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anti-INO80 antibody :: Goat INO80 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS422086 anti-INO80 antibody
Unit / Price
0.1 mg  /  $225 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

INO80, Polyclonal Antibody

 Also Known As   

Goat anti-INO80 Antibody

 Product Synonym Names    INO80; INO80 homolog (S. cerevisiae); INO80A; INOC1; hINO80; INO80 complex homolog 1; INO80 complex subunit A; homolog of yeast INO80; INO80 antibody; INO80 homolog (S. cerevisiae) antibody; INO80A antibody; INOC1 antibody; hINO80 antibody; INO80 complex homolog 1 antibody; INO80 complex subunit A antibody; homolog of yeast INO80 antibody; INO80
 Product Gene Name   

anti-INO80 antibody

[Similar Products]
 Antibody/Peptide Pairs    INO80 peptide (MBS425092) is used for blocking the activity of INO80 antibody (MBS422086)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    TQEDYDSNHF KAQ
 OMIM    610169
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Expected from sequence similarity: Human, Rat Dog, Cow
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence C-TQEDYDSNHFKAQ, from the internal region of the protein sequence according to NP_060023.1.
 Epitope    Internal region
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-INO80 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-INO80 antibody   

Peptide ELISA (EIA)

 Application Notes for anti-INO80 antibody    Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Preliminary experiments in Human Brain (Cerebellum) and Human Testis lysates and in lysates of cell lines HeLa and K562 gave no specific signal but low background (at antibody concentration up to 1ug/ml).
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NCBI/Uniprot data below describe general gene information for INO80. It may not necessarily be applicable to this product.
 NCBI GI #    38708321
 NCBI GeneID    54617
 NCBI Accession #    NP_060023.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_017553.2 [Other Products]
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 UniProt Secondary Accession #    Q9NTG6; A6H8X4 [Other Products]
 UniProt Related Accession #    Q9ULG1 [Other Products]
 Molecular Weight    176,753 Da
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 NCBI Official Full Name    DNA helicase INO80
 NCBI Official Synonym Full Names    INO80 complex subunit
 NCBI Official Symbol    INO80 [Similar Products]
 NCBI Official Synonym Symbols   
INOC1; INO80A; hINO80
[Similar Products]
 NCBI Protein Information    DNA helicase INO80
 UniProt Protein Name    DNA helicase INO80
 UniProt Synonym Protein Names   
INO80 complex subunit A; Putative DNA helicase INO80 complex homolog 1
 Protein Family    INO80 complex
 UniProt Gene Name    INO80 [Similar Products]
 UniProt Synonym Gene Names    INO80A; INOC1; KIAA1259; hINO80 [Similar Products]
 UniProt Entry Name    INO80_HUMAN
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 NCBI Summary for INO80    This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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 UniProt Comments for INO80    INOC1: DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle. Belongs to the SNF2/RAD54 helicase family.

Protein type: EC 3.6.4.12; Helicase; DNA-binding

Chromosomal Location of Human Ortholog: 15q15.1

Cellular Component: microtubule; nucleus

Molecular Function: actin binding; alpha-tubulin binding; ATP binding; ATPase activity; DNA binding; DNA helicase activity; protein binding

Biological Process: cell division; chromatin remodeling; DNA duplex unwinding; double-strand break repair; double-strand break repair via homologous recombination; mitotic sister chromatid segregation; positive regulation of cell growth; positive regulation of transcription from RNA polymerase II promoter; spindle assembly; transcription, DNA-dependent
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 Research Articles on INO80    1. INO80 is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-INO80 antibodyPathways associated with anti-INO80 antibody
 Reference Product  PubMed Publications
 YY1 antibody  >10 publications with INO80 and YY1
 RUVBL2 antibody  >7 publications with INO80 and RUVBL2
 RUVBL1 antibody  >7 publications with INO80 and RUVBL1
 ACTR8 antibody  >6 publications with INO80 and ACTR8
 NFRKB antibody  >4 publications with INO80 and NFRKB
 INO80C antibody  >2 publications with INO80 and INO80C
 MCRS1 antibody  >1 publications with INO80 and MCRS1
 ACTL6A antibody  >1 publications with INO80 and ACTL6A
 Products by Pathway  Pathway Diagram
 DNA Damage Recognition In GG-NER Pathway antibodies  DNA Damage Recognition In GG-NER Pathway Diagram
 DNA Repair Pathway antibodies  DNA Repair Pathway Diagram
 Global Genome Nucleotide Excision Repair (GG-NER) Pathway antibodies  Global Genome Nucleotide Excision Repair (GG-NER) Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
Diseases associated with anti-INO80 antibodyOrgans/Tissues associated with anti-INO80 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >2 publications with INO80 and Kidney Diseases
 Kidney Failure, Chronic Antibodies  >1 publications with INO80 and Kidney Failure, Chronic
 Vascular Diseases Antibodies  >1 publications with INO80 and Vascular Diseases
 Hypertension Antibodies  >1 publications with INO80 and Hypertension
 Nervous System Diseases Antibodies  >1 publications with INO80 and Nervous System Diseases
 Neoplasms, Experimental Antibodies  >1 publications with INO80 and Neoplasms, Experimental
 Carcinoma, Hepatocellular Antibodies  >1 publications with INO80 and Carcinoma, Hepatocellular
 Weight Loss Antibodies  >1 publications with INO80 and Weight Loss
 Necrosis Antibodies  >1 publications with INO80 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >3 publications with INO80 and Kidney
 Brain Antibodies  >3 publications with INO80 and Brain
 Embryonic Tissue Antibodies  >2 publications with INO80 and Embryonic Tissue
 Lung Antibodies  >2 publications with INO80 and Lung
 Blood Antibodies  >1 publications with INO80 and Blood
 Thyroid Antibodies  >1 publications with INO80 and Thyroid
 Vascular Antibodies  >1 publications with INO80 and Vascular
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