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anti-ITGA6 antibody :: Rabbit anti-Human, Mouse ITGA6 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS9403415
Immunohistochemistry (IHC)
Unit / Price
0.1 mL  /  $255 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ITGA6, Polyclonal Antibody

★Popular Item★
 Also Known As   

ITGA6 Antibody

 Product Synonym Names    CD49f; VLA-6; ITGA6B
 Product Gene Name   

anti-ITGA6 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147556
 3D Structure    ModBase 3D Structure for P23229
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Human, Mouse
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 Specificity    The antibody detects endogenous levels of total ITGA6 protein.
 Purity/Purification    Antigen affinity purification.
 Form/Format    Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
 Concentration    1.7 mg/ml (lot specific)
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 Immunogen Type    Peptide
 Immunogen Description    Synthetic peptide corresponding to a region derived from internal residues of human integrin, alpha 6
 Target Name    ITGA6
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 Preparation and Storage    Store at -20 degree C
 Other Notes    Small volumes of anti-ITGA6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ITGA6 antibody

   The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.
 Product Categories/Family for anti-ITGA6 antibody    Total protein Ab
 Applications Tested/Suitable for anti-ITGA6 antibody   

Immunohistochemistry (IHC)

 Application Notes for anti-ITGA6 antibody    Immunohistochemistry: 1:25-1:100
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 Immunohistochemistry (IHC) of anti-ITGA6 antibody    Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue using at dilution 1/50.
anti-ITGA6 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ITGA6. It may not necessarily be applicable to this product.
 NCBI GI #    119395742
 NCBI GeneID    3655
 NCBI Accession #    NP_000201.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000210.2 [Other Products]
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 UniProt Primary Accession #    P23229 [Other Products]
 UniProt Secondary Accession #    Q08443; Q0MRC7; Q14646; Q16508; Q53RX7; Q59HB7; B2RMU9; B4DG69; B4DKB8; C4AM96; G5E9H1 [Other Products]
 UniProt Related Accession #    P23229 [Other Products]
 Molecular Weight    122,358 Da
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 NCBI Official Full Name    integrin alpha-6 isoform b
 NCBI Official Synonym Full Names    integrin, alpha 6
 NCBI Official Symbol    ITGA6 [Similar Products]
 NCBI Official Synonym Symbols   
CD49f; VLA-6; ITGA6B
[Similar Products]
 NCBI Protein Information    integrin alpha-6
 UniProt Protein Name    Integrin alpha-6
 UniProt Synonym Protein Names   
CD49 antigen-like family member F; VLA-6; CD_antigen: CD49f
 Protein Family    Integrin
 UniProt Gene Name    ITGA6 [Similar Products]
 UniProt Synonym Gene Names    Alpha6p [Similar Products]
 UniProt Entry Name    ITA6_HUMAN
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 NCBI Summary for ITGA6    The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ITGA6    ITGA6: Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome. Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-6 associates with either beta-1 or beta-4. Interacts with HPS5. Interacts with RAB21. Integrin alpha-6/beta-4 is predominantly expressed by epithelia. Isoforms containing segment X1 are ubiquitously expressed. Isoforms containing segment X1X2 are expressed in heart, kidney, placenta, colon, duodenum, myoblasts and myotubes, and in a limited number of cell lines; they are always coexpressed with the ubiquitous isoform containing segment X1. In some tissues (e.g. Salivary gland), isoforms containing cytoplasmic segment A and isoforms containing segment B are detected while in others, only isoforms containing one cytoplasmic segment are found (segment A in epidermis and segment B in kidney). Belongs to the integrin alpha chain family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 2q31.1

Cellular Component: cell surface; cell-cell adherens junction; focal adhesion; hemidesmosome; basal plasma membrane; plasma membrane; basement membrane; filopodium; external side of plasma membrane

Molecular Function: integrin binding; protein binding; metal ion binding; laminin binding

Biological Process: skin development; integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; filopodium formation; positive regulation of apoptosis; cell-matrix adhesion; cell-substrate adhesion; hemidesmosome assembly; cell-cell adhesion; gut development; positive regulation of cell-cell adhesion; cell-substrate junction assembly; brown fat cell differentiation; cellular response to extracellular stimulus; cell adhesion mediated by integrin; positive regulation of transcription from RNA polymerase II promoter; blood coagulation; leukocyte migration; positive regulation of phosphorylation

Disease: Epidermolysis Bullosa Junctionalis With Pyloric Atresia
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 Research Articles on ITGA6    1. our observations suggest that miR-25 is a key regulator of invasiveness in human prostate cancer through its direct interactions with av- and a6-integrin expression
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ITGA6 antibodyPathways associated with anti-ITGA6 antibody
 Reference Product  PubMed Publications
 ITGB4 antibody  >22 publications with ITGA6 and ITGB4
 ITGB1 antibody  >14 publications with ITGA6 and ITGB1
 ITGB5 antibody  >5 publications with ITGA6 and ITGB5
 CD9 antibody  >3 publications with ITGA6 and CD9
 LAMA5 antibody  >1 publications with ITGA6 and LAMA5
 COL17A1 antibody  >1 publications with ITGA6 and COL17A1
 PLEC antibody  >1 publications with ITGA6 and PLEC
 Products by Pathway  Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway antibodies  Assembly Of Collagen Fibrils And Other Multimeric Structures Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
Diseases associated with anti-ITGA6 antibodyOrgans/Tissues associated with anti-ITGA6 antibody
 Disease Name  Pubmed Publications
 Epidermolysis bullosa with pyloric atresia Antibodies  >11 publications with ITGA6 and Epidermolysis bullosa with pyloric atresia
 Breast Neoplasms Antibodies  >10 publications with ITGA6 and Breast Neoplasms
 Neoplasm Metastasis Antibodies  >8 publications with ITGA6 and Neoplasm Metastasis
 Prostatic Diseases Antibodies  >6 publications with ITGA6 and Prostatic Diseases
 Fibrosis Antibodies  >5 publications with ITGA6 and Fibrosis
 Prostatic Neoplasms Antibodies  >5 publications with ITGA6 and Prostatic Neoplasms
 Inflammation Antibodies  >5 publications with ITGA6 and Inflammation
 Neoplasm Invasiveness Antibodies  >4 publications with ITGA6 and Neoplasm Invasiveness
 Liver Neoplasms Antibodies  >3 publications with ITGA6 and Liver Neoplasms
 Skin Neoplasms Antibodies  >3 publications with ITGA6 and Skin Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >23 publications with ITGA6 and Skin
 Blood Antibodies  >12 publications with ITGA6 and Blood
 Testis Antibodies  >12 publications with ITGA6 and Testis
 Stomach Antibodies  >11 publications with ITGA6 and Stomach
 Prostate Antibodies  >11 publications with ITGA6 and Prostate
 Bone Antibodies  >8 publications with ITGA6 and Bone
 Nerve Antibodies  >5 publications with ITGA6 and Nerve
 Vascular Antibodies  >5 publications with ITGA6 and Vascular
 Liver Antibodies  >5 publications with ITGA6 and Liver
 Brain Antibodies  >5 publications with ITGA6 and Brain
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