NP_006537.3
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NCBI GenBank Nucleotide #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
insulin-like growth factor 2 mRNA-binding protein 1 isoform 1
NCBI Official Synonym Full Names
insulin like growth factor 2 mRNA binding protein 1
NCBI Official Synonym Symbols
IMP1; ZBP1; CRDBP; IMP-1; CRD-BP; VICKZ1 [Similar Products]
NCBI Protein Information
insulin-like growth factor 2 mRNA-binding protein 1
UniProt Protein Name
Insulin-like growth factor 2 mRNA-binding protein 1
UniProt Synonym Protein Names
Coding region determinant-binding protein; CRD-BP; IGF-II mRNA-binding protein 1; VICKZ family member 1; Zipcode-binding protein 1; ZBP-1
UniProt Synonym Gene Names
CRDBP; VICKZ1; ZBP1; IGF2 mRNA-binding protein 1; IMP-1; IMP1; CRD-BP; ZBP-1 [Similar Products]
UniProt Entry Name
IF2B1_HUMAN
NCBI Summary for IGF2BP1
This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
UniProt Comments for IGF2BP1
IGF2BP1: a conserved trans-acting factor that can control translation of specific mRNAs in vivo. Contains four K homology (KH) domains and two RNA recognition motifs. It functions by binding to the 5' UTR of the target mRNAs and repressing translation. Target mRNAs include those encoding beta-actin and insulin-like growth factor 2 (IGF2). Tyrosine phosphorylation apparently abolishes translational repression of actin expression by decreasing its binding beta-actin mRNA. May have a role in progression of ovarian cancer. Contains nuclear export signals within the RNA-binding KH2 and KH4 domains. Aberrant expression may interfere with c-myc regulation.
Protein type: Translation; RNA-binding
Chromosomal Location of Human Ortholog: 17q21.32
Cellular Component: axon; cytoplasm; cytosol; dendritic spine; filopodium; growth cone; lamellipodium; nucleus; perinuclear region of cytoplasm; ribonucleoprotein complex; stress granule
Molecular Function: mRNA 3'-UTR binding; mRNA 5'-UTR binding; mRNA binding; nucleotide binding; protein binding; translation regulator activity
Biological Process: gene expression; mRNA transport; negative regulation of translation; pallium cell proliferation in the forebrain; regulation of cytokine biosynthetic process
Research Articles on IGF2BP1
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Products associated with anti-IGF2BP1 antibody
Pathways associated with anti-IGF2BP1 antibody
Diseases associated with anti-IGF2BP1 antibody
Organs/Tissues associated with anti-IGF2BP1 antibody
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