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anti-INADL antibody :: Goat INADL/PATJ Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421226
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

INADL/PATJ, Polyclonal Antibody

 Also Known As   

Goat anti-INADL/PATJ Antibody

 Product Synonym Names    INADL; PATJ; PDZ domain protein (Drosophila inaD-like); protein associated to tight junctions; InaD-like (Drosophila); RP4-537K17.1; Cipp; FLJ26982; InaD-like; InaD-like; PALS1-associated tight junction protein; PDZ domain protein; channel-interacting PDZ; INADL antibody; PATJ antibody; PDZ domain protein (Drosophila inaD-like) antibody; protein associated to tight junctions antibody; InaD-like (Drosophila) antibody; RP4-537K17.1 antibody; Cipp antibody; FLJ26982 antibody; InaD-like antibody; InaD-like antibody; PALS1-associated tight junction protein antibody; PDZ domain protein antibody; channel-interacting PDZ domain protein antibody; inactivation no after-potential D-like protein antibody; INADL / PATJ
 Product Gene Name   

anti-INADL antibody

[Similar Products]
 Product Synonym Gene Name    PATJ [Similar Products]
 Antibody/Peptide Pairs    INADL / PATJ peptide (MBS425773) is used for blocking the activity of INADL/PATJ antibody (MBS421226)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    PENPATDKLQ VLQ
 OMIM    603199
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human, Dog, Pig, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence PENPATDKLQVLQ-C, from the N Terminus of the protein sequence according to NP_795352.2.
 Epitope    N Terminus
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-INADL antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-INADL antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-INADL antibody    Peptide ELISA: Antibody detection limit dilution 1: 32000.
Immunohistochemistry: In paraffin embedded Human Testis shows strong staining of spermatids. Recommended concentration, 3-6ug/ml.
Western Blot: Preliminary experiments in Human Brain and Kidney lysates consistently showed a strong band at 100kDa followed by bands at ~55kDa, 45kDa and 40kDa at 1ug/ml. Please note that currently we cannot find an explanation in the literature for the bands we observe given the predicted size of approx.196Kda according to NP_795352.2.
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 Immunohistochemistry (IHC) of anti-INADL antibody    (3.8ug/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-INADL antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for INADL. It may not necessarily be applicable to this product.
 NCBI GI #    112382257
 NCBI GeneID    10207
 NCBI Accession #    NP_795352.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_176877.2 [Other Products]
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 UniProt Secondary Accession #    O15249; O43742; O60833; Q5VUA5; Q5VUA6; Q5VUA7; Q5VUA8; Q5VUA9; Q5VUB0; Q8WU78; Q9H3N9 [Other Products]
 UniProt Related Accession #    Q8NI35 [Other Products]
 Molecular Weight    125,231 Da
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 NCBI Official Full Name    inaD-like protein
 NCBI Official Synonym Full Names    PATJ, crumbs cell polarity complex component
 NCBI Official Symbol    PATJ [Similar Products]
 NCBI Official Synonym Symbols   
Cipp; INADL; hINADL; InaD-like
[Similar Products]
 NCBI Protein Information    inaD-like protein
 UniProt Protein Name    InaD-like protein
 UniProt Synonym Protein Names   
Pals1-associated tight junction protein; Protein associated to tight junctions
 UniProt Gene Name    INADL [Similar Products]
 UniProt Synonym Gene Names    ; Inadl protein; hINADL [Similar Products]
 UniProt Entry Name    INADL_HUMAN
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 NCBI Summary for INADL    This gene encodes a protein with multiple PDZ domains. PDZ domains mediate protein-protein interactions, and proteins with multiple PDZ domains often organize multimeric complexes at the plasma membrane. This protein localizes to tight junctions and to the apical membrane of epithelial cells. A similar protein in Drosophila is a scaffolding protein which tethers several members of a multimeric signaling complex in photoreceptors. [provided by RefSeq, Jul 2008]
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 UniProt Comments for INADL    INADL: Scaffolding protein that may bring different proteins into adjacent positions at the cell membrane. May regulate protein targeting, cell polarity and integrity of tight junctions. May regulate the surface expression and/or function of ASIC3 in sensory neurons. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1p31.3

Cellular Component: apical plasma membrane; perinuclear region of cytoplasm; plasma membrane; protein complex; tight junction

Molecular Function: protein binding
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 Research Articles on INADL    1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-INADL antibodyPathways associated with anti-INADL antibody
 Reference Product  PubMed Publications
 INADL antibody  >33 publications with INADL and INADL
 CRB3 antibody  >21 publications with INADL and CRB3
 MPP5 antibody  >16 publications with INADL and MPP5
 CRB1 antibody  >11 publications with INADL and CRB1
 AMOT antibody  >7 publications with INADL and AMOT
 CRB2 antibody  >3 publications with INADL and CRB2
 TJP3 antibody  >3 publications with INADL and TJP3
 NPHP4 antibody  >1 publications with INADL and NPHP4
 CLDN1 antibody  >1 publications with INADL and CLDN1
 PARD6A antibody  >1 publications with INADL and PARD6A
 Products by Pathway  Pathway Diagram
 Cell Junction Organization Pathway antibodies  Cell Junction Organization Pathway Diagram
 Cell-Cell Communication Pathway antibodies  Cell-Cell Communication Pathway Diagram
 Cell-cell Junction Organization Pathway antibodies  Cell-cell Junction Organization Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
 Tight Junction Pathway antibodies  Tight Junction Pathway Diagram
 Tight Junction Interactions Pathway antibodies  Tight Junction Interactions Pathway Diagram
Diseases associated with anti-INADL antibodyOrgans/Tissues associated with anti-INADL antibody
 Disease Name  Pubmed Publications
 Eye Diseases Antibodies  >2 publications with INADL and Eye Diseases
 Cell Transformation, Neoplastic Antibodies  >2 publications with INADL and Cell Transformation, Neoplastic
 Cardiovascular Diseases Antibodies  >1 publications with INADL and Cardiovascular Diseases
 Vascular Diseases Antibodies  >1 publications with INADL and Vascular Diseases
 Fibrosis Antibodies  >1 publications with INADL and Fibrosis
 Congenital Abnormalities Antibodies  >1 publications with INADL and Congenital Abnormalities
 Disease Models, Animal Antibodies  >1 publications with INADL and Disease Models, Animal
 Neural Tube Defects Antibodies  >1 publications with INADL and Neural Tube Defects
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >31 publications with INADL and Eye
 Kidney Antibodies  >14 publications with INADL and Kidney
 Liver Antibodies  >4 publications with INADL and Liver
 Embryonic Tissue Antibodies  >3 publications with INADL and Embryonic Tissue
 Blood Antibodies  >3 publications with INADL and Blood
 Testis Antibodies  >2 publications with INADL and Testis
 Lung Antibodies  >2 publications with INADL and Lung
 Intestine Antibodies  >2 publications with INADL and Intestine
 Vascular Antibodies  >2 publications with INADL and Vascular
 Brain Antibodies  >2 publications with INADL and Brain
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