50 - 1:100
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 Western Blot (WB) of anti-IL5 antibody    Western blot analysis of extracts of various cell lines, using IL5 antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 15s.
anti-IL5 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-IL5 antibody    Immunohistochemistry of paraffin-embedded human liver using IL5 antibody at dilution of 1:100 (40x lens).
anti-IL5 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-IL5 antibody    Immunohistochemistry of paraffin-embedded human stomach using IL5 antibody at dilution of 1:100 (40x lens).
anti-IL5 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for IL5. It may not necessarily be applicable to this product.
 NCBI GI #    4504671
 NCBI GeneID    3567
 NCBI Accession #    NP_000870.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000879.2 [Other Products]
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 UniProt Primary Accession #    P05113 [Other Products]
 UniProt Secondary Accession #    Q13840 [Other Products]
 UniProt Related Accession #    P05113 [Other Products]
 Molecular Weight    15kDa
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 NCBI Official Full Name    interleukin-5
 NCBI Official Synonym Full Names    interleukin 5
 NCBI Official Symbol    IL5 [Similar Products]
 NCBI Official Synonym Symbols   
EDF; TRF; IL-5
[Similar Products]
 NCBI Protein Information    interleukin-5
 UniProt Protein Name    Interleukin-5
 UniProt Synonym Protein Names   
B-cell differentiation factor I; Eosinophil differentiation factor; T-cell replacing factor; TRF
 Protein Family    Interleukin
 UniProt Gene Name    IL5 [Similar Products]
 UniProt Synonym Gene Names    IL-5; TRF [Similar Products]
 UniProt Entry Name    IL5_HUMAN
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 NCBI Summary for IL5    This gene encodes a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. The encoded cytokine plays a major role in the regulation of eosinophil formation, maturation, recruitment and survival. The increased production of this cytokine may be related to pathogenesis of eosinophil-dependent inflammatory diseases. This cytokine functions by binding to its receptor, which is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene is located on chromosome 5 within a cytokine gene cluster which includes interleukin 4 (IL4), interleukin 13 (IL13), and CSF2 . This gene, IL4, and IL13 may be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31. [provided by RefSeq, Jul 2013]
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 UniProt Comments for IL5    IL5: Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. Belongs to the IL-5 family.

Protein type: Secreted, signal peptide; Cytokine; Secreted

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; interleukin-5 receptor binding; growth factor activity; cytokine activity

Biological Process: positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of B cell proliferation; positive regulation of JAK-STAT cascade; immune response; positive regulation of transcription factor activity; positive regulation of immunoglobulin secretion; inflammatory response; positive regulation of eosinophil differentiation
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 Research Articles on IL5    1. At a fixed concentration of 10-10 M, FF had significantly higher suppressive effects on interferon (IFN)-gamma, interleukin (IL)-2 and IL-17 release, but not IL-5 or tumor necrosis factor (TNF)-alpha, vs. MF.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL5 antibodyPathways associated with anti-IL5 antibody
 Reference Product  PubMed Publications
 IL4 antibody  >226 publications with IL5 and IL4
 IL2 antibody  >103 publications with IL5 and IL2
 IL3 antibody  >50 publications with IL5 and IL3
 JUN antibody  >39 publications with IL5 and JUN
 IL9 antibody  >26 publications with IL5 and IL9
 IL5RA antibody  >26 publications with IL5 and IL5RA
 GATA3 antibody  >23 publications with IL5 and GATA3
 STAT6 antibody  >9 publications with IL5 and STAT6
 CSF2RB antibody  >5 publications with IL5 and CSF2RB
 Products by Pathway  Pathway Diagram
 ARMS-mediated Activation Pathway antibodies  ARMS-mediated Activation Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Autoimmune Thyroid Disease Pathway antibodies  Autoimmune Thyroid Disease Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway antibodies  Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway Diagram
Diseases associated with anti-IL5 antibodyOrgans/Tissues associated with anti-IL5 antibody
 Disease Name  Pubmed Publications
 Hypersensitivity Antibodies  >139 publications with IL5 and Hypersensitivity
 Inflammation Antibodies  >124 publications with IL5 and Inflammation
 Asthma Antibodies  >122 publications with IL5 and Asthma
 Lung Diseases Antibodies  >97 publications with IL5 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >96 publications with IL5 and Respiratory Hypersensitivity
 Eosinophilia Antibodies  >74 publications with IL5 and Eosinophilia
 Necrosis Antibodies  >64 publications with IL5 and Necrosis
 Fibrosis Antibodies  >14 publications with IL5 and Fibrosis
 Hyperplasia Antibodies  >13 publications with IL5 and Hyperplasia
 Bronchial Hyperreactivity Antibodies  >13 publications with IL5 and Bronchial Hyperreactivity
 Organ/Tissue Name  Pubmed Publications
 Thymus Antibodies  >9 publications with IL5 and Thymus
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