NP_001107852.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
119,224 Da
NCBI Official Full Name
integrin alpha-L isoform b
NCBI Official Synonym Full Names
integrin subunit alpha L
NCBI Protein Information
integrin alpha-L
UniProt Protein Name
Integrin alpha-L
UniProt Synonym Protein Names
CD11 antigen-like family member A; Leukocyte adhesion glycoprotein LFA-1 alpha chain; LFA-1A; Leukocyte function-associated molecule 1 alpha chain; CD_antigen: CD11a
UniProt Synonym Gene Names
UniProt Entry Name
ITAL_HUMAN
NCBI Summary for ITGAL
ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Comments for ITGAL
ITGAL: Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes. Belongs to the integrin alpha chain family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Motility/polarity/chemotaxis; Membrane protein, integral; Cell adhesion; Cell surface
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: cell surface; external side of plasma membrane; immunological synapse; integrin complex; intercellular junction; membrane; plasma membrane
Molecular Function: cell adhesion molecule binding; ICAM-3 receptor activity; metal ion binding; protein binding; protein complex binding; protein heterodimerization activity
Biological Process: activated T cell proliferation; blood coagulation; cell adhesion; cell motility; cell-matrix adhesion; extracellular matrix organization and biogenesis; heterophilic cell adhesion; inflammatory response; integrin-mediated signaling pathway; leukocyte adhesion; leukocyte migration; positive regulation of calcium-mediated signaling; positive regulation of T cell proliferation; receptor clustering; regulation of immune response; signal transduction; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
Research Articles on ITGAL
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Products associated with anti-ITGAL antibody
Pathways associated with anti-ITGAL antibody
Diseases associated with anti-ITGAL antibody
Organs/Tissues associated with anti-ITGAL antibody
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