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anti-ITGA2 antibody :: Rabbit ITGA2 / CD49b Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS240182
Immunohistochemistry (IHC)
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ITGA2 / CD49b, Polyclonal Antibody

 Also Known As   

Rabbit Polyclonal to Human ITGA2 / CD49b

 Product Synonym Names    Anti-ITGA2 / CD49b Antibody (Extracellular Domain) IHC-plus; ITGA2; Alpha2 integrin; BR; CD49b antigen; CD49B; Integrin alpha2; Integrin Alpha 2; Integrin alpha-2; HPA-5; VLA-2; VLAA2; VLA-2 subunit alpha; Collagen receptor; GPIa; Platelet antigen Br; Platelet glycoprotein GPIa; VLA2 receptor; alpha-2 subunit; Human ITGA2; CD49b
 Product Gene Name   

anti-ITGA2 antibody

[Similar Products]
 Product Synonym Gene Name    CD49b [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    192974
 3D Structure    ModBase 3D Structure for P17301
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Gibbon, Dog, Gorilla, Human, Monkey, Pig
Predicted Reactivity: Bovine, Horse, Chicken (at least 90% immunogen sequence identity)
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 Specificity    Human ITGA2 / CD49b. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, 0.1% sodium azide.
 Concentration    0.7 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic 16 amino acid peptide from extracellular domain of human ITGA2 / CD49b. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Dog, Panda, Pig (100%); Bovine, Elephant, Horse, Chicken, Lizard (94%).
 Immunogen Type    Synthetic peptide
 Immunogen    ITGA2 / CD49b antibody was raised against synthetic 16 amino acid peptide from extracellular domain of human ITGA2 / CD49b. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Dog, Panda, Pig (100%); Bovine, Elephant, Horse, Chicken, Lizard (94%); Opossum, Turkey (88%); Bat, Hamster, Stickleback (81%).
 Antigen Modification    Extracellular Domain
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 Preparation and Storage    Long term: -70 degree C; Short term: +4 degree C
 Other Notes    Small volumes of anti-ITGA2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ITGA2 antibody

   ITGA2 encodes integrin alpha chain 2. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing alpha integrin 2 combines with beta integrin 1 to form a collagen-binding integrin referred to as glycoprotein Ia/IIa when expressed on platelets, and very late (activation) antigen 2 ('VLA-2') when found on T-cells. In addition to adhesion, integrins are known to participate in cell-surface mediated signalling.
 Product Categories/Family for anti-ITGA2 antibody    Family: Integrin
 Applications Tested/Suitable for anti-ITGA2 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-ITGA2 antibody    IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-ITGA2 antibody    Anti-ITGA2 / CD49b antibody IHC of human thymus, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-ITGA2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ITGA2. It may not necessarily be applicable to this product.
 NCBI GI #    116295258
 NCBI GeneID    3673
 NCBI Accession #    NP_002194.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002203.3 [Other Products]
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 UniProt Primary Accession #    P17301 [Other Products]
 UniProt Secondary Accession #    Q14595 [Other Products]
 UniProt Related Accession #    P17301 [Other Products]
 Molecular Weight    129,295 Da
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 NCBI Official Full Name    integrin alpha-2
 NCBI Official Synonym Full Names    integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
 NCBI Official Symbol    ITGA2 [Similar Products]
 NCBI Official Synonym Symbols   
BR; GPIa; CD49B; HPA-5; VLA-2; VLAA2
[Similar Products]
 NCBI Protein Information    integrin alpha-2; collagen receptor; platelet antigen Br; platelet glycoprotein GPIa; VLA2 receptor, alpha-2 subunit; CD49 antigen-like family member B; platelet membrane glycoprotein Ia; human platelet alloantigen system 5; very late activation protein 2 receptor, alpha-2 subunit
 UniProt Protein Name    Integrin alpha-2
 UniProt Synonym Protein Names   
CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD_antigen: CD49b
 Protein Family    Integrin
 UniProt Gene Name    ITGA2 [Similar Products]
 UniProt Synonym Gene Names    CD49B; GPIa [Similar Products]
 UniProt Entry Name    ITA2_HUMAN
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 NCBI Summary for ITGA2    This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
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 UniProt Comments for ITGA2    ITGA2: Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Belongs to the integrin alpha chain family.

Protein type: Cell adhesion; Receptor, misc.; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: focal adhesion; cell surface; perinuclear region of cytoplasm; plasma membrane; nerve terminal; nucleus; integrin complex; external side of plasma membrane

Molecular Function: integrin binding; viral receptor activity; collagen binding; protein binding; protein heterodimerization activity; metal ion binding; laminin binding

Biological Process: axon guidance; entry of virus into host cell; response to muscle activity; extracellular matrix organization and biogenesis; positive regulation of cell adhesion; positive regulation of positive chemotaxis; positive regulation of translation; positive regulation of smooth muscle cell proliferation; positive regulation of leukocyte migration; cell-matrix adhesion; positive regulation of collagen binding; positive regulation of collagen biosynthetic process; positive regulation of cell projection organization and biogenesis; mesodermal cell differentiation; positive regulation of smooth muscle cell migration; response to L-ascorbic acid; response to organic cyclic substance; establishment of protein localization; mammary gland development; positive regulation of smooth muscle contraction; cell adhesion; positive regulation of DNA binding; substrate-bound cell migration; integrin-mediated signaling pathway; response to drug; skin morphogenesis; hypotonic response; cell-substrate adhesion; cellular response to hormone stimulus; cell proliferation; detection of mechanical stimulus involved in sensory perception of pain; organ morphogenesis; response to hypoxia; cell adhesion mediated by integrin; blood coagulation; positive regulation of phagocytosis, engulfment; response to amine stimulus; positive regulation of transmission of nerve impulse; positive regulation of inflammatory response

Disease: Bleeding Disorder, Platelet-type, 9
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 Research Articles on ITGA2    1. Molecular modeling indicated that galactosylation occurred on the periphery of alpha2beta1 integrin interaction with alpha1(IV)382-393 but right in the middle of alpha3beta1 integrin interaction with alpha1(IV)531-543
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ITGA2 antibodyPathways associated with anti-ITGA2 antibody
 Reference Product  PubMed Publications
 ITGB3 antibody  >29 publications with ITGA2 and ITGB3
 ITGB1 antibody  >8 publications with ITGA2 and ITGB1
 COL3A1 antibody  >2 publications with ITGA2 and COL3A1
 LAMA1 antibody  >1 publications with ITGA2 and LAMA1
 FN1 antibody  >1 publications with ITGA2 and FN1
 COL1A2 antibody  >1 publications with ITGA2 and COL1A2
 COL1A1 antibody  >1 publications with ITGA2 and COL1A1
 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 CHL1 Interactions Pathway antibodies  CHL1 Interactions Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
Diseases associated with anti-ITGA2 antibodyOrgans/Tissues associated with anti-ITGA2 antibody
 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >27 publications with ITGA2 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >12 publications with ITGA2 and Nervous System Diseases
 Inflammation Antibodies  >6 publications with ITGA2 and Inflammation
 Hypertension Antibodies  >5 publications with ITGA2 and Hypertension
 Congenital Abnormalities Antibodies  >5 publications with ITGA2 and Congenital Abnormalities
 Fibrosis Antibodies  >4 publications with ITGA2 and Fibrosis
 Myocardial Infarction Antibodies  >4 publications with ITGA2 and Myocardial Infarction
 Kidney Diseases Antibodies  >4 publications with ITGA2 and Kidney Diseases
 Breast Neoplasms Antibodies  >3 publications with ITGA2 and Breast Neoplasms
 Atherosclerosis Antibodies  >3 publications with ITGA2 and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >37 publications with ITGA2 and Blood
 Vascular Antibodies  >8 publications with ITGA2 and Vascular
 Brain Antibodies  >7 publications with ITGA2 and Brain
 Kidney Antibodies  >5 publications with ITGA2 and Kidney
 Placenta Antibodies  >4 publications with ITGA2 and Placenta
 Bone Antibodies  >4 publications with ITGA2 and Bone
 Prostate Antibodies  >3 publications with ITGA2 and Prostate
 Connective Tissue Antibodies  >2 publications with ITGA2 and Connective Tissue
 Uterus Antibodies  >2 publications with ITGA2 and Uterus
 Intestine Antibodies  >2 publications with ITGA2 and Intestine
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