NP_003861.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
Observed: 190 kD Predicted: 190 kDa
NCBI Official Full Name
ras GTPase-activating-like protein IQGAP1
NCBI Official Synonym Full Names
IQ motif containing GTPase activating protein 1
NCBI Protein Information
ras GTPase-activating-like protein IQGAP1
UniProt Protein Name
Ras GTPase-activating-like protein IQGAP1
UniProt Synonym Protein Names
p195
UniProt Synonym Gene Names
NCBI Summary for IQGAP1
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines. [provided by RefSeq, Jul 2008]
UniProt Comments for IQGAP1
Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth (PubMed:15695813). May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest (PubMed:20883816).
Research Articles on IQGAP1
Precautions
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Disclaimer
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Products associated with anti-IQGAP1 antibody
Pathways associated with anti-IQGAP1 antibody
Diseases associated with anti-IQGAP1 antibody
Organs/Tissues associated with anti-IQGAP1 antibody
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