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anti-INS antibody :: INS Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS127210
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

INS, Polyclonal Antibody

★Popular Item★
 Also Known As   

INS Polyclonal Antibody

 Product Synonym Names    ILPR; IRDN; IDDM2; MODY10; Insulin
 Product Gene Name   

anti-INS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    phenotype 613370
 3D Structure    ModBase 3D Structure for P01308
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 Clonality    Polyclonal
 Isotype    IgG
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Source    Rabbit
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human INS
 Calculated Molecular Weight    12kDa
 Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-INS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-INS antibody

   The maintenance of glucose homeostasis is an essential physiological process that is regulated by hormones. An elevation in blood glucose levels during feeding stimulates insulin release from pancreatic beta cells through a glucose sensing pathway (1). Insulin is synthesized as a precursor molecule, proinsulin, which is processed prior to secretion. A- and B-peptides are joined together by a disulfide bond to form insulin, while the central portion of the precursor molecule is cleaved and released as the C-peptide. Insulin stimulates glucose uptake from blood into skeletal muscle and adipose tissue. Insulin deficiency leads to type 1 diabetes mellitus (2).
 Product Categories/Family for anti-INS antibody    Polyclonal
 Applications Tested/Suitable for anti-INS antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-INS antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-INS antibody    Western blot analysis of extracts of mouse pancreas, using INS antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
Detection: ECL Enhanced Kit.
Exposure time: 30s.
anti-INS antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for INS. It may not necessarily be applicable to this product.
 NCBI GI #    124617
 NCBI GeneID    3630
 NCBI Accession #    P01308.1 [Other Products]
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 UniProt Primary Accession #    P01308 [Other Products]
 UniProt Secondary Accession #    Q5EEX2 [Other Products]
 UniProt Related Accession #    P01308 [Other Products]
 Molecular Weight    110
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 NCBI Official Full Name    Insulin
 NCBI Official Synonym Full Names    insulin
 NCBI Official Symbol    INS [Similar Products]
 NCBI Official Synonym Symbols   
IDDM; ILPR; IRDN; IDDM1; IDDM2; MODY10
[Similar Products]
 NCBI Protein Information    insulin; proinsulin; preproinsulin
 UniProt Protein Name    Insulin
 Protein Family    Insulin
 UniProt Gene Name    INS [Similar Products]
 UniProt Entry Name    INS_HUMAN
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 NCBI Summary for INS    After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
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 UniProt Comments for INS    Insulin: Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. Heterodimer of a B chain and an A chain linked by two disulfide bonds. Belongs to the insulin family.

Protein type: Secreted; Secreted, signal peptide; Hormone

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: extracellular space; Golgi lumen; endoplasmic reticulum lumen; extracellular region

Molecular Function: identical protein binding; insulin-like growth factor receptor binding; protein binding; protease binding; hormone activity; insulin receptor binding

Biological Process: positive regulation of nitric oxide biosynthetic process; positive regulation of vasodilation; glucose homeostasis; activation of NF-kappaB transcription factor; positive regulation of glucose import; negative regulation of protein oligomerization; regulation of protein localization; cell-cell signaling; negative regulation of gluconeogenesis; acute-phase response; regulation of transmembrane transporter activity; negative regulation of NAD(P)H oxidase activity; positive regulation of mitosis; activation of protein kinase B; positive regulation of nitric-oxide synthase activity; negative regulation of acute inflammatory response; glucose metabolic process; positive regulation of lipid biosynthetic process; positive regulation of protein amino acid autophosphorylation; positive regulation of cell growth; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of cell differentiation; negative regulation of protein catabolic process; regulation of amino acid metabolic process; negative regulation of glycogen catabolic process; wound healing; positive regulation of glycogen biosynthetic process; positive regulation of cellular protein metabolic process; glucose transport; regulation of protein secretion; negative regulation of lipid catabolic process; regulation of transcription, DNA-dependent; positive regulation of MAPKKK cascade; negative regulation of vasodilation; positive regulation of cell proliferation; negative regulation of proteolysis; negative regulation of protein secretion; MAPKKK cascade; negative regulation of fatty acid metabolic process; alpha-beta T cell activation; endocrine pancreas development; G-protein coupled receptor protein signaling pathway; positive regulation of protein kinase B signaling cascade; cellular protein metabolic process; fatty acid homeostasis; positive regulation of glycolysis; insulin receptor signaling pathway; energy reserve metabolic process; positive regulation of insulin receptor signaling pathway; regulation of insulin secretion; positive regulation of DNA replication; positive regulation of cytokine secretion; positive regulation of cell migration

Disease: Diabetes Mellitus, Insulin-dependent, 2; Diabetes Mellitus, Permanent Neonatal; Hyperproinsulinemia; Maturity-onset Diabetes Of The Young, Type 10
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 Research Articles on INS    1. Adiponectin limits fetal growth mediated by activation of placental PPARalpha and ceramide synthesis, which inhibits placental insulin signaling and amino acid transport, resulting in reduced fetal nutrient availability.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-INS antibodyPathways associated with anti-INS antibody
 Reference Product  PubMed Publications
 IRS1 antibody  >38 publications with INS and IRS1
 FOXO1 antibody  >31 publications with INS and FOXO1
 INSR antibody  >31 publications with INS and INSR
 IRS2 antibody  >29 publications with INS and IRS2
 AKT1 antibody  >18 publications with INS and AKT1
 GRB2 antibody  >11 publications with INS and GRB2
 IDE antibody  >9 publications with INS and IDE
 IGFBP1 antibody  >6 publications with INS and IGFBP1
 AKT2 antibody  >3 publications with INS and AKT2
 PTPN1 antibody  >3 publications with INS and PTPN1
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 ATF-2 Transcription Factor Network Pathway antibodies  ATF-2 Transcription Factor Network Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Amyloids Pathway antibodies  Amyloids Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Cardiac Progenitor Differentiation Pathway antibodies  Cardiac Progenitor Differentiation Pathway Diagram
Diseases associated with anti-INS antibodyOrgans/Tissues associated with anti-INS antibody
 Disease Name  Pubmed Publications
 Metabolic Diseases Antibodies  >1111 publications with INS and Metabolic Diseases
 Diabetes Mellitus Antibodies  >924 publications with INS and Diabetes Mellitus
 Insulin Resistance Antibodies  >338 publications with INS and Insulin Resistance
 Diabetes Mellitus, Type 2 Antibodies  >317 publications with INS and Diabetes Mellitus, Type 2
 Obesity Antibodies  >248 publications with INS and Obesity
 Hyperglycemia Antibodies  >223 publications with INS and Hyperglycemia
 Hyperinsulinism Antibodies  >219 publications with INS and Hyperinsulinism
 Hypertension Antibodies  >129 publications with INS and Hypertension
 Polycystic Ovary Syndrome Antibodies  >60 publications with INS and Polycystic Ovary Syndrome
 Fatty Liver Antibodies  >49 publications with INS and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Pancreas Antibodies  >1568 publications with INS and Pancreas
 Blood Antibodies  >1552 publications with INS and Blood
 Brain Antibodies  >784 publications with INS and Brain
 Muscle Antibodies  >565 publications with INS and Muscle
 Liver Antibodies  >418 publications with INS and Liver
 Heart Antibodies  >309 publications with INS and Heart
 Kidney Antibodies  >280 publications with INS and Kidney
 Vascular Antibodies  >279 publications with INS and Vascular
 Nerve Antibodies  >277 publications with INS and Nerve
 Bone Antibodies  >164 publications with INS and Bone
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