Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow INPP5E rightarrow Polyclonal INPP5E  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • Connective tissue growth factor (Ctgf) ELISA Kit
 • anti-Guinea Pig IgA Antibody
 • Epidermal Growth Factor (EGF) ELISA Kit
 • TAR DNA (TARDBP) Antibody
 • A Disintegrin and Metalloproteinase With Thrombospondin 1 (A... ELISA Kit
 • ACE siRNA
 • Toll-like receptor 9 (TLR-9) ELISA Kit
 • Interleukin 6 (IL6) Recombinant Protein
 • Glucose Oxidase (LOC406081) Protein
 • Glutamate-1-semialdehyde 2,1-aminomutase, chloroplastic (GSA... Recombinant Protein
 • Pesticidal crystal protein cry2Ab Recombinant Protein
 • MAP2 Antibody
 • asparagine synthetase (ASNS) Antibody
 • FSTL1 ELISA Kit
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-INPP5E antibody :: Rabbit INPP5E Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS821010 anti-INPP5E antibody
Unit / Price
0.03 mL  /  $155 +1 FREE 8GB USB
0.1 mL  /  $220 +1 FREE 8GB USB
0.2 mL  /  $295 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

INPP5E, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-INPP5E Antibody

 Product Synonym Names    72 kDa inositol polyphosphate 5-phosphatase; Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol polyphosphate 5-phosphatase type IV
 Product Gene Name   

anti-INPP5E antibody

[Similar Products]
 Antibody/Peptide Pairs    INPP5E peptide (MBS824397) is used for blocking the activity of INPP5E antibody (MBS821010)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    phenotype 613037
 3D Structure    ModBase 3D Structure for Q9NRR6
Section Bar
 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Specificity    Recognizes endogenous levels of INPP5E protein.
 Purity/Purification    The antibody was purified by immunogen affinity chromatography.
 Form/Format    Liquid in 0.42% Potassium phosphate, 0.87% Sodium chloride, pH 7.3, 30% glycerol, and 0.01% sodium azide.
Section Bar
 Immunogen    KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human INPP5E. The exact sequence is proprietary.
Section Bar
 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C for one year. Avoid freeze/thaw cycles.
 Other Notes    Small volumes of anti-INPP5E antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Related Product Information for anti-INPP5E antibody

   Rabbit polyclonal antibody to INPP5E
 Applications Tested/Suitable for anti-INPP5E antibody   

Western Blot (WB)

 Application Notes for anti-INPP5E antibody    WB (1/500 - 1/1000)
Section Bar
 Western Blot (WB) of anti-INPP5E antibody    anti-INPP5E antibody Western Blot (WB) (WB) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for INPP5E. It may not necessarily be applicable to this product.
 NCBI GI #    38327539
 NCBI GeneID    56623
 NCBI Accession #    NP_063945.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_019892.4 [Other Products]
Section Bar
 UniProt Primary Accession #    Q9NRR6 [Other Products]
 UniProt Secondary Accession #    Q15734; Q6PIV5 [Other Products]
 UniProt Related Accession #    Q9NRR6 [Other Products]
 Molecular Weight    66,193 Da
Table BarTOPTable Bar
 NCBI Official Full Name    72 kDa inositol polyphosphate 5-phosphatase
 NCBI Official Synonym Full Names    inositol polyphosphate-5-phosphatase, 72 kDa
 NCBI Official Symbol    INPP5E [Similar Products]
 NCBI Official Synonym Symbols   
CPD4; CORS1; JBTS1; MORMS; PPI5PIV
[Similar Products]
 NCBI Protein Information    72 kDa inositol polyphosphate 5-phosphatase; phosphatidylinositol 4,5-bisphosphate 5-phosphatase; phosphatidylinositol-4,5-bisphosphate 5-phosphatase; phosphatidylinositol (4,5) bisphosphate 5-phosphatase; phosphatidylinositol polyphosphate 5-phosphatase type IV
 UniProt Protein Name    72 kDa inositol polyphosphate 5-phosphatase
 UniProt Synonym Protein Names   
Phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol polyphosphate 5-phosphatase type IV
 Protein Family    72 kDa inositol polyphosphate 5-phosphatase
 UniProt Gene Name    INPP5E [Similar Products]
 UniProt Entry Name    INP5E_HUMAN
Section Bar
 NCBI Summary for INPP5E    The protein encoded by this gene is an inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. Studies of the mouse counterpart suggest that this protein may hydrolyze phosphatidylinositol 3,4,5-trisphosphate and phosphatidylinositol 3,5-bisphosphate on the cytoplasmic Golgi membrane and thereby regulate Golgi-vesicular trafficking. Mutations in this gene cause Joubert syndrome; a clinically and genetically heterogenous group of disorders characterized by midbrain-hindbrain malformation and various associated ciliopathies that include retinal dystrophy, nephronophthisis, liver fibrosis and polydactyly.[provided by RefSeq, Feb 2011]
Section Bar
 UniProt Comments for INPP5E    INPP5E: Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns-P2. Specific for lipid substrates, inactive towards water soluble inositol phosphates. Defects in INPP5E are the cause of Joubert syndrome type 1 (JBTS1). A disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermian hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease. Defects in INPP5E are the cause of mental retardation- truncal obesity-retinal dystrophy-micropenis (MORMS). An autosomal recessive disorder characterized by moderate mental retardation, truncal obesity, congenital non-progressive retinal dystrophy, and micropenis in males. The phenotype is similar to Bardet-Biedl syndrome and Cohen syndrome Distinguishing features are the age of onset, the non-progressive nature of the visual impairment, lack of dysmorphic facies, skin or gingival infection, microcephaly, mottled retina, polydactyly, and testicular anomalies. Belongs to the inositol 1,4,5-trisphosphate 5- phosphatase type IV family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Phosphatase (non-protein); Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.36

Chromosomal Location of Human Ortholog: 9q34.3

Cellular Component: ruffle; cytoskeleton; plasma membrane; axoneme; cytosol

Molecular Function: phosphoinositide 5-phosphatase activity; inositol-polyphosphate 5-phosphatase activity

Biological Process: phospholipid metabolic process; organelle organization and biogenesis; inositol phosphate dephosphorylation; phosphatidylinositol biosynthetic process; phosphoinositide dephosphorylation

Disease: Mental Retardation, Truncal Obesity, Retinal Dystrophy, And Micropenis Syndrome; Joubert Syndrome 1
Table BarTOPTable Bar
 Research Articles on INPP5E    1. Proteomic analysis identified INPP5E, whose mutations also lead to Joubert syndrome as novel prenyl-dependent cargo of PDE6D. Mutant PDE6D shows reduced binding to INPP5E, which fails to localize to primary cilia in patient fibroblasts and tissues.
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Pathways associated with anti-INPP5E antibodyDiseases associated with anti-INPP5E antibody
 Products by Pathway  Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 3-phosphoinositide Degradation Pathway antibodies  3-phosphoinositide Degradation Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Inositol Phosphate Metabolism Pathway antibodies  Inositol Phosphate Metabolism Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 PI Metabolism Pathway antibodies  PI Metabolism Pathway Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram
 Phosphatidylinositol Signaling System Pathway antibodies  Phosphatidylinositol Signaling System Pathway Diagram
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >7 publications with INPP5E and Kidney Diseases
 Joubert syndrome 1 Antibodies  >3 publications with INPP5E and Joubert syndrome 1
 Intellectual Disability Antibodies  >3 publications with INPP5E and Intellectual Disability
 Kidney Neoplasms Antibodies  >2 publications with INPP5E and Kidney Neoplasms
 Obesity Antibodies  >2 publications with INPP5E and Obesity
 MORM syndrome Antibodies  >2 publications with INPP5E and MORM syndrome
 Liver Diseases Antibodies  >1 publications with INPP5E and Liver Diseases
 Ciliary Motility Disorders Antibodies  >1 publications with INPP5E and Ciliary Motility Disorders
Organs/Tissues associated with anti-INPP5E antibody
 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >9 publications with INPP5E and Eye
 Liver Antibodies  >3 publications with INPP5E and Liver
 Brain Antibodies  >3 publications with INPP5E and Brain
 Muscle Antibodies  >2 publications with INPP5E and Muscle
 Nerve Antibodies  >1 publications with INPP5E and Nerve
 Blood Antibodies  >1 publications with INPP5E and Blood
 Prostate Antibodies  >1 publications with INPP5E and Prostate
 Embryonic Tissue Antibodies  >1 publications with INPP5E and Embryonic Tissue
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions