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anti-IRF5 antibody :: Rabbit IRF5 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2529606
Unit / Price
0.06 mL  /  $195 +1 FREE 8GB USB
0.12 mL  /  $270 +1 FREE 8GB USB
0.2 mL  /  $435 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IRF5, Polyclonal Antibody

★Popular Item★
 Also Known As   

IRF5 Antibody

 Product Synonym Names    IRF5; SLEB10
 Product Gene Name   

anti-IRF5 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    180300
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity purification
 Concentration    1mg/mL (lot specific)
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 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-98651
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 Preparation and Storage    Store at -20 degree C, Avoid freeze / thaw cycles
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-IRF5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IRF5 antibody

   Background/Introduction: Interferon regulatory factors (IRFs) comprise a family of transcription factors that function within the Jak/Stat pathway to regulate interferon (IFN) and IFN-inducible gene expression in response to viral infection (1). IRFs play an important role in pathogen defense, autoimmunity, lymphocyte development, cell growth, and susceptibility to transformation. The IRF family includes nine members: IRF-1, IRF-2, ISGF3gamma/p48, IRF-3, IRF-4 (Pip/LSIRF/ICSAT), IRF-5, IRF-6, IRF-7, and IRF-8/ICSBP. All IRF proteins share homology in their amino-terminal DNA-binding domains. IRF family members regulate transcription through interactions with proteins that share similar DNA-binding motifs, such as IFN-stimulated response elements (ISRE), IFN consensus sequences (ICS), and IFN regulatory elements (IRF-E) (2).IRF-5 is expressed in lymphoid tissues and peripheral blood lymphocytes and participates in the induction of type I interferon genes following viral infection (3). Activation of IRF-5 signaling is triggered by the toll-like receptor (TLR) pathway, including TLR7 and MyD88 (4,5). Genetic variants of IRF-5 have been associated with disorders where the IFN pathway is abnormally activated, such as systemic lupus erythematosus (6,7).
 Applications Tested/Suitable for anti-IRF5 antibody   

Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

 Application Notes for anti-IRF5 antibody    WB: 1:500-1:2000,IHC: 1:50-1:200,IF :1:50-1:200
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 Western Blot (WB) of anti-IRF5 antibody    Western blot analysis of extracts of various cell lines, using IRF5 antibody.
anti-IRF5 antibody Western Blot (WB) (WB) image
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 Immunofluorescence (IF) of anti-IRF5 antibody    Immunofluorescence analysis of HeLa cell using IRF5 antibody. Blue: DAPI for nuclear staining.
anti-IRF5 antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for IRF5. It may not necessarily be applicable to this product.
 NCBI GI #    334883190
 NCBI GeneID    3663
 NCBI Accession #    NP_001229381.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001242452.2 [Other Products]
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 UniProt Secondary Accession #    Q1A7B4; Q64GA9; Q64GB1; Q64GB2; Q6RCM8; Q9BQF0; A4D1J8; A8DUA8; A8DUA9; E7EQ16; E7EW54 [Other Products]
 UniProt Related Accession #    Q13568 [Other Products]
 Molecular Weight    56kDa
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 NCBI Official Full Name    interferon regulatory factor 5 isoform e
 NCBI Official Synonym Full Names    interferon regulatory factor 5
 NCBI Official Symbol    IRF5 [Similar Products]
 NCBI Official Synonym Symbols   
SLEB10
[Similar Products]
 NCBI Protein Information    interferon regulatory factor 5
 UniProt Protein Name    Interferon regulatory factor 5
 Protein Family    Interferon regulatory factor
 UniProt Gene Name    IRF5 [Similar Products]
 UniProt Synonym Gene Names    IRF-5 [Similar Products]
 UniProt Entry Name    IRF5_HUMAN
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 NCBI Summary for IRF5    This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Multiple transcript variants encoding different isoforms have been found for this gene, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Mar 2010]
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 UniProt Comments for IRF5    IRF5: Transcription factor involved in the induction of interferons IFNA and INFB and inflammatory cytokines upon virus infection. Activated by TLR7 or TLR8 signaling. Homodimer, when phosphorylated. Belongs to the IRF family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 7q32

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; transcription factor activity

Biological Process: transcription, DNA-dependent; positive regulation of interleukin-12 production; positive regulation of apoptosis; response to muramyl dipeptide; cytokine and chemokine mediated signaling pathway; response to peptidoglycan; positive regulation of interferon-beta production; positive regulation of transcription from RNA polymerase II promoter; defense response to virus; positive regulation of interferon-alpha production

Disease: Systemic Lupus Erythematosus, Susceptibility To, 10; Inflammatory Bowel Disease 14
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 Research Articles on IRF5    1. results indicate that T3-bound TRs interfere with transactivation by TEADs via protein-protein interactions, resulting in the negative regulation of MYH7 promoter activity
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IRF5 antibodyPathways associated with anti-IRF5 antibody
 Reference Product  PubMed Publications
 IRF3 antibody  >40 publications with IRF5 and IRF3
 MYD88 antibody  >18 publications with IRF5 and MYD88
 TRAF6 antibody  >6 publications with IRF5 and TRAF6
 TBK1 antibody  >4 publications with IRF5 and TBK1
 STAT2 antibody  >4 publications with IRF5 and STAT2
 ISG15 antibody  >3 publications with IRF5 and ISG15
 IRF6 antibody  >3 publications with IRF5 and IRF6
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Direct P53 Effectors Pathway antibodies  Direct P53 Effectors Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram
 Regulation Of Toll-like Receptor Signaling Pathway antibodies  Regulation Of Toll-like Receptor Signaling Pathway Diagram
 Senescence And Autophagy Pathway antibodies  Senescence And Autophagy Pathway Diagram
 Toll-like Receptor Signaling Pathway antibodies  Toll-like Receptor Signaling Pathway Diagram
Diseases associated with anti-IRF5 antibodyOrgans/Tissues associated with anti-IRF5 antibody
 Disease Name  Pubmed Publications
 Lupus Erythematosus, Systemic Antibodies  >143 publications with IRF5 and Lupus Erythematosus, Systemic
 Arthritis, Rheumatoid Antibodies  >59 publications with IRF5 and Arthritis, Rheumatoid
 Inflammation Antibodies  >56 publications with IRF5 and Inflammation
 Necrosis Antibodies  >25 publications with IRF5 and Necrosis
 Scleroderma, Systemic Antibodies  >22 publications with IRF5 and Scleroderma, Systemic
 Fibrosis Antibodies  >13 publications with IRF5 and Fibrosis
 Liver Diseases Antibodies  >11 publications with IRF5 and Liver Diseases
 Colitis, Ulcerative Antibodies  >8 publications with IRF5 and Colitis, Ulcerative
 Atherosclerosis Antibodies  >8 publications with IRF5 and Atherosclerosis
 Kidney Diseases Antibodies  >7 publications with IRF5 and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >105 publications with IRF5 and Blood
 Bone Antibodies  >14 publications with IRF5 and Bone
 Bone Marrow Antibodies  >11 publications with IRF5 and Bone Marrow
 Spleen Antibodies  >9 publications with IRF5 and Spleen
 Connective Tissue Antibodies  >8 publications with IRF5 and Connective Tissue
 Kidney Antibodies  >8 publications with IRF5 and Kidney
 Lung Antibodies  >7 publications with IRF5 and Lung
 Mouth Antibodies  >6 publications with IRF5 and Mouth
 Brain Antibodies  >5 publications with IRF5 and Brain
 Lymph Node Antibodies  >3 publications with IRF5 and Lymph Node
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