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anti-IRF-3 antibody :: Rabbit IRF-3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9502591
Western Blot (WB)
Unit / Price
0.05 mg  /  $225 +1 FREE 8GB USB
0.1 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IRF-3, Polyclonal Antibody

★Popular Item★
 Also Known As   

IRF-3 (Phospho-Ser396) Antibody

 Product Synonym Names    Interferon regulatory factor 3; IRF3
 Product Gene Name   

anti-IRF-3 antibody

[Similar Products]
 Product Synonym Gene Name    IRF3 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    Z56281 mRNA
 3D Structure    ModBase 3D Structure for Q14653
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    IRF-3 (Phospho-Ser396) Antibody detects endogenous levels of IRF-3 only when phosphorylated at Ser396.
 Purity/Purification    Purified from rabbit antiserum by affinity-chromatography using phospho peptide. The antibody against non-phospho peptide was removed by chromatography using corresponding non-phospho peptide.
 Form/Format    Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
 Concentration    1 mg/ml (lot specific)
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 Target Modification    Phospho
 Modification Sites    H:S396; M:S388; R:S390
 Immunogen    The antiserum was produced against synthesized peptide derived from human IRF-3 around the phosphorylation site of Ser396.
 Immunogen Range    362-411
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 Preparation and Storage    Stable at -20 degree C for at least 1 year.
 Other Notes    Small volumes of anti-IRF-3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IRF-3 antibody   

Western Blot (WB), ELISA (EIA)

 Application Notes for anti-IRF-3 antibody    WB: 1:500~1:1000
ELISA: 1:20000
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 Western Blot (WB) of anti-IRF-3 antibody    Western blot analysis of lysates from Jurkat cells treated with EGF 200ng/ml 30', using IRF-3 (Phospho-Ser396) Antibody. The lane on the right is blocked with the phospho peptide.
anti-IRF-3 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for IRF-3. It may not necessarily be applicable to this product.
 NCBI GI #    308199446
 NCBI GeneID    3661
 NCBI Accession #    NP_001184051.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001197122.1 [Other Products]
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 UniProt Primary Accession #    Q14653 [Other Products]
 UniProt Secondary Accession #    Q5FBY1; Q5FBY2; Q5FBY4; Q7Z5G6; A8K7L2; B2RAZ3 [Other Products]
 UniProt Related Accession #    Q14653 [Other Products]
 Molecular Weight    47 kDa
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 NCBI Official Full Name    interferon regulatory factor 3 isoform 2
 NCBI Official Synonym Full Names    interferon regulatory factor 3
 NCBI Official Symbol    IRF3 [Similar Products]
 NCBI Official Synonym Symbols   
IIAE7
[Similar Products]
 NCBI Protein Information    interferon regulatory factor 3
 UniProt Protein Name    Interferon regulatory factor 3
 UniProt Gene Name    IRF3 [Similar Products]
 UniProt Synonym Gene Names    IRF-3 [Similar Products]
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 NCBI Summary for IRF-3    This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
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 UniProt Comments for IRF-3    Key transcriptional regulator of type I interferon (IFN)-dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
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 Research Articles on IRF-3    1. IRF-3 gene polymorphisms were associated with the susceptibility and prognosis of CLL, it can be used as an auxiliary index for clinical detection of CLL.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IRF-3 antibodyPathways associated with anti-IRF-3 antibody
 Reference Product  PubMed Publications
 TBK1 antibody  >176 publications with IRF-3 and TBK1
 JUN antibody  >123 publications with IRF-3 and JUN
 MAVS antibody  >76 publications with IRF-3 and MAVS
 IRF5 antibody  >37 publications with IRF-3 and IRF5
 IKBKE antibody  >27 publications with IRF-3 and IKBKE
 CREBBP antibody  >13 publications with IRF-3 and CREBBP
 IFNB1 antibody  >12 publications with IRF-3 and IFNB1
 EP300 antibody  >6 publications with IRF-3 and EP300
 PIN1 antibody  >5 publications with IRF-3 and PIN1
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Antiviral Mechanism By IFN-stimulated Genes Pathway antibodies  Antiviral Mechanism By IFN-stimulated Genes Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
Diseases associated with anti-IRF-3 antibodyOrgans/Tissues associated with anti-IRF-3 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >152 publications with IRF-3 and Inflammation
 Necrosis Antibodies  >117 publications with IRF-3 and Necrosis
 Death Antibodies  >51 publications with IRF-3 and Death
 Neoplasms Antibodies  >50 publications with IRF-3 and Neoplasms
 Liver Diseases Antibodies  >45 publications with IRF-3 and Liver Diseases
 Cardiovascular Diseases Antibodies  >23 publications with IRF-3 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >16 publications with IRF-3 and Kidney Diseases
 Carcinoma Antibodies  >15 publications with IRF-3 and Carcinoma
 Neoplasms, Experimental Antibodies  >9 publications with IRF-3 and Neoplasms, Experimental
 Drug Toxicity Antibodies  >8 publications with IRF-3 and Drug Toxicity
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >137 publications with IRF-3 and Blood
 Liver Antibodies  >52 publications with IRF-3 and Liver
 Bone Antibodies  >49 publications with IRF-3 and Bone
 Kidney Antibodies  >39 publications with IRF-3 and Kidney
 Lung Antibodies  >37 publications with IRF-3 and Lung
 Brain Antibodies  >24 publications with IRF-3 and Brain
 Skin Antibodies  >22 publications with IRF-3 and Skin
 Spleen Antibodies  >21 publications with IRF-3 and Spleen
 Vascular Antibodies  >17 publications with IRF-3 and Vascular
 Intestine Antibodies  >10 publications with IRF-3 and Intestine
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