AAK59843.1
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
10,646 Da
NCBI Official Full Name
ICE-protease activating factor
NCBI Official Synonym Full Names
NLR family, CARD domain containing 4
NCBI Official Synonym Symbols
CLAN; IPAF; AIFEC; CLAN1; CLANA; CLANB; CLANC; CLAND; FCAS4; CARD12; CLR2.1 [Similar Products]
NCBI Protein Information
NLR family CARD domain-containing protein 4; CARD, LRR, and NACHT-containing protein; ICE-protease activating factor; NOD-like receptor C4; caspase recruitment domain family, member 12; caspase recruitment domain-containing protein 12; nucleotide-binding oligomerization domain, leucine rich repeat and CARD domain containing 4
UniProt Protein Name
NLR family CARD domain-containing protein 4
UniProt Synonym Protein Names
CARD, LRR, and NACHT-containing protein; Clan protein; Caspase recruitment domain-containing protein 12; Ice protease-activating factor; Ipaf
UniProt Synonym Gene Names
UniProt Entry Name
NLRC4_HUMAN
NCBI Summary for IPAF
This gene encodes a member of the caspase recruitment domain-containing NLR family. Family members play essential roles in innate immune response to a wide range of pathogenic organisms, tissue damage and other cellular stresses. Mutations in this gene result in autoinflammation with infantile enterocolitis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
UniProt Comments for IPAF
NLRC4: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 2p22.3
Cellular Component: spindle microtubule; cytoplasm; intracellular; nucleus; cytosol
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; magnesium ion binding; ubiquitin-protein ligase activity; cysteine protease inhibitor activity; ATP binding
Biological Process: caspase activation; detection of bacterium; positive regulation of apoptosis; regulation of signal transduction; protein ubiquitination; activation of NF-kappaB transcription factor; defense response to bacterium; regulation of neuron apoptosis; innate immune response; interleukin-1 beta secretion; inflammatory response; activation of innate immune response; protein homooligomerization; negative regulation of apoptosis
Disease: Autoinflammation With Infantile Enterocolitis; Familial Cold Autoinflammatory Syndrome 4
Research Articles on IPAF
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Products associated with anti-IPAF antibody
Pathways associated with anti-IPAF antibody
Diseases associated with anti-IPAF antibody
Organs/Tissues associated with anti-IPAF antibody
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