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anti-IRF7 antibody :: Rabbit anti-Human IRF7 / IRF-7 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS241288
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IRF7 / IRF-7, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human IRF7 / IRF-7

 Product Synonym Names    Anti-IRF7 / IRF-7 Antibody (Internal) IHC-plus; IRF7; Interferon regulatory factor 7; IRF-7; IRF7A; IRF-7H; Human IRF7; IRF-7
 Product Gene Name   

anti-IRF7 antibody

[Similar Products]
 Product Synonym Gene Name    IRF-7 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    605047
 3D Structure    ModBase 3D Structure for Q92985
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    peptide corresponding to 14 amino acids near the center of human IRF7
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide from human IRF7.
 Immunogen Type    Synthetic peptide
 Immunogen    IRF7 / IRF-7 antibody was raised against synthetic peptide from human IRF7.
 Antigen Modification    Internal
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
 Other Notes    Small volumes of anti-IRF7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-IRF7 antibody

   IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established.
 Applications Tested/Suitable for anti-IRF7 antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB)

 Application Notes for anti-IRF7 antibody    IHC-P (5 ug/ml), WB (1 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-IRF7 antibody    Anti-IRF7 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-IRF7 antibody Immunohistochemistry (IHC) (IHC) image
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 Western Blot (WB) of anti-IRF7 antibody    Western blot of IRF7 in 293 whole cell lysate with IRF7 antibody at (A) 0.5 and (B) 1 ug/ml.
anti-IRF7 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for IRF7. It may not necessarily be applicable to this product.
 NCBI GI #    98985819
 NCBI GeneID    3665
 NCBI Accession #    NP_004022.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_004031.2 [Other Products]
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 UniProt Primary Accession #    Q92985 [Other Products]
 UniProt Secondary Accession #    O00331; O00332; O00333; O75924; Q9UE79; B9EGL3 [Other Products]
 UniProt Related Accession #    Q92985 [Other Products]
 Molecular Weight    55,635 Da
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 NCBI Official Full Name    interferon regulatory factor 7 isoform d
 NCBI Official Synonym Full Names    interferon regulatory factor 7
 NCBI Official Symbol    IRF7 [Similar Products]
 NCBI Official Synonym Symbols   
IRF7A; IRF7B; IRF7C; IRF7H; IRF-7H
[Similar Products]
 NCBI Protein Information    interferon regulatory factor 7; IRF-7; interferon regulatory factor-7H
 UniProt Protein Name    Interferon regulatory factor 7
 Protein Family    Interferon regulatory factor
 UniProt Gene Name    IRF7 [Similar Products]
 UniProt Synonym Gene Names    IRF-7 [Similar Products]
 UniProt Entry Name    IRF7_HUMAN
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 NCBI Summary for IRF7    IRF7 encodes interferon regulatory factor 7, a member of the interferon regulatory transcription factor (IRF) family. IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. Inducible expression of IRF7 is largely restricted to lymphoid tissue. Multiple IRF7 transcript variants have been identified, although the functional consequences of these have not yet been established. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IRF7    IRF7: Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent pathway. Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages. Monomer. Homodimer; phosphorylation-induced. Heterodimer with IRF3. Interacts with TICAM1 and TICAM2. Interacts with rotavirus A NSP1; this interaction leads to the proteasome- dependent degradation of IRF7. Interacts with Epstein-Barr virus LF2. Interacts with MYD88 AND TRAF6. By type I interferon (IFN) and viruses. Expressed predominantly in spleen, thymus and peripheral blood leukocytes. In the absence of viral infection, maintained as a monomer in an autoinhibited state and phosphorylation disrupts this autoinhibition leading to the liberation of the DNA- binding and dimerization activities and its nuclear localization where it can activate type I IFN and ISG genes. Belongs to the IRF family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 11p15.5

Cellular Component: nucleoplasm; cytoplasm; endosome membrane; cytosol; nucleus

Molecular Function: protein binding; DNA binding

Biological Process: transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; establishment of viral latency; toll-like receptor 3 signaling pathway; negative regulation of transcription from RNA polymerase II promoter; regulation of adaptive immune response; regulation of MyD88-independent toll-like receptor signaling pathway; positive regulation of interferon type I production; positive regulation of interferon-beta production; interferon type I biosynthetic process; toll-like receptor 4 signaling pathway; positive regulation of interferon-alpha production; regulation of interferon type I production; regulation of immune response; response to virus; cytokine and chemokine mediated signaling pathway; MyD88-independent toll-like receptor signaling pathway; interferon-alpha production; regulation of MyD88-dependent toll-like receptor signaling pathway; regulation of monocyte differentiation; toll-like receptor signaling pathway; innate immune response; positive regulation of transcription from RNA polymerase II promoter; toll-like receptor 9 signaling pathway; immunoglobulin mediated immune response; response to DNA damage stimulus; interferon-beta production

Disease: Immunodeficiency 39
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 Research Articles on IRF7    1. Interferon regulatory factor (IRF)-3 and -7 are the key transcriptional factors for the induction of IL-28A and IL-28B genes, whereas NF-kappaB is an additional requirement for the induction of the IL-29 gene.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IRF7 antibodyPathways associated with anti-IRF7 antibody
 Reference Product  PubMed Publications
 MYD88 antibody  >80 publications with IRF7 and MYD88
 TBK1 antibody  >48 publications with IRF7 and TBK1
 ISG15 antibody  >27 publications with IRF7 and ISG15
 TRAF6 antibody  >27 publications with IRF7 and TRAF6
 MX1 antibody  >21 publications with IRF7 and MX1
 IRAK1 antibody  >10 publications with IRF7 and IRAK1
 IFIT3 antibody  >8 publications with IRF7 and IFIT3
 IFIT2 antibody  >5 publications with IRF7 and IFIT2
 OAS2 antibody  >2 publications with IRF7 and OAS2
 Products by Pathway  Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway antibodies  Activation Of IRF3/IRF7 Mediated By TBK1/IKK Epsilon Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic DNA-sensing Pathway antibodies  Cytosolic DNA-sensing Pathway Diagram
 Cytosolic Sensors Of Pathogen-associated DNA Pathway antibodies  Cytosolic Sensors Of Pathogen-associated DNA Pathway Diagram
 DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway antibodies  DEx/H-box Helicases Activate Type I IFN And Inflammatory Cytokines Production Pathway Diagram
 Factors Involved In Megakaryocyte Development And Platelet Production Pathway antibodies  Factors Involved In Megakaryocyte Development And Platelet Production Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-IRF7 antibodyOrgans/Tissues associated with anti-IRF7 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >77 publications with IRF7 and Inflammation
 Necrosis Antibodies  >70 publications with IRF7 and Necrosis
 Liver Diseases Antibodies  >34 publications with IRF7 and Liver Diseases
 Disease Models, Animal Antibodies  >20 publications with IRF7 and Disease Models, Animal
 Influenza, Human Antibodies  >18 publications with IRF7 and Influenza, Human
 Neoplasms, Experimental Antibodies  >11 publications with IRF7 and Neoplasms, Experimental
 Cardiovascular Diseases Antibodies  >9 publications with IRF7 and Cardiovascular Diseases
 Kidney Diseases Antibodies  >8 publications with IRF7 and Kidney Diseases
 Adenocarcinoma Antibodies  >8 publications with IRF7 and Adenocarcinoma
 Liver Neoplasms Antibodies  >7 publications with IRF7 and Liver Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >149 publications with IRF7 and Blood
 Liver Antibodies  >35 publications with IRF7 and Liver
 Spleen Antibodies  >32 publications with IRF7 and Spleen
 Bone Antibodies  >31 publications with IRF7 and Bone
 Brain Antibodies  >28 publications with IRF7 and Brain
 Bone Marrow Antibodies  >27 publications with IRF7 and Bone Marrow
 Lung Antibodies  >27 publications with IRF7 and Lung
 Kidney Antibodies  >22 publications with IRF7 and Kidney
 Skin Antibodies  >17 publications with IRF7 and Skin
 Intestine Antibodies  >10 publications with IRF7 and Intestine
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