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anti-IRAK1 antibody :: Goat anti-Human IRAK1 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS615736 anti-IRAK1 antibody
Unit / Price
0.1 mg  /  $755 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IRAK1, Polyclonal Antibody

 Also Known As   

IRAK1 (IL-1 Receptor-associated Kinase)

 Product Synonym Names    Anti -IRAK1 (IL-1 Receptor-associated Kinase)
 Product Gene Name   

anti-IRAK1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: X; NC_000023.10 (153275957..153285342, complement). Location: Xq28
 3D Structure    ModBase 3D Structure for Q96C06
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
 Species Reactivity    Human
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 Specificity    Recognizes endogenous human IRAK1 at 80kD. Does not detect recombinant human IRAK2 or IRAK4; crossreactivity with IRAK-M is not known.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a lyophilized powder from PBS with 5% trehalose. Reconstitute with sterile 40-50% glycerol, PBS, 0.02% sodium azide.
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 Immunogen    E. coli-derived rhIRAK1 (aa1-693)
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute by adding sterile 40-50% glycerol, PBS, 0.02% sodium azide. Aliquot and store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-IRAK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-IRAK1 antibody    Antibodies; Abs to Protein Kinases
 Applications Tested/Suitable for anti-IRAK1 antibody   

Western Blot (WB)

 Application Notes for anti-IRAK1 antibody    Suitable for use in Western Blot.
Dilution: Western Blot: 1.0ug/ml
Optimal dilution determined by the researcher.
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NCBI/Uniprot data below describe general gene information for IRAK1. It may not necessarily be applicable to this product.
 NCBI GI #    68800350
 NCBI GeneID    3654
 NCBI Accession #    NP_001020414.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001025243.1 [Other Products]
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 UniProt Primary Accession #    Q96C06 [Other Products]
 UniProt Related Accession #    P51617; Q96C06 [Other Products]
 Molecular Weight    67,988 Da [Similar Products]
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 NCBI Official Full Name    interleukin-1 receptor-associated kinase 1 isoform 3
 NCBI Official Synonym Full Names    interleukin-1 receptor-associated kinase 1
 NCBI Official Symbol    IRAK1 [Similar Products]
 NCBI Official Synonym Symbols   
IRAK; pelle
[Similar Products]
 NCBI Protein Information    interleukin-1 receptor-associated kinase 1; IRAK-1; Pelle homolog; OTTHUMP00000026014; OTTHUMP00000026015; OTTHUMP00000026020; OTTHUMP00000180621
 UniProt Protein Name    Interleukin-1 receptor associated-kinase 1 splice variant c
 Protein Family    Interleukin-1 receptor-associated kinase
 UniProt Gene Name    IRAK1 [Similar Products]
 UniProt Entry Name    Q96C06_HUMAN
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 NCBI Summary for IRAK1    This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for IRAK1    IRAK1: a TKL kinase of the IRAK family. Involved in Toll/IL-1 signaling. One of two putative serine/threonine kinases that become associated with the interleukin-1 receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Extensively phosphorylated after its association with IL1-R-1. Polyubiquitinated; after cell stimulation with IL-1-beta. Polyubiquitination occurs with polyubiquitin chains linked through 'Lys-63'. Partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Three isoforms of the human protein and produced by alternative splicing. Isoform 1 binds rapidly but is then degraded allowing isoform 2 to mediate a slower, more sustained response to the cytokine. Isoform 2 is inactive suggesting that the kinase activity of this enzyme is not required for IL-1 signaling. Once phosphorylated, IRAK1 recruits the adapter protein PELI1. Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2.

Protein type: Protein kinase, TKL; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; TKL group; IRAK family

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: interleukin-1 receptor complex; cytoplasm; plasma membrane; endosome membrane; lipid particle; cytosol; nucleus

Molecular Function: NF-kappaB-inducing kinase activity; protein serine/threonine kinase activity; protein binding; protein homodimerization activity; interleukin-1 receptor binding; protein heterodimerization activity; heat shock protein binding; ubiquitin-protein ligase activity; kinase activity; ATP binding; protein kinase activity

Biological Process: nerve growth factor receptor signaling pathway; activation of MAPK activity; protein amino acid autophosphorylation; positive regulation of transcription, DNA-dependent; positive regulation of smooth muscle cell proliferation; stress-activated MAPK cascade; protein ubiquitination; response to lipopolysaccharide; toll-like receptor 3 signaling pathway; signal transduction; protein amino acid phosphorylation; activation of NF-kappaB transcription factor; toll-like receptor 10 signaling pathway; toll-like receptor 5 signaling pathway; positive regulation of MAP kinase activity; response to peptidoglycan; transmembrane receptor protein serine/threonine kinase signaling pathway; lipopolysaccharide-mediated signaling pathway; JNK cascade; toll-like receptor 4 signaling pathway; aging; positive regulation of I-kappaB kinase/NF-kappaB cascade; MyD88-independent toll-like receptor signaling pathway; activation of NF-kappaB-inducing kinase; protein oligomerization; toll-like receptor 2 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; inhibition of NF-kappaB transcription factor; toll-like receptor signaling pathway; innate immune response; regulation of cytokine and chemokine mediated signaling pathway; toll-like receptor 9 signaling pathway; negative regulation of apoptosis
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 Research Articles on IRAK1    1. LPS-induced activation of IRAK4 and TAK1, K63-linked polyubiquitination of IRAK1 and TRAF6, and disrupted IRAK1-TRAF6 and IRAK1-IKKgamma assembly associated with increased A20 expression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IRAK1 antibodyPathways associated with anti-IRAK1 antibody
 Reference Product  PubMed Publications
 IRAK2 antibody  >191 publications with IRAK1 and IRAK2
 TRAF6 antibody  >76 publications with IRAK1 and TRAF6
 MYD88 antibody  >76 publications with IRAK1 and MYD88
 TLR4 antibody  >67 publications with IRAK1 and TLR4
 IRAK4 antibody  >45 publications with IRAK1 and IRAK4
 TLR2 antibody  >42 publications with IRAK1 and TLR2
 IRAK3 antibody  >14 publications with IRAK1 and IRAK3
 JUN antibody  >12 publications with IRAK1 and JUN
 TOLLIP antibody  >9 publications with IRAK1 and TOLLIP
 PELI1 antibody  >6 publications with IRAK1 and PELI1
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IL-1 Signaling Pathway antibodies  IL-1 Signaling Pathway Diagram
 IL1-mediated Signaling Events Pathway antibodies  IL1-mediated Signaling Events Pathway Diagram
 IRAK1 Recruits IKK Comlex Pathway antibodies  IRAK1 Recruits IKK Comlex Pathway Diagram
 IRAK1 Recruits IKK Comlex Upon TLR7/8 Or 9 Stimulation Pathway antibodies  IRAK1 Recruits IKK Comlex Upon TLR7/8 Or 9 Stimulation Pathway Diagram
Diseases associated with anti-IRAK1 antibodyOrgans/Tissues associated with anti-IRAK1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >52 publications with IRAK1 and Inflammation
 Neoplasms Antibodies  >23 publications with IRAK1 and Neoplasms
 Autoimmune Diseases Antibodies  >18 publications with IRAK1 and Autoimmune Diseases
 Atherosclerosis Antibodies  >10 publications with IRAK1 and Atherosclerosis
 Carcinoma Antibodies  >10 publications with IRAK1 and Carcinoma
 Sepsis Antibodies  >8 publications with IRAK1 and Sepsis
 Arthritis, Rheumatoid Antibodies  >7 publications with IRAK1 and Arthritis, Rheumatoid
 Rheumatic Diseases Antibodies  >7 publications with IRAK1 and Rheumatic Diseases
 Arteriosclerosis Antibodies  >6 publications with IRAK1 and Arteriosclerosis
 Adenocarcinoma Antibodies  >6 publications with IRAK1 and Adenocarcinoma
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >46 publications with IRAK1 and Blood
 Liver Antibodies  >14 publications with IRAK1 and Liver
 Kidney Antibodies  >12 publications with IRAK1 and Kidney
 Vascular Antibodies  >12 publications with IRAK1 and Vascular
 Brain Antibodies  >10 publications with IRAK1 and Brain
 Bone Antibodies  >10 publications with IRAK1 and Bone
 Intestine Antibodies  >8 publications with IRAK1 and Intestine
 Muscle Antibodies  >8 publications with IRAK1 and Muscle
 Lung Antibodies  >8 publications with IRAK1 and Lung
 Heart Antibodies  >7 publications with IRAK1 and Heart
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