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anti-Irak2 antibody :: Rabbit anti-Human, Mouse IRAK2 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150516
Unit / Price
0.1 mg  /  $365 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IRAK2, Polyclonal Antibody

 Also Known As   

IRAK2 Antibody

 Product Synonym Names    IRAK2; IRAK-2; AI649099; 6330415L08Rik; Interleukin-1 receptor-associated kinase-like 2; IRAK-2; interleukin-1 receptor-associated kinase 2
 Product Gene Name   

anti-Irak2 antibody

[Similar Products]
 Antibody/Peptide Pairs    IRAK2 peptide (MBS152293) is used for blocking the activity of IRAK2 antibody (MBS150516)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 3D Structure    ModBase 3D Structure for Q8CFA1
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    Anti-IRAK2 has no cross response to IRAK. Anti-IRAK2 will also recognize human IRAK2.
 Purity/Purification    IRAK2 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    IRAK2 antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of mouse IRAK2a which is common to all four isoforms.
 Buffer    IRAK2 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    IRAK2 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-Irak2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-Irak2 antibody

   IRAK2 Antibody: The pro-inflammatory cytokine IL-1 induces cellular response through two subunits of its receptor, IL-1 receptor I (IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 receptor-associated kinase (IRAK) mediates activation of NF-κB, which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in the IRAK/Pelle family has been identified and designated IRAK2. Both IRAK and IRAK2 recruit to the subunits of the IL-1R complex after IL-1 binding and lead to NF-κB activation. IRAKs also associate with Toll like receptor (TLR) and the dominant negative mutants of IRAKs inhibit LPS-induced NF-kB activation. Members in IRAK/Pelle family play a central role in IL-1R and TLR mediated inflammatory response. Unlike human IRAK2, murine IRAK2 exists as four alternately spliced isoforms (IRAK2a-d), with two isoforms (IRAK2c and d) acting in an inhibitory fashion. IRAK2 is expressed in a variety of tissues.
 Applications Tested/Suitable for anti-Irak2 antibody   

ELISA (EIA), Western Blot (WB), Immunocytochemistry (ICC), Immunofluorescence (IF)

 Application Notes for anti-Irak2 antibody    IRAK2 antibody can be used for detection of mouse IRAK2 by Western blot at 0.5 - 2 mug/mL. A 65 kDa band should be detected. Antibody can also be used for immunocytochemistry starting at 1 mug/mL. For immunofluorescence start at 10 mug/mL.
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 Western Blot (WB) of anti-Irak2 antibody    Western blot analysis of IRAK2 in RAW264.7 whole cell lysate with mIRAK2 antibody at (A) 0.5, (B) 1, and (C) 2 μg/mL.
anti-Irak2 antibody Western Blot (WB) (WB) image
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 Immunocytochemistry (ICC) of anti-Irak2 antibody    Immunocytochemistry of IRAK2 in A-20 cells with IRAK2 antibody at 1 μg/mL.
anti-Irak2 antibody Immunocytochemistry (ICC) (ICC) image
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 Immunofluorescence (IF) of anti-Irak2 antibody    Immunofluorescence of IRAK2 in A20 cells with IRAK2 antibody at 10 μg/mL.
anti-Irak2 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for Irak2. It may not necessarily be applicable to this product.
 NCBI GI #    37725373
 NCBI GeneID    108960
 NCBI Accession #    AAO24761 [Other Products]
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 UniProt Primary Accession #    Q8CFA1 [Other Products]
 UniProt Secondary Accession #    Q3U3K2; Q3U7F5; Q3UFX2; Q5U404; Q6YBR8; Q6YBR9; Q6YBS0; Q6YBS1; Q8C5M0; Q8CC82; Q8CEA0 [Other Products]
 UniProt Related Accession #    Q8CFA1 [Other Products]
 Molecular Weight    52,463 Da
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 NCBI Official Full Name    interleukin-1 receptor-associated kinase 2a
 NCBI Official Synonym Full Names    interleukin-1 receptor-associated kinase 2
 NCBI Official Symbol    Irak2 [Similar Products]
 NCBI Official Synonym Symbols   
IRAK-2; AI649099; 6330415L08Rik
[Similar Products]
 NCBI Protein Information    interleukin-1 receptor-associated kinase-like 2; mu-IRAK-2; interleukin-1 receptor-associated kinase 2c
 UniProt Protein Name    Interleukin-1 receptor-associated kinase-like 2
 Protein Family    Interleukin-1 receptor-associated kinase
 UniProt Gene Name    Irak2 [Similar Products]
 UniProt Synonym Gene Names    IRAK-2; mu-IRAK-2 [Similar Products]
 UniProt Entry Name    IRAK2_MOUSE
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 UniProt Comments for Irak2    IRAK2: Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. Expressed in spleen, thymus, prostate, lung, liver, skeletal muscle, kidney, pancreas and peripheral blood leukocytes. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.

Protein type: Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; IRAK family

Cellular Component: interleukin-1 receptor complex; cytoplasm; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; protein homodimerization activity; protein heterodimerization activity; transferase activity, transferring phosphorus-containing groups; nucleotide binding; ATP binding; protein kinase activity

Biological Process: regulation of apoptosis; inhibition of NF-kappaB transcription factor; negative regulation of transcription factor activity; protein amino acid autophosphorylation; activation of NF-kappaB-inducing kinase; lipopolysaccharide-mediated signaling pathway; toll-like receptor signaling pathway; regulation of cytokine and chemokine mediated signaling pathway; signal transduction; protein amino acid phosphorylation; activation of NF-kappaB transcription factor
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 Research Articles on Irak2    1. These findings demonstrate an unexpected linkage of the innate immunity machinery to unfolded protein response signaling, revealing IRAK2 as a novel amplifier of the IRE1 pathway.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Irak2 antibodyDiseases associated with anti-Irak2 antibody
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Signaling Pathway antibodies  Apoptosis Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IL-1 Signaling Pathway antibodies  IL-1 Signaling Pathway Diagram
 IRAK2 Mediated Activation Of TAK1 Complex Pathway antibodies  IRAK2 Mediated Activation Of TAK1 Complex Pathway Diagram
 IRAK2 Mediated Activation Of TAK1 Complex Upon TLR7/8 Or 9 Stimulation Pathway antibodies  IRAK2 Mediated Activation Of TAK1 Complex Upon TLR7/8 Or 9 Stimulation Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >328 publications with Irak2 and Necrosis
 Inflammation Antibodies  >306 publications with Irak2 and Inflammation
 Disease Models, Animal Antibodies  >52 publications with Irak2 and Disease Models, Animal
 Lung Diseases Antibodies  >47 publications with Irak2 and Lung Diseases
 Nervous System Diseases Antibodies  >32 publications with Irak2 and Nervous System Diseases
 Skin Diseases Antibodies  >27 publications with Irak2 and Skin Diseases
 Lung Injury Antibodies  >20 publications with Irak2 and Lung Injury
 Liver Diseases Antibodies  >19 publications with Irak2 and Liver Diseases
 Pneumonia Antibodies  >16 publications with Irak2 and Pneumonia
 Heart Diseases Antibodies  >15 publications with Irak2 and Heart Diseases
Organs/Tissues associated with anti-Irak2 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >278 publications with Irak2 and Blood
 Lung Antibodies  >73 publications with Irak2 and Lung
 Bone Antibodies  >57 publications with Irak2 and Bone
 Liver Antibodies  >43 publications with Irak2 and Liver
 Kidney Antibodies  >41 publications with Irak2 and Kidney
 Bone Marrow Antibodies  >40 publications with Irak2 and Bone Marrow
 Brain Antibodies  >31 publications with Irak2 and Brain
 Spleen Antibodies  >29 publications with Irak2 and Spleen
 Intestine Antibodies  >27 publications with Irak2 and Intestine
 Skin Antibodies  >24 publications with Irak2 and Skin
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