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anti-IRAK3 antibody :: Rabbit IRAK-M Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150500
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IRAK-M (IRAK3), Polyclonal Antibody

★Popular Item★
 Also Known As   

IRAK-M Antibody

 Product Synonym Names    IRAK-M; ASRT5; IRAKM; Interleukin-1 receptor-associated kinase 3; IL-1 receptor-associated kinase M; IRAK-3; interleukin-1 receptor-associated kinase 3
 Product Gene Name   

anti-IRAK3 antibody

[Similar Products]
 Antibody/Peptide Pairs    IRAK-M peptide (MBS152204) is used for blocking the activity of IRAK-M antibody (MBS150500)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 611064
 3D Structure    ModBase 3D Structure for Q9Y616
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    IRAK-M antibody has no cross response to IRAK or IRAK2.
 Purity/Purification    IRAK-M Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
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 Conjugate    Unconjugated
 Immunogen    IRAK-M antibody was raised against a peptide corresponding to amino acids from the carboxy terminus of human IRAK-M.
 Buffer    IRAK-M Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    IRAK-M antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-IRAK3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IRAK3 antibody

   IRAK-M Antibody: Interleukin-1 (IL-1) and lipopolysaccharide (LPS) induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor-associated kinase (IRAK and IRAK2) mediates the activation of NF-betaB by IL-1/Toll receptors, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family was recently identified and designated IRAK-M. IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and the dominant negative mutants of IRAKs inhibit IL-1 or LPS induced NF-betaB activation. Members in IRAK/Pelle family play a central role in IL-1R/TLR mediated inflammatory responses to cytokine IL-1 and LPS.
 Applications Tested/Suitable for anti-IRAK3 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-IRAK3 antibody    IRAK-M antibody can be used for detection of IRAK-M by Western blot at 1 mug/mL. A 68 kDa major band can be detected. IRAK-M antibody can also detect IRAK-M by immunohistochemistry at 2 mug/mL. For immunofluorescence start at 10 mug/mL.
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 Western Blot (WB) of anti-IRAK3 antibody    Western blot analysis of IRAK-M in (M) mouse spleen and (R) rat liver tissue lysates with IRAK-M antibody at 1 μg/mL.
anti-IRAK3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-IRAK3 antibody    Immunohistochemical staining of rat liver tissue using IRAK-M antibody at 2 μg/mL.
anti-IRAK3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-IRAK3 antibody    Immunofluorescence of IRAK-M in Rat Liver tissue with IRAK-M antibody at 10 μg/mL.
anti-IRAK3 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for IRAK3. It may not necessarily be applicable to this product.
 NCBI GI #    5225377
 NCBI GeneID    11213
 NCBI Accession #    AF113136 [Other Products]
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 UniProt Primary Accession #    Q9Y616 [Other Products]
 UniProt Secondary Accession #    B4DQ57 [Other Products]
 UniProt Related Accession #    Q9Y616 [Other Products]
 Molecular Weight    68 kDa
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 NCBI Official Full Name    Homo sapiens IL-1 receptor-associated-kinase-M mRNA, complete cds
 NCBI Official Synonym Full Names    interleukin-1 receptor-associated kinase 3
 NCBI Official Symbol    IRAK3 [Similar Products]
 NCBI Official Synonym Symbols   
ASRT5; IRAKM
[Similar Products]
 NCBI Protein Information    interleukin-1 receptor-associated kinase 3; IRAK3; IL-1 receptor-associated kinase M
 UniProt Protein Name    Interleukin-1 receptor-associated kinase 3
 UniProt Synonym Protein Names   
IL-1 receptor-associated kinase M; IRAK-M
 Protein Family    Interleukin-1 receptor-associated kinase
 UniProt Gene Name    IRAK3 [Similar Products]
 UniProt Synonym Gene Names    IRAK-3; IRAK-M [Similar Products]
 UniProt Entry Name    IRAK3_HUMAN
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 NCBI Summary for IRAK3    This gene encodes a member of the interleukin-1 receptor-associated kinase protein family. Members of this family are essential components of the Toll/IL-R immune signal transduction pathways. This protein is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. Mutations in this gene are associated with a susceptibility to asthma. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
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 UniProt Comments for IRAK3    IRAK3: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Protein kinase, TKL; EC 2.7.11.1; TKL group; IRAK family

Chromosomal Location of Human Ortholog: 12q14.3

Cellular Component: interleukin-1 receptor complex; cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; protein homodimerization activity; protein heterodimerization activity; magnesium ion binding; ATP binding

Biological Process: negative regulation of MAP kinase activity; regulation of protein complex disassembly; negative regulation of interleukin-12 production; protein amino acid autophosphorylation; cytokine and chemokine mediated signaling pathway; response to virus; response to lipopolysaccharide; negative regulation of tumor necrosis factor production; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; MyD88-dependent toll-like receptor signaling pathway; response to exogenous dsRNA; negative regulation of innate immune response; inhibition of NF-kappaB transcription factor; response to peptidoglycan; negative regulation of toll-like receptor signaling pathway; toll-like receptor signaling pathway; negative regulation of interleukin-6 production; negative regulation of cytokine and chemokine mediated signaling pathway; negative regulation of protein catabolic process; negative regulation of protein complex disassembly

Disease: Asthma-related Traits, Susceptibility To, 5
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 Research Articles on IRAK3    1. our study demonstrates that patients carrying IRAK-M+22148 G haplotype are more susceptible to sepsis than patients carrying IRAK-M+22148 A haplotype, suggesting that IRAK-M+22148 G haplotype might be a risk factor for sepsis.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IRAK3 antibodyPathways associated with anti-IRAK3 antibody
 Reference Product  PubMed Publications
 IRAK2 antibody  >113 publications with IRAK3 and IRAK2
 MYD88 antibody  >24 publications with IRAK3 and MYD88
 IRAK1 antibody  >17 publications with IRAK3 and IRAK1
 TRAF6 antibody  >14 publications with IRAK3 and TRAF6
 IRAK4 antibody  >11 publications with IRAK3 and IRAK4
 TOLLIP antibody  >7 publications with IRAK3 and TOLLIP
 TIRAP antibody  >2 publications with IRAK3 and TIRAP
 IL1R1 antibody  >1 publications with IRAK3 and IL1R1
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IL1-mediated Signaling Events Pathway antibodies  IL1-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Interleukin-1 Signaling Pathway antibodies  Interleukin-1 Signaling Pathway Diagram
 MyD88:Mal Cascade Initiated On Plasma Membrane Pathway antibodies  MyD88:Mal Cascade Initiated On Plasma Membrane Pathway Diagram
 Neurotrophin Signaling Pathway antibodies  Neurotrophin Signaling Pathway Diagram
Diseases associated with anti-IRAK3 antibodyOrgans/Tissues associated with anti-IRAK3 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >55 publications with IRAK3 and Inflammation
 Necrosis Antibodies  >34 publications with IRAK3 and Necrosis
 Lung Diseases Antibodies  >18 publications with IRAK3 and Lung Diseases
 Disease Models, Animal Antibodies  >11 publications with IRAK3 and Disease Models, Animal
 Cardiovascular Diseases Antibodies  >8 publications with IRAK3 and Cardiovascular Diseases
 Asthma Antibodies  >7 publications with IRAK3 and Asthma
 Liver Diseases Antibodies  >4 publications with IRAK3 and Liver Diseases
 Heart Diseases Antibodies  >3 publications with IRAK3 and Heart Diseases
 Lung Neoplasms Antibodies  >2 publications with IRAK3 and Lung Neoplasms
 Kidney Diseases Antibodies  >2 publications with IRAK3 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >52 publications with IRAK3 and Blood
 Lung Antibodies  >25 publications with IRAK3 and Lung
 Bone Antibodies  >12 publications with IRAK3 and Bone
 Bone Marrow Antibodies  >10 publications with IRAK3 and Bone Marrow
 Placenta Antibodies  >4 publications with IRAK3 and Placenta
 Brain Antibodies  >4 publications with IRAK3 and Brain
 Heart Antibodies  >4 publications with IRAK3 and Heart
 Kidney Antibodies  >4 publications with IRAK3 and Kidney
 Uterus Antibodies  >2 publications with IRAK3 and Uterus
 Skin Antibodies  >2 publications with IRAK3 and Skin
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