Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource rightarrow Antibody rightarrow IRF6 rightarrow Polyclonal IRF6  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Menu separator
separator
ELISA Kit ELISA Kit
CLIA Kit CLIA Kit
PCR Kit PCR Kit
Monoclonal Antibody Monoclonal Antibody
Polyclonal Antibody Polyclonal Antibody
Secondary Antibody Secondary Antibody
Antigen Antigen
Biochemical Biochemical
cDNA Clone cDNA Clone
siRNA siRNA
Peptide Peptide
Recombinant/Purified Protein Rec./Purified Protein

Custom ELISA Kit Custom ELISA Kit
Custom Protein Custom Protein
Custom Antibody Custom Antibody
Antibody Matched Pairs Antibody Matched Pairs
Antibody & Corresponding Blocking Peptide Pairs Antibody Peptide Pairs
Phospho-Specific Antibodies Phospho Antibodies
Products by Disease Products by Disease
Products by Pathway Products by Pathway
Products by Tissue Products by Tissue

arrow Advanced Search
arrow Submit Technical Q&A
arrow International Distributors
arrow Contact Us
separator
Our Best Sellers moreseparator
separator
 • odz, odd Oz-ten-m homolog 4 (Drosophila) (ODZ4) ELISA Kit
 • Desmosine ELISA Kit
 • Retinol Binding Protein-4 (RBP4) Recombinant Protein
 • Ro-SS-A Antigen Antigen
 • Dipeptidyl peptidase 4 (CD26) ELISA Kit
 • Alpha-1-Antichymotrypsin (alpha1ACT) ELISA Kit
 • Terminal Complement Complex C5b-9 (C5b-9) ELISA Kit
 • Collagen VI Antibody
 • KIR2DL1(p58 KIR, p58.1, CD158, cl-42, KIR-K6, NKAT1, NKR-K6,... Antibody
 • Ornithine decarboxylase (ODC) Recombinant Protein
 • AKT3 Antibody
 • Visfatin (VF) ELISA Kit
 • DUSP11 cDNA Clone
 • p300 (EP300) Blocking Peptide
 downarrow more ...
separator
separator
DatasheetFull DatasheetPrinter Friendly DatasheetPrint This DatasheetAdd to Compare ListHave Questions? Ask UsRequest for a Quotation today

anti-IRF6 antibody :: Rabbit IRF6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2524084
Unit / Price
0.02 mL  /  $110 +1 FREE 8GB USB
0.06 mL  /  $150 +1 FREE 8GB USB
0.12 mL  /  $225 +1 FREE 8GB USB
0.2 mL  /  $360 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IRF6, Polyclonal Antibody

 Also Known As   

IRF6 Polyclonal Antibody

 Product Synonym Names    LPS; PIT; PPS; VWS; OFC6; PPS1; VWS1
 Product Gene Name   

anti-IRF6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
Table BarTOPTable Bar
 OMIM    119300
Section Bar
 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
Section Bar
 Purity/Purification    Antigen affinity purification
 Concentration    2.3mg/mL (lot specific)
Section Bar
 Immunogen    Recombinant protein of human IRF6
 Calculated Molecular Weight: 53kDa   
 Buffer    PBS with 0.05% sodium azide, 50% glycerol, pH7.3
Section Bar
 Preparation and Storage    Store at -20 degree C (regular) and -80 degree C (long term). Avoid freeze / thaw cycles.
 Other Notes    Small volumes of anti-IRF6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
Table BarTOPTable Bar
 

Product Description specifically for anti-IRF6 antibody

   This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.
 Product Categories/Family for anti-IRF6 antibody    Stem cells
 Applications Tested/Suitable for anti-IRF6 antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-IRF6 antibody    WB: 1:200-1:1000
IHC: 1:50-1:200
Section Bar
 Western Blot (WB) of anti-IRF6 antibody    Western Blot analysis of 231 cell, Mouse kidney and lung tissue using IRF6 Polyclonal Antibody at dilution of 1:400
anti-IRF6 antibody Western Blot (WB) (WB) image
Section Bar
 Immunohistochemistry (IHC) of anti-IRF6 antibody    Immunohistochemistry of paraffin-embedded Human cervical cancer using IRF6 Polyclonal Antibody at dilution of 1:50
anti-IRF6 antibody Immunohistochemistry (IHC) (IHC) image
Section Bar
 Immunohistochemistry (IHC) of anti-IRF6 antibody    Immunohistochemistry of paraffin-embedded Human lung cancer using IRF6 Polyclonal Antibody at dilution of 1:50
anti-IRF6 antibody Immunohistochemistry (IHC) (IHC) image
Table BarTOPTable Bar
NCBI/Uniprot data below describe general gene information for IRF6. It may not necessarily be applicable to this product.
 NCBI GI #    331999978
 NCBI GeneID    3664
 NCBI Accession #    NP_001193625.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001206696.1 [Other Products]
Section Bar
 UniProt Secondary Accession #    B4DLE2; D3DT90; F5GWX8; G0ZTL0 [Other Products]
 UniProt Related Accession #    O14896 [Other Products]
 Molecular Weight    41,930 Da
Table BarTOPTable Bar
 NCBI Official Full Name    interferon regulatory factor 6 isoform 2
 NCBI Official Synonym Full Names    interferon regulatory factor 6
 NCBI Official Symbol    IRF6 [Similar Products]
 NCBI Official Synonym Symbols   
LPS; PIT; PPS; VWS; OFC6; PPS1; VWS1
[Similar Products]
 NCBI Protein Information    interferon regulatory factor 6
 UniProt Protein Name    Interferon regulatory factor 6
 Protein Family    Interferon regulatory factor
 UniProt Gene Name    IRF6 [Similar Products]
 UniProt Synonym Gene Names    IRF-6 [Similar Products]
 UniProt Entry Name    IRF6_HUMAN
Section Bar
 NCBI Summary for IRF6    This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]
Section Bar
 UniProt Comments for IRF6    IRF6: Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development. Plays a role in regulating mammary epithelial cell proliferation. May regulate WDR65 transcription. Interacts with SERPINB5. Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. Belongs to the IRF family.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 1q32.3-q41

Cellular Component: cytoplasm; cytosol; nucleus

Molecular Function: protein binding; DNA binding; transcription factor activity

Biological Process: keratinocyte differentiation; negative regulation of cell proliferation; transcription, DNA-dependent; cytokine and chemokine mediated signaling pathway; positive regulation of transcription, DNA-dependent; keratinocyte proliferation; cell cycle arrest; cell development

Disease: Orofacial Cleft 6, Susceptibility To; Popliteal Pterygium Syndrome; Van Der Woude Syndrome 1
Table BarTOPTable Bar
 Research Articles on IRF6    1. Ser-413 and Ser-424 in IRF6 are important for its activation by RIPK4
Table BarTOPTable Bar
 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Table BarTOPTable Bar
Products associated with anti-IRF6 antibodyPathways associated with anti-IRF6 antibody
 Reference Product  PubMed Publications
 IRF2 antibody  >5 publications with IRF6 and IRF2
 IRF5 antibody  >3 publications with IRF6 and IRF5
 IRF8 antibody  >2 publications with IRF6 and IRF8
 CD44 antibody  >1 publications with IRF6 and CD44
 Products by Pathway  Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Interferon Signaling Pathway antibodies  Interferon Signaling Pathway Diagram
 Interferon Alpha/beta Signaling Pathway antibodies  Interferon Alpha/beta Signaling Pathway Diagram
 Interferon Gamma Signaling Pathway antibodies  Interferon Gamma Signaling Pathway Diagram
Diseases associated with anti-IRF6 antibodyOrgans/Tissues associated with anti-IRF6 antibody
 Disease Name  Pubmed Publications
 Cleft Palate Antibodies  >163 publications with IRF6 and Cleft Palate
 Cleft Lip Antibodies  >157 publications with IRF6 and Cleft Lip
 Craniofacial Abnormalities Antibodies  >137 publications with IRF6 and Craniofacial Abnormalities
 Van der Woude syndrome Antibodies  >83 publications with IRF6 and Van der Woude syndrome
 Popliteal Pterygium Syndrome Antibodies  >24 publications with IRF6 and Popliteal Pterygium Syndrome
 Skin Abnormalities Antibodies  >11 publications with IRF6 and Skin Abnormalities
 Limb Deformities, Congenital Antibodies  >8 publications with IRF6 and Limb Deformities, Congenital
 OROFACIAL CLEFT 6, SUSCEPTIBILITY TO Antibodies  >7 publications with IRF6 and OROFACIAL CLEFT 6, SUSCEPTIBILITY TO
 Urogenital Abnormalities Antibodies  >3 publications with IRF6 and Urogenital Abnormalities
 Cardiovascular Diseases Antibodies  >3 publications with IRF6 and Cardiovascular Diseases
 Organ/Tissue Name  Pubmed Publications
 Mouth Antibodies  >51 publications with IRF6 and Mouth
 Skin Antibodies  >24 publications with IRF6 and Skin
 Embryonic Tissue Antibodies  >9 publications with IRF6 and Embryonic Tissue
 Brain Antibodies  >4 publications with IRF6 and Brain
 Mammary Gland Antibodies  >3 publications with IRF6 and Mammary Gland
 Eye Antibodies  >3 publications with IRF6 and Eye
 Heart Antibodies  >3 publications with IRF6 and Heart
 Nerve Antibodies  >2 publications with IRF6 and Nerve
 Muscle Antibodies  >2 publications with IRF6 and Muscle
 Liver Antibodies  >2 publications with IRF6 and Liver
Table BarTOPTable Bar
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions