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anti-IRAK4 antibody :: Rabbit IRAK4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS176135
Western Blot (WB)
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IRAK4, Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-IRAK4 antibody

 Product Synonym Names    Interleukin-1 receptor-associated kinase 4; interleukin-1 receptor-associated kinase 4; IL-1 receptor-associated kinase 4 antibody; Interleukin 1 receptor associated kinase 4 mutant form 1 antibody; Interleukin-1 receptor-associated kinase 4 antibody; Interleukin1 receptor associated kinase 4 antibody; IPD1 antibody; IRAK 4 antibody; IRAK-4 antibody; IRAK4 antibody; IRAK4 mutated form 1 antibody; IRAK4_HUMAN antibody; LOC 51135 antibody; NY REN 64 antibody; NY REN 64 antigen antibody; NY-REN-64 antibody; REN64 antibody; Renal carcinoma antigen NY-REN-64 antibody
 Product Gene Name   

anti-IRAK4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    610799
 3D Structure    ModBase 3D Structure for Q9NWZ3
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the N-terminus of human IRAK4 (45-59aa DDRYNQFHIRRFEAL), identical to the related rat and mouse sequences.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-IRAK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IRAK4 antibody

   Description: Rabbit IgG polyclonal antibody for Interleukin-1 receptor-associated kinase 4(IRAK4) detection. Tested with WB in Human, Mouse, Rat.
Background: IRAK-4(interleukin-1 receptor-associated kinase 4), also called REN64, in the IRAK family, is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors. Scott(2002) mapped the REN64/IRAK4 gene to chromosome 12 based on similarity between the REN64 sequence(GenBank AF155118) and a chromosome 12 clone(GenBank AC093012). Functional analysis by Li et al.(2002) determined that IRAK4, like IRAK1 and Pelle, has auto- and cross-phosphorylation kinase activity. Precipitation and binding analyses showed weak interaction between IRAK4 and IRAK1, but IRAK4 did not interact with other IRAK family members. Overexpressed IRAK4 interacted with MYD88 and TRAF6 and activated mitogen-activated protein kinase(MAPK) and nuclear factor kappa-B(NFKB) pathways.
 Applications Tested/Suitable for anti-IRAK4 antibody   

Western Blot (WB)

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 Western Blot (WB) of anti-IRAK4 antibody    Anti-IRAK4 antibody, MBS176135, Western blotting
Lane 1: HELA Cell Lysate
Lane 2: U87 Cell Lysate
Lane 3: MCF-7 Cell Lysate

anti-IRAK4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for IRAK4. It may not necessarily be applicable to this product.
 NCBI GI #    50401181
 NCBI GeneID    51135
 NCBI Accession #    Q9NWZ3.1 [Other Products]
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 UniProt Primary Accession #    Q9NWZ3 [Other Products]
 UniProt Secondary Accession #    Q69FE1; Q8TDF7; Q9Y589 [Other Products]
 UniProt Related Accession #    Q9NWZ3 [Other Products]
 Molecular Weight    37,674 Da
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 NCBI Official Full Name    Interleukin-1 receptor-associated kinase 4
 NCBI Official Synonym Full Names    interleukin-1 receptor-associated kinase 4
 NCBI Official Symbol    IRAK4 [Similar Products]
 NCBI Official Synonym Symbols   
IPD1; REN64; IRAK-4; NY-REN-64
[Similar Products]
 NCBI Protein Information    interleukin-1 receptor-associated kinase 4; renal carcinoma antigen NY-REN-64
 UniProt Protein Name    Interleukin-1 receptor-associated kinase 4
 UniProt Synonym Protein Names   
Renal carcinoma antigen NY-REN-64
 Protein Family    Interleukin-1 receptor-associated kinase
 UniProt Gene Name    IRAK4 [Similar Products]
 UniProt Synonym Gene Names    IRAK-4 [Similar Products]
 UniProt Entry Name    IRAK4_HUMAN
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 NCBI Summary for IRAK4    This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
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 UniProt Comments for IRAK4    IRAK4: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs.

Protein type: EC 2.7.11.1; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; TKL group; IRAK family

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: extracellular space; cytoplasm; plasma membrane; endosome membrane; cytosol; nucleus

Molecular Function: protein serine/threonine kinase activity; protein binding; interleukin-1 receptor binding; magnesium ion binding; ATP binding; protein kinase activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; cytokine and chemokine mediated signaling pathway; positive regulation of smooth muscle cell proliferation; cytokine production; protein amino acid phosphorylation; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 5 signaling pathway; MyD88-dependent toll-like receptor signaling pathway; toll-like receptor signaling pathway; JNK cascade; innate immune response; toll-like receptor 9 signaling pathway; toll-like receptor 4 signaling pathway

Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 1; Irak4 Deficiency
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 Research Articles on IRAK4    1. these studies suggest that not only the loss of protein expression but also the defect of Myddosome formation couldcause IRAK4 and MyD88 deficiency syndromes.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IRAK4 antibodyPathways associated with anti-IRAK4 antibody
 Reference Product  PubMed Publications
 IRAK2 antibody  >181 publications with IRAK4 and IRAK2
 MYD88 antibody  >107 publications with IRAK4 and MYD88
 IRAK1 antibody  >66 publications with IRAK4 and IRAK1
 TLR4 antibody  >65 publications with IRAK4 and TLR4
 TRAF6 antibody  >45 publications with IRAK4 and TRAF6
 TIRAP antibody  >7 publications with IRAK4 and TIRAP
 PELI1 antibody  >5 publications with IRAK4 and PELI1
 PELI2 antibody  >1 publications with IRAK4 and PELI2
 IL1R1 antibody  >1 publications with IRAK4 and IL1R1
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 IL-1 Signaling Pathway antibodies  IL-1 Signaling Pathway Diagram
 IL1-mediated Signaling Events Pathway antibodies  IL1-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with anti-IRAK4 antibodyOrgans/Tissues associated with anti-IRAK4 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >66 publications with IRAK4 and Inflammation
 Necrosis Antibodies  >47 publications with IRAK4 and Necrosis
 Death Antibodies  >35 publications with IRAK4 and Death
 Autoimmune Diseases Antibodies  >14 publications with IRAK4 and Autoimmune Diseases
 Disease Models, Animal Antibodies  >12 publications with IRAK4 and Disease Models, Animal
 Nervous System Diseases Antibodies  >11 publications with IRAK4 and Nervous System Diseases
 IRAK4 Deficiency Antibodies  >10 publications with IRAK4 and IRAK4 Deficiency
 Immunoproliferative Disorders Antibodies  >7 publications with IRAK4 and Immunoproliferative Disorders
 Congenital Abnormalities Antibodies  >5 publications with IRAK4 and Congenital Abnormalities
 Abnormalities, Multiple Antibodies  >5 publications with IRAK4 and Abnormalities, Multiple
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >77 publications with IRAK4 and Blood
 Bone Antibodies  >14 publications with IRAK4 and Bone
 Lung Antibodies  >14 publications with IRAK4 and Lung
 Bone Marrow Antibodies  >12 publications with IRAK4 and Bone Marrow
 Brain Antibodies  >9 publications with IRAK4 and Brain
 Intestine Antibodies  >8 publications with IRAK4 and Intestine
 Liver Antibodies  >8 publications with IRAK4 and Liver
 Vascular Antibodies  >7 publications with IRAK4 and Vascular
 Kidney Antibodies  >7 publications with IRAK4 and Kidney
 Skin Antibodies  >7 publications with IRAK4 and Skin
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