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anti-IRGM antibody :: Rabbit IRGM / LRG-47 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242472
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IRGM / LRG-47, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human IRGM / LRG-47

 Product Synonym Names    Anti-IRGM / LRG-47 Antibody (Internal) IHC-plus; IRGM; LRG-47-like protein; IFI1; Interferon-inducible protein 1; IRGM1; LRG47; LRG-47; Human IRGM; LRG-47
 Product Gene Name   

anti-IRGM antibody

[Similar Products]
 Product Synonym Gene Name    LRG-47 [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 612278
 3D Structure    ModBase 3D Structure for A1A4Y4
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.02% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    14 amino acid peptide near the center of the human IRGM.
 Immunogen    IRGM / LRG-47 antibody was raised against 14 amino acid peptide near the center of the human IRGM.
 Antigen Modification    Internal
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 Preparation and Storage    Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
 Other Notes    Small volumes of anti-IRGM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IRGM antibody   

Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)

 Application Notes for anti-IRGM antibody    ELISA, IHC-P (5 ug/ml), WB (1 - 2 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-IRGM antibody    Anti-IRGM antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
anti-IRGM antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-IRGM antibody    Immunofluorescence of IRGM in Human Brain cells with IRGM antibody at 20 ug/ml.
anti-IRGM antibody Immunofluorescence (IF) image
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 Western Blot (WB) of anti-IRGM antibody    Western blot of IRGM in human brain lysate with IRGM antibody at (A) 1 and (B) 2 ug/ml.
anti-IRGM antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for IRGM. It may not necessarily be applicable to this product.
 NCBI GI #    224809576
 NCBI GeneID    345611
 NCBI Accession #    NP_001139277.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001145805.1 [Other Products]
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 UniProt Primary Accession #    A1A4Y4 [Other Products]
 UniProt Secondary Accession #    B3VEX0 [Other Products]
 UniProt Related Accession #    A1A4Y4 [Other Products]
 Molecular Weight    20,142 Da
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 NCBI Official Full Name    immunity-related GTPase family M protein
 NCBI Official Synonym Full Names    immunity-related GTPase family, M
 NCBI Official Symbol    IRGM [Similar Products]
 NCBI Official Synonym Symbols   
IFI1; IRGM1; LRG47; LRG-47
[Similar Products]
 NCBI Protein Information    immunity-related GTPase family M protein; LRG-47-like protein; interferon-inducible protein 1; immunity-related GTPase family, M1; LPS-stimulated RAW 264.7 macrophage protein 47 homolog
 UniProt Protein Name    Immunity-related GTPase family M protein
 UniProt Synonym Protein Names   
Immunity-related GTPase family M protein 1; Interferon-inducible protein 1; LPS-stimulated RAW 264.7 macrophage protein 47 homolog; LRG-47
 Protein Family    Immunity-related GTPase family M protein
 UniProt Gene Name    IRGM [Similar Products]
 UniProt Synonym Gene Names    IFI1; IRGM1; LRG47; LRG-47 [Similar Products]
 UniProt Entry Name    IRGM_HUMAN
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 NCBI Summary for IRGM    This gene encodes a member of the p47 immunity-related GTPase family. The encoded protein may play a role in the innate immune response by regulating autophagy formation in response to intracellular pathogens. Polymorphisms that affect the normal expression of this gene are associated with a susceptibility to Crohn's disease and tuberculosis.[provided by RefSeq, Oct 2010]
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 UniProt Comments for IRGM    IRGM: Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility. Defects in IRGM are the cause of susceptibility to inflammatory bowel disease type 19 (IBD19). A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Belongs to the interferon-inducible GTPase family.

Protein type: Endoplasmic reticulum; EC 3.6.5.-; Hydrolase

Chromosomal Location of Human Ortholog: 5q33.1

Cellular Component: Golgi membrane; phagocytic vesicle membrane; cell projection; phagocytic cup

Molecular Function: GTP binding; hydrolase activity

Biological Process: autophagy; innate immune response; inflammatory response

Disease: Mycobacterium Tuberculosis, Susceptibility To; Inflammatory Bowel Disease 19
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 Research Articles on IRGM    1. Despite moderate effects on the modulation of proinflammatory cytokine production, genetic variation in the autophagy genes ATG16L1 and IRGM has a minor impact on the susceptibility to both mucosal and systemic Candida infections.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IRGM antibodyPathways associated with anti-IRGM antibody
 Reference Product  PubMed Publications
 ATG16L1 antibody  >69 publications with IRGM and ATG16L1
 NOD2 antibody  >50 publications with IRGM and NOD2
 IL23R antibody  >24 publications with IRGM and IL23R
 NKX2-3 antibody  >12 publications with IRGM and NKX2-3
 TSPAN8 antibody  >1 publications with IRGM and TSPAN8
 ZNF300 antibody  >1 publications with IRGM and ZNF300
 Products by Pathway  Pathway Diagram
 Toxoplasmosis Pathway antibodies  Toxoplasmosis Pathway Diagram
 Toxoplasmosis Pathway antibodies  Toxoplasmosis Pathway Diagram
Diseases associated with anti-IRGM antibody
 Disease Name  Pubmed Publications
 Crohn Disease Antibodies  >75 publications with IRGM and Crohn Disease
 Inflammation Antibodies  >33 publications with IRGM and Inflammation
 Colitis, Ulcerative Antibodies  >31 publications with IRGM and Colitis, Ulcerative
 Necrosis Antibodies  >11 publications with IRGM and Necrosis
 MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO Antibodies  >6 publications with IRGM and MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO
 Cardiovascular Diseases Antibodies  >3 publications with IRGM and Cardiovascular Diseases
 Musculoskeletal Diseases Antibodies  >3 publications with IRGM and Musculoskeletal Diseases
 Heart Diseases Antibodies  >1 publications with IRGM and Heart Diseases
 Liver Diseases Antibodies  >1 publications with IRGM and Liver Diseases
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