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anti-INVS antibody :: Rabbit anti-Human INVS Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS7044719
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

INVS, Polyclonal Antibody

★Popular Item★
 Also Known As   

INVS Antibody

 Product Synonym Names    Inversin; Inversion of embryo turning homolog; Nephrocystin-2; INVS; INV; NPHP2
 Product Gene Name   

anti-INVS antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    243305
 3D Structure    ModBase 3D Structure for Q9Y283
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    >95%, Protein G purified
 Form/Format    Liquid
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 Species    Human
 Immunogen    Recombinant human Inversin protein
 Conjugate    Non-conjugated
 Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-8719 / sc-12550
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-INVS antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-INVS antibody

   Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).
 Applications Tested/Suitable for anti-INVS antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

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 Western Blot (WB) of anti-INVS antibody    Western blot
All lanes: INVS antibody IgG at 14ug/ml+ K562 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 118,100,11 kDa
Observed band size: 118 kDa

anti-INVS antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-INVS antibody    Immunohistochemistry of paraffin-embedded human liver cancer using MBS7044719 at dilution 1:100
anti-INVS antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-INVS antibody    Immunofluorescent analysis of HepG-2 cells using MBS7044719 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-INVS antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for INVS. It may not necessarily be applicable to this product.
 NCBI GI #    34304381
 NCBI GeneID    27130
 NCBI Accession #    NP_055240.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_014425.4 [Other Products]
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 UniProt Primary Accession #    Q9Y283 [Other Products]
 UniProt Secondary Accession #    Q2NKL0; Q5W0T6; Q8IVX8; Q9BRB9; Q9Y488; Q9Y498; A2A2Y2 [Other Products]
 UniProt Related Accession #    Q9Y283 [Other Products]
 Molecular Weight    10,748 Da
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 NCBI Official Full Name    inversin isoform a
 NCBI Official Synonym Full Names    inversin
 NCBI Official Symbol    INVS [Similar Products]
 NCBI Official Synonym Symbols   
INV; NPH2; NPHP2
[Similar Products]
 NCBI Protein Information    inversin
 UniProt Protein Name    Inversin
 UniProt Synonym Protein Names   
Inversion of embryo turning homolog; Nephrocystin-2
 Protein Family    Inversin
 UniProt Gene Name    INVS [Similar Products]
 UniProt Synonym Gene Names    INV; NPHP2 [Similar Products]
 UniProt Entry Name    INVS_HUMAN
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 NCBI Summary for INVS    This gene encodes a protein containing multiple ankyrin domains and two IQ calmodulin-binding domains. The encoded protein may function in renal tubular development and function, and in left-right axis determination. This protein interacts with nephrocystin and infers a connection between primary cilia function and left-right axis determination. A similar protein in mice interacts with calmodulin. Mutations in this gene have been associated with nephronophthisis type 2. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2012]
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 UniProt Comments for INVS    INVS: Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Involved in the organization of apical junctions in kidney cells together with NPHP1, NPHP4 and RPGRIP1L/NPHP8. Does not seem to be strictly required for ciliogenesis. Defects in INVS are the cause of nephronophthisis type 2 (NPHP2); also known as infantile nephronophthisis. NPHP2 is an autosomal recessive disorder resulting in end-stage renal disease. It is characterized by early onset and rapid progression. Phenotypic manifestations include enlarged kidneys, chronic tubulo-interstitial nephritis, anemia, hyperkalemic metabolic acidosis. Some patients also display situs inversus. Pathologically, it differs from later-onset nephronophthisis by the absence of medullary cysts and thickened tubular basement membranes and by the presence of cortical microcysts. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 9q31

Molecular Function: protein binding

Disease: Nephronophthisis 2
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 Research Articles on INVS    1. Truncating mutations in NPHP2 gene is associated with nephronophthisis-related ciliopathy.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-INVS antibodyPathways associated with anti-INVS antibody
 Reference Product  PubMed Publications
 NPHP1 antibody  >16 publications with INVS and NPHP1
 NPHP3 antibody  >12 publications with INVS and NPHP3
 NPHP4 antibody  >10 publications with INVS and NPHP4
 PKHD1 antibody  >6 publications with INVS and PKHD1
 DVL1 antibody  >2 publications with INVS and DVL1
 CEP290 antibody  >2 publications with INVS and CEP290
 B9D2 antibody  >1 publications with INVS and B9D2
 ANAPC2 antibody  >1 publications with INVS and ANAPC2
 Products by Pathway  Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
 Wnt Signaling Pathway antibodies  Wnt Signaling Pathway Diagram
Diseases associated with anti-INVS antibodyOrgans/Tissues associated with anti-INVS antibody
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >63 publications with INVS and Immune System Diseases
 Kidney Diseases Antibodies  >49 publications with INVS and Kidney Diseases
 Cardiovascular Diseases Antibodies  >44 publications with INVS and Cardiovascular Diseases
 Liver Diseases Antibodies  >36 publications with INVS and Liver Diseases
 Poisoning Antibodies  >28 publications with INVS and Poisoning
 Vascular Diseases Antibodies  >24 publications with INVS and Vascular Diseases
 Hypertension Antibodies  >17 publications with INVS and Hypertension
 Heart Diseases Antibodies  >16 publications with INVS and Heart Diseases
 Asthma Antibodies  >14 publications with INVS and Asthma
 Inflammation Antibodies  >11 publications with INVS and Inflammation
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >79 publications with INVS and Blood
 Kidney Antibodies  >62 publications with INVS and Kidney
 Liver Antibodies  >16 publications with INVS and Liver
 Brain Antibodies  >16 publications with INVS and Brain
 Lung Antibodies  >15 publications with INVS and Lung
 Skin Antibodies  >9 publications with INVS and Skin
 Eye Antibodies  >6 publications with INVS and Eye
 Thyroid Antibodies  >5 publications with INVS and Thyroid
 Embryonic Tissue Antibodies  >5 publications with INVS and Embryonic Tissue
 Bone Marrow Antibodies  >3 publications with INVS and Bone Marrow
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