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anti-INCENP antibody :: Rabbit anti-Human INCENP Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS610766 anti-INCENP antibody
Unit / Price
0.1 mL  /  $535 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

INCENP, Polyclonal Antibody

 Also Known As   

INCENP (Incenp, Inner Centromere Protein)

 Product Synonym Names    Anti -INCENP (Incenp, Inner Centromere Protein)
 Product Gene Name   

anti-INCENP antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 11; NC_000011.9 (61891445..61920635). Location: 11q12.3
 OMIM    604411
 3D Structure    ModBase 3D Structure for Q9NQS7
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    Detects endogenous levels of total INCENP protein.
 Purity/Purification    Purified by peptide affinity chromatography.
 Form/Format    Supplied as a liquid in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100ug/ml BSA and 50% glycerol.
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 Immunogen    Synthetic peptide (KLH-coupled) corresponding to amino acids surrounding Pro240 of human INCENP.
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 Preparation and Storage    For long-term storage, aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-INCENP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-INCENP antibody

   INCENP (inner centromere protein antigens 135kD, 155kD) is a chromosomal passenger protein crucial for multiple events that mediate chromosome separation during mitosis (1). At prophase INCENP is associated with chromatin whereas during prometaphase and metaphase it translocates to the inner centromere (1). Depletion of INCENP results in aberrant chromosome alignment at the metaphase plate, incomplete chromosome separation, and disruption of proper spindle formation and cytokinesis (2). INCENP is part of the chromosomal passenger complex that also contains Aurora B, borealin and survivin (2). Aurora B and INCENP are mutually dependent on each other for proper localization (3), and in Drosophila cells and C.elegans embryos that lack INCENP or survivin, Aurora B cannot organize the kinetochores and the midbody (4,5). Phosphorylation on INCENP by CDK1 on Thr59 and Thr388 leads to the association of INCENP with Plk1, another important regulator of mitotic entry and exit (6). Interaction of INCENP with Plk1 is necessary for recruitment of Plk1 to the kinetochores, and the metaphase to anaphase transition (6). Interactions have also been reported between INCENP and heterochromatin protein 1 (HP1) (7) and -tubulin (8).
 Product Categories/Family for anti-INCENP antibody    Antibodies; Abs to Neuroscience
 Applications Tested/Suitable for anti-INCENP antibody   

Western Blot (WB), Flow Cytometry (FC/FACS), Immunofluorescence (IF)

 Application Notes for anti-INCENP antibody    Suitable for use in Immunofluorescence, Flow Cytometry and Western Blot.
Dilution: Immunofluorescence: 1:400
Flow Cytometry: 1:50
Western Blot: 1:1000
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NCBI/Uniprot data below describe general gene information for INCENP. It may not necessarily be applicable to this product.
 NCBI GI #    102467242
 NCBI GeneID    3619
 NCBI Accession #    NP_064623.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_020238.2 [Other Products]
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 UniProt Primary Accession #    Q9NQS7 [Other Products]
 UniProt Secondary Accession #    Q5Y192; A8MQD2 [Other Products]
 UniProt Related Accession #    Q9NQS7 [Other Products]
 Molecular Weight    105,429 Da [Similar Products]
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 NCBI Official Full Name    inner centromere protein isoform 2
 NCBI Official Synonym Full Names    inner centromere protein antigens 135/155kDa
 NCBI Official Symbol    INCENP [Similar Products]
 NCBI Official Synonym Symbols   
FLJ31633; MGC111393
[Similar Products]
 NCBI Protein Information    inner centromere protein; OTTHUMP00000236001; OTTHUMP00000236061; chromosomal passenger protein; inner centromere protein INCENP; binds and activates aurora-B and -C in vivo and in vitro
 UniProt Protein Name    Inner centromere protein
 Protein Family    Inner centromere protein
 UniProt Gene Name    INCENP [Similar Products]
 UniProt Entry Name    INCE_HUMAN
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 NCBI Summary for INCENP    In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A; MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143); MCAK (MIM 604538); KID (MIM 603213); cytoplasmic dynein (e.g., MIM 600112); CliPs (e.g., MIM 179838); and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis (Cutts et al., 1999 [PubMed 10369859]).[supplied by OMIM]
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 UniProt Comments for INCENP    INCENP: Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1. Homodimer or heterodimer. Interacts with H2AFZ. Interacts with CBX3. Interacts with tubulin beta chain. Interacts with AURKB and AURKC. Component of the chromosomal passenger complex (CPC) composed of at least BIRC5/survivin, CDCA8/borealin, INCENP, AURKB and AURKC. Interacts with EVI5. Interacts with CDCA8 and BIRC5; interaction is direct. Interacts with CBX5; POGZ and INCENP compete for interaction with CBX5. Interacts with POGZ. Interacts with JTB. Belongs to the INCENP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; EC 2.7.11.1

Chromosomal Location of Human Ortholog: 11q12.3

Cellular Component: kinetochore; centric heterochromatin; lateral element; microtubule; central element; protein complex; spindle; midbody; cytosol; chromosome, pericentric region; chromocenter

Molecular Function: protein binding

Biological Process: mitosis; cytokinesis; mitotic cell cycle; chromosome segregation
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 Research Articles on INCENP    1. Results indicate that INCENP-Aurora B localized at centromeres/inner kinetochores is sufficient to mediate SAC activity upon spindle disruption.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-INCENP antibodyPathways associated with anti-INCENP antibody
 Reference Product  PubMed Publications
 BIRC5 antibody  >42 publications with INCENP and BIRC5
 CDCA8 antibody  >18 publications with INCENP and CDCA8
 AURKB antibody  >2 publications with INCENP and AURKB
 Products by Pathway  Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Aurora C Signaling Pathway antibodies  Aurora C Signaling Pathway Diagram
 Cell Cycle, Mitotic Pathway antibodies  Cell Cycle, Mitotic Pathway Diagram
 DNA Replication Pathway antibodies  DNA Replication Pathway Diagram
 M Phase Pathway antibodies  M Phase Pathway Diagram
 Mitotic M-M/G1 Phases Pathway antibodies  Mitotic M-M/G1 Phases Pathway Diagram
 Mitotic Prometaphase Pathway antibodies  Mitotic Prometaphase Pathway Diagram
 PLK1 Signaling Events Pathway antibodies  PLK1 Signaling Events Pathway Diagram
 Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway antibodies  Regulation Of Wnt-mediated Beta Catenin Signaling And Target Gene Transcription Pathway Diagram
Diseases associated with anti-INCENP antibodyOrgans/Tissues associated with anti-INCENP antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >16 publications with INCENP and Neoplasms
 Death Antibodies  >9 publications with INCENP and Death
 Carcinoma Antibodies  >4 publications with INCENP and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >3 publications with INCENP and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >2 publications with INCENP and Liver Diseases
 Liver Neoplasms Antibodies  >2 publications with INCENP and Liver Neoplasms
 Breast Neoplasms Antibodies  >2 publications with INCENP and Breast Neoplasms
 Colonic Neoplasms Antibodies  >2 publications with INCENP and Colonic Neoplasms
 Carcinoma, Hepatocellular Antibodies  >1 publications with INCENP and Carcinoma, Hepatocellular
 Esophageal Neoplasms Antibodies  >1 publications with INCENP and Esophageal Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2 publications with INCENP and Blood
 Testis Antibodies  >2 publications with INCENP and Testis
 Eye Antibodies  >2 publications with INCENP and Eye
 Liver Antibodies  >2 publications with INCENP and Liver
 Embryonic Tissue Antibodies  >2 publications with INCENP and Embryonic Tissue
 Intestine Antibodies  >1 publications with INCENP and Intestine
 Kidney Antibodies  >1 publications with INCENP and Kidney
 Uncharacterized Tissue Antibodies  >1 publications with INCENP and Uncharacterized Tissue
 Bone Marrow Antibodies  >1 publications with INCENP and Bone Marrow
 Lymph Node Antibodies  >1 publications with INCENP and Lymph Node
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