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anti-ING3 antibody :: Goat anti-Human ING3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240555
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ING3, Polyclonal Antibody

 Also Known As   

Goat Polyclonal to Human ING3

 Product Synonym Names    Anti-ING3 Antibody (aa294-304) IHC-plus; ING3; p47ING3; Inhibitor of growth protein 3; MEAF4; Eaf4; p47; Human ING3
 Product Gene Name   

anti-ING3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 607493
 3D Structure    ModBase 3D Structure for Q9NXR8
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Human
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 Specificity    aa 294-304 of Human ING3 protein (Inhibitor of growth family, member 3). This sequence only shows homology to isoform 1 for ING3.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human ING3.
 Immunogen Type    Synthetic peptide
 Immunogen    ING3 antibody was raised against synthetic peptide from human ING3.
 Antigen Modification    aa294-304
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 Preparation and Storage    +4 degree C or -20 degree C, Avoid repeated freezing and thawing.
 Other Notes    Small volumes of anti-ING3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ING3 antibody   

Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-ING3 antibody    ELISA (1:10000 - 1:40000), IF, IHC-P (2.5 ug/ml), WB (1:200 - 1:2000)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antib...
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 Immunohistochemistry (IHC) of anti-ING3 antibody    Anti-ING3 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-ING3 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-ING3 antibody    Anti-ING3 Antibody - Western Blot. Western blot of purified anti-ING3 antibody shows detection of a band at ~55 kD corresponding to ING3 in RKO cells transfected with ING3 (lane 2). Control RKO cells do not show detection of this specific band (lane 1). The identity of the non-specific bands at 33 kD and 20 kD has not been determined. Each lane contains approximately 10 ug of RKO whole cell lysate (ATCC# CRL-2577 - human colon cancer) separated on a 4-20% Tris-Glycine gel by SDS-PAGE and transferred to nitrocellulose. After blocking with 5% NF dry milk, the membrane was probed with the primary antibody diluted to 1:1000. Incubation was at 4C overnight followed by washes and reaction with a 1:20000 dilution of IRDye800 conjugated Rb-a-Goat IgG [H&L] MXHu (for 45 min at room temperature. IRDye800 fluorescence image was captured using the Odyssey Infrared Imaging System developed by LI-COR. IRDye is a trademark of LI-COR, Inc. Other detection systems will yield similar results.
anti-ING3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ING3. It may not necessarily be applicable to this product.
 NCBI GI #    38201655
 NCBI GeneID    54556
 NCBI Accession #    NP_061944.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_019071.2 [Other Products]
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 UniProt Primary Accession #    Q9NXR8 [Other Products]
 UniProt Secondary Accession #    O60394; Q567P3; Q6GMT3; Q7Z762; Q969G0; Q96DT4; Q9HC99; Q9P081; A8K790 [Other Products]
 UniProt Related Accession #    Q9NXR8 [Other Products]
 Molecular Weight    11,449 Da
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 NCBI Official Full Name    inhibitor of growth protein 3 isoform 1
 NCBI Official Synonym Full Names    inhibitor of growth family, member 3
 NCBI Official Symbol    ING3 [Similar Products]
 NCBI Official Synonym Symbols   
Eaf4; ING2; MEAF4; p47ING3
[Similar Products]
 NCBI Protein Information    inhibitor of growth protein 3
 UniProt Protein Name    Inhibitor of growth protein 3
 UniProt Synonym Protein Names   
p47ING3
 Protein Family    Inhibitor of growth protein
 UniProt Gene Name    ING3 [Similar Products]
 UniProt Entry Name    ING3_HUMAN
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 NCBI Summary for ING3    The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ING3    ING3: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Defects in ING3 may be a cause of head and neck squamous cell carcinomas (HNSCC); also known as squamous cell carcinoma of the head and neck. Belongs to the ING family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: nucleoplasm; NuA4 histone acetyltransferase complex; cytoplasm; nucleolus; nucleus

Molecular Function: histone acetyltransferase activity; zinc ion binding; methylated histone residue binding

Biological Process: establishment and/or maintenance of chromatin architecture; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of apoptosis; regulation of growth
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 Research Articles on ING3    1. that ING3 may be an important marker for human hepatocellular carcinoma progression and prognosis, as well as a potential therapeutic target.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ING3 antibodyDiseases associated with anti-ING3 antibody
 Products by Pathway  Pathway Diagram
 Chromatin Modifying Enzymes Pathway antibodies  Chromatin Modifying Enzymes Pathway Diagram
 Chromatin Organization Pathway antibodies  Chromatin Organization Pathway Diagram
 HATs Acetylate Histones Pathway antibodies  HATs Acetylate Histones Pathway Diagram
 Disease Name  Pubmed Publications
 Carcinoma, Hepatocellular Antibodies  >5 publications with ING3 and Carcinoma, Hepatocellular
 Adenocarcinoma Antibodies  >3 publications with ING3 and Adenocarcinoma
 Chromosome Aberrations Antibodies  >2 publications with ING3 and Chromosome Aberrations
 Liver Neoplasms Antibodies  >2 publications with ING3 and Liver Neoplasms
 Liver Diseases Antibodies  >2 publications with ING3 and Liver Diseases
 Neurobehavioral Manifestations Antibodies  >1 publications with ING3 and Neurobehavioral Manifestations
 Hypertrophy Antibodies  >1 publications with ING3 and Hypertrophy
 Neoplasm Metastasis Antibodies  >1 publications with ING3 and Neoplasm Metastasis
 Neoplasms, Experimental Antibodies  >1 publications with ING3 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >1 publications with ING3 and Nervous System Diseases
Organs/Tissues associated with anti-ING3 antibody
 Organ/Tissue Name  Pubmed Publications
 Lymph Node Antibodies  >3 publications with ING3 and Lymph Node
 Muscle Antibodies  >3 publications with ING3 and Muscle
 Liver Antibodies  >3 publications with ING3 and Liver
 Blood Antibodies  >2 publications with ING3 and Blood
 Bone Antibodies  >1 publications with ING3 and Bone
 Mouth Antibodies  >1 publications with ING3 and Mouth
 Spleen Antibodies  >1 publications with ING3 and Spleen
 Prostate Antibodies  >1 publications with ING3 and Prostate
 Testis Antibodies  >1 publications with ING3 and Testis
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