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| Product Name
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INO80, Polyclonal Antibody
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| Also Known As
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Goat anti-INO80 Antibody
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| Product Synonym Names
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INO80; INO80 homolog (S. cerevisiae); INO80A; INOC1; hINO80; INO80 complex homolog 1; INO80 complex subunit A; homolog of yeast INO80; INO80 antibody; INO80 homolog (S. cerevisiae) antibody; INO80A antibody; INOC1 antibody; hINO80 antibody; INO80 complex homolog 1 antibody; INO80 complex subunit A antibody; homolog of yeast INO80 antibody; INO80
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| Product Gene Name
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[Similar Products]
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| Antibody/Peptide Pairs
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INO80 peptide (MBS425092) is used for blocking the activity of INO80 antibody (MBS422086)
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| Research Use Only
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For Research Use Only. Not for use in diagnostic procedures.
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 TOP
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| Immunogen Sequence
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TQEDYDSNHF KAQ
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| OMIM
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610169
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| Clonality
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Polyclonal
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| Host
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Goat
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| Species Reactivity
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Expected from sequence similarity: Human, Rat Dog, Cow
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| Purity/Purification
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Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
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| Form/Format
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Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
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| Concentration
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100ug specific antibody in 200ul (lot specific)
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| Immunogen
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Peptide with sequence C-TQEDYDSNHFKAQ, from the internal region of the protein sequence according to NP_060023.1.
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| Epitope
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Internal region
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| Preparation and Storage
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Aliquot and store at -20 degree C. Minimize freezing and thawing.
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| ISO Certification
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Manufactured in an ISO 9001:2015 Certified Laboratory.
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| Other Notes
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Small volumes of anti-INO80 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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TOP
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| Applications Tested/Suitable for anti-INO80 antibody
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Peptide ELISA (EIA)
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| Application Notes for anti-INO80 antibody
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Peptide ELISA: Antibody detection limit dilution 1: 4000.
Western Blot: Preliminary experiments in Human Brain (Cerebellum) and Human Testis lysates and in lysates of cell lines HeLa and K562 gave no specific signal but low background (at antibody concentration up to 1ug/ml).
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TOP
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| NCBI/Uniprot data below describe general gene information for INO80. It may not necessarily be applicable to this product. |
| NCBI GI #
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38708321
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| NCBI GeneID
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54617
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| NCBI Accession #
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NP_060023.1
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[Other Products]
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| NCBI GenBank Nucleotide #
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NM_017553.2
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[Other Products]
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| UniProt Secondary Accession #
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Q9NTG6; A6H8X4
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[Other Products]
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| UniProt Related Accession #
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Q9ULG1
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[Other Products]
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| Molecular Weight
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176,753 Da
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TOP
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| NCBI Official Full Name
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DNA helicase INO80
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| NCBI Official Synonym Full Names
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INO80 complex subunit
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| NCBI Official Symbol
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INO80
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[Similar Products]
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| NCBI Official Synonym Symbols
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INOC1; INO80A; hINO80
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[Similar Products]
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| NCBI Protein Information
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DNA helicase INO80
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| UniProt Protein Name
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DNA helicase INO80
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| UniProt Synonym Protein Names
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INO80 complex subunit A; Putative DNA helicase INO80 complex homolog 1
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| Protein Family
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INO80 complex
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| UniProt Gene Name
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INO80
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[Similar Products]
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| UniProt Synonym Gene Names
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INO80A; INOC1; KIAA1259; hINO80
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[Similar Products]
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| UniProt Entry Name
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INO80_HUMAN
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| NCBI Summary for INO80
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This gene encodes a subunit of the chromatin remodeling complex, which is classified into subfamilies depending on sequence features apart from the conserved ATPase domain. This protein is the catalytic ATPase subunit of the INO80 chromatin remodeling complex, which is characterized by a DNA-binding domain. This protein is proposed to bind DNA and be recruited by the YY1 transcription factor to activate certain genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
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| UniProt Comments for INO80
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INOC1: DNA helicase and probable main scaffold component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair; according to PubMed:20687897 the contribution to DNA double-strand break repair appears to be largely indirect through transcriptional regulation. Recruited by YY1 to YY1-activated genes, where it acts as an essential coactivator. Binds DNA. In vitro, has double stranded DNA-dependent ATPase activity. Involved in UV-damage excision repair, DNA replication and chromosome segregation during normal cell division cycle. Belongs to the SNF2/RAD54 helicase family.
Protein type: EC 3.6.4.12; Helicase; DNA-binding
Chromosomal Location of Human Ortholog: 15q15.1
Cellular Component: microtubule; nucleus
Molecular Function: actin binding; alpha-tubulin binding; ATP binding; ATPase activity; DNA binding; DNA helicase activity; protein binding
Biological Process: cell division; chromatin remodeling; DNA duplex unwinding; double-strand break repair; double-strand break repair via homologous recombination; mitotic sister chromatid segregation; positive regulation of cell growth; positive regulation of transcription from RNA polymerase II promoter; spindle assembly; transcription, DNA-dependent
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TOP
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| Research Articles on INO80
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1. INO80 is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells
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| Precautions
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All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
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| Disclaimer
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While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.
It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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| Products associated with anti-INO80 antibody | Pathways associated with anti-INO80 antibody |
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| Diseases associated with anti-INO80 antibody | Organs/Tissues associated with anti-INO80 antibody |
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TOP
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Antibody 
