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anti-ITGA3 antibody :: Rabbit ITGA3 / CD49c Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS243261
Unit / Price
0.05 mg  /  $495 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ITGA3 / CD49c, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit Polyclonal to Human ITGA3 / CD49c

 Product Synonym Names    Anti-ITGA3 / CD49c Antibody (Internal) IHC-plus; ITGA3; Alpha3 integrin; CD49c antigen; CD49C; GAPB3; Integrin alpha-3; FRP-2; VCA-2; VLA-3 subunit alpha; VL3A; VLA3a; Galactoprotein B3; GAP-B3; ILNEB; Integrin alpha3; MSK18; Human ITGA3; CD49c
 Product Gene Name   

anti-ITGA3 antibody

[Similar Products]
 Product Synonym Gene Name    CD49c [Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614748
 3D Structure    ModBase 3D Structure for P26006
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Reactivity: Human, Monkey
Predicted Reactivity: Guinea pig, Hamster, Rabbit
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 Specificity    Human ITGA3 / CD49c. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    PBS, less than 0.1% sodium azide.
 Concentration    1 mg/ml (lot specific)
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 Target    ITGA3/CD49c
 Target Species    Human
 Family/Subfamily    Integrin/not assigned-Integrin
 Immunogen Sppecies    ITGA3/CD49c antibody was raised against Human
 Epitope    Internal
 Immunogen Type    Synthetic peptide
 Immunogen    ITGA3 / CD49c antibody was raised against synthetic 18 amino acid peptide from internal region of human ITGA3 / CD49c. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Monkey (100%); Gibbon, Galago, Hamster, Elephant, Rabbit, Guinea pig (94%); Marmoset, Mouse, Rat, Panda, Bovine, Bat, Horse (89%); Pig (83%).
 Antigen Modification    Internal
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 Preparation and Storage    Upon arrival: Aliquot and store undiluted at -20 degree C or below for up to 1 yr. Can be stored undiluted at 4 degree C for up to 1 month. Avoid freeze thaw cycles.
 Other Notes    Small volumes of anti-ITGA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ITGA3 antibody

   ITGA3 encodes the integrin alpha 3 chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 3 undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 to form an integrin that interacts with many extracellular-matrix proteins. The alpha 3 beta 1 integrin is known variously as: very late (activation) antigen 3 (‘VLA-3). Very common antigen 2 (‘VCA-2’), extracellular matrix receptor 1 (‘ECMR1’), and galactoprotein b3 (‘GAPB3’).
 Product Categories/Family for anti-ITGA3 antibody    Family: Integrin
 Applications Tested/Suitable for anti-ITGA3 antibody   

Immunohistochemistry (IHC - Paraffin)

 Application Notes for anti-ITGA3 antibody    IHC-P (2.5 - 5 ug/ml)
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 Immunohistochemistry (IHC) of anti-ITGA3 antibody    Anti-ITGA3 / CD49c antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-ITGA3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ITGA3 antibody    Anti-ITGA3 / CD49c antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
anti-ITGA3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ITGA3. It may not necessarily be applicable to this product.
 NCBI GI #    4504747
 NCBI GeneID    3675
 NCBI Accession #    NP_002195.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_002204.2 [Other Products]
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 UniProt Primary Accession #    P26006 [Other Products]
 UniProt Secondary Accession #    A7E246; B7ZM80; B9EGQ1; D3DTX4; D3DTX5 [Other Products]
 UniProt Related Accession #    P26006 [Other Products]
 Molecular Weight    118,756 Da
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 NCBI Official Full Name    integrin alpha-3 isoform a
 NCBI Official Synonym Full Names    integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
 NCBI Official Symbol    ITGA3 [Similar Products]
 NCBI Official Synonym Symbols   
VL3A; CD49C; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3
[Similar Products]
 NCBI Protein Information    integrin alpha-3; FRP-2; galactoprotein B3; VLA-3 subunit alpha; CD49 antigen-like family member C; antigen identified by monoclonal antibody J143; very late activation protein 3 receptor, alpha-3 subunit
 UniProt Protein Name    Integrin alpha-3
 UniProt Synonym Protein Names   
CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; CD_antigen: CD49cCleaved into the following 2 chains:Integrin alpha-3 heavy chain; Integrin alpha-3 light chain
 Protein Family    Integrin
 UniProt Gene Name    ITGA3 [Similar Products]
 UniProt Synonym Gene Names    MSK18; GAPB3 [Similar Products]
 UniProt Entry Name    ITA3_HUMAN
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 NCBI Summary for ITGA3    The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
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 UniProt Comments for ITGA3    ITGA3: an integral membrane protein that heterodimerizes with a beta chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. Undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1. Two alternatively spliced isoforms have been described.

Protein type: Cell adhesion; Membrane protein, integral; Receptor, misc.; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: filopodium membrane; growth cone; focal adhesion; cell surface; perinuclear region of cytoplasm; basolateral plasma membrane; plasma membrane; excitatory synapse; integrin complex; receptor complex; external side of plasma membrane

Molecular Function: integrin binding; collagen binding; protein domain specific binding; protein binding; protease binding; protein heterodimerization activity; fibronectin binding; metal ion binding; laminin binding; glycoprotein binding

Biological Process: skin development; response to drug; integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; maternal process involved in pregnancy; cell-matrix adhesion; heart development; regulation of BMP signaling pathway; neuron migration; regulation of Wnt receptor signaling pathway; mesodermal cell differentiation; memory; regulation of transforming growth factor beta receptor signaling pathway; negative regulation of Rho protein signal transduction; blood coagulation; leukocyte migration; negative regulation of cell projection organization and biogenesis; lung development

Disease: Interstitial Lung Disease, Nephrotic Syndrome, And Epidermolysis Bullosa, Congenital
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 Research Articles on ITGA3    1. Molecular modeling indicated that galactosylation occurred on the periphery of alpha2beta1 integrin interaction with alpha1(IV)382-393 but right in the middle of alpha3beta1 integrin interaction with alpha1(IV)531-543
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ITGA3 antibodyPathways associated with anti-ITGA3 antibody
 Reference Product  PubMed Publications
 ITGB4 antibody  >8 publications with ITGA3 and ITGB4
 ITGB1 antibody  >8 publications with ITGA3 and ITGB1
 ITGB5 antibody  >4 publications with ITGA3 and ITGB5
 LAMA5 antibody  >2 publications with ITGA3 and LAMA5
 FN1 antibody  >2 publications with ITGA3 and FN1
 LAMB3 antibody  >1 publications with ITGA3 and LAMB3
 VTN antibody  >1 publications with ITGA3 and VTN
 LAMA3 antibody  >1 publications with ITGA3 and LAMA3
 RELN antibody  >1 publications with ITGA3 and RELN
 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
Diseases associated with anti-ITGA3 antibodyOrgans/Tissues associated with anti-ITGA3 antibody
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >4 publications with ITGA3 and Lung Neoplasms
 Kidney Diseases Antibodies  >4 publications with ITGA3 and Kidney Diseases
 Lung Diseases Antibodies  >4 publications with ITGA3 and Lung Diseases
 Nervous System Diseases Antibodies  >3 publications with ITGA3 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >3 publications with ITGA3 and Congenital Abnormalities
 Nervous System Malformations Antibodies  >3 publications with ITGA3 and Nervous System Malformations
 Breast Neoplasms Antibodies  >3 publications with ITGA3 and Breast Neoplasms
 Neural Tube Defects Antibodies  >2 publications with ITGA3 and Neural Tube Defects
 Cell Transformation, Neoplastic Antibodies  >2 publications with ITGA3 and Cell Transformation, Neoplastic
 Disease Models, Animal Antibodies  >1 publications with ITGA3 and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >6 publications with ITGA3 and Lung
 Kidney Antibodies  >6 publications with ITGA3 and Kidney
 Embryonic Tissue Antibodies  >5 publications with ITGA3 and Embryonic Tissue
 Blood Antibodies  >5 publications with ITGA3 and Blood
 Skin Antibodies  >4 publications with ITGA3 and Skin
 Lymph Node Antibodies  >4 publications with ITGA3 and Lymph Node
 Nerve Antibodies  >3 publications with ITGA3 and Nerve
 Bone Antibodies  >3 publications with ITGA3 and Bone
 Brain Antibodies  >3 publications with ITGA3 and Brain
 Mouth Antibodies  >3 publications with ITGA3 and Mouth
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