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anti-ITGAM antibody :: Rabbit ITGAM Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS128062
Western Blot (WB)
Unit / Price
0.05 mL  /  $230 +1 FREE 8GB USB
0.1 mL  /  $305 +1 FREE 8GB USB
0.2 mL  /  $460 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ITGAM, Polyclonal Antibody

★Popular Item★
 Also Known As   

ITGAM Polyclonal Antibody

 Product Synonym Names    CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
 Product Gene Name   

anti-ITGAM antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 609939
 3D Structure    ModBase 3D Structure for P11215
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Affinity Purification
 Concentration    1mg/ml (lot specific)
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 Species    Human
 Immunogen    Recombinant Protein
 Immunogen    Recombinant protein of human ITGAM
 Calculated Molecular Weight    127kDa
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 Preparation and Storage    Store at -20 degree C (regular) or -80 degree C (long term). Avoid freeze / thaw cycles.
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Other Notes    Small volumes of anti-ITGAM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ITGAM antibody

   ITGAM, also named as CD11B and CR3A, belongs to the integrin alpha chain family. It is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. ITGAM is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. It is also a receptor for fibrinogen, factor X and ICAM1. ITGAM recognizes P1 and P2 peptides of fibrinogen gamma chain.
 Product Categories/Family for anti-ITGAM antibody    Polyclonal
 Applications Tested/Suitable for anti-ITGAM antibody   

Western Blot (WB), Immunohistochemistry (IHC)

 Application Notes for anti-ITGAM antibody    WB: 1:500 - 1:2000
IHC: 1:50 - 1:200
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 Western Blot (WB) of anti-ITGAM antibody    Western blot analysis of extracts of various cell lines, using ITGAM antibody at 1:1000 dilution.
Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (MBS128200) at 1:10000 dilution.
Lysates/proteins: 25ug per lane.
Blocking buffer: 3% nonfat dry milk in TBST.
anti-ITGAM antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ITGAM. It may not necessarily be applicable to this product.
 NCBI GI #    1708572
 NCBI GeneID    3684
 NCBI Accession #    P11215.2 [Other Products]
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 UniProt Primary Accession #    P11215 [Other Products]
 UniProt Secondary Accession #    Q4VAK0; Q4VAK1; Q4VAK2 [Other Products]
 UniProt Related Accession #    P11215 [Other Products]
 Molecular Weight    1152
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 NCBI Official Full Name    Integrin alpha-M
 NCBI Official Synonym Full Names    integrin, alpha M (complement component 3 receptor 3 subunit)
 NCBI Official Symbol    ITGAM [Similar Products]
 NCBI Official Synonym Symbols   
CR3A; MO1A; CD11B; MAC-1; MAC1A; SLEB6
[Similar Products]
 NCBI Protein Information    integrin alpha-M; CR-3 alpha chain; antigen CD11b (p170); leukocyte adhesion receptor MO1; CD11 antigen-like family member B; macrophage antigen alpha polypeptide; cell surface glycoprotein MAC-1 subunit alpha; neutrophil adherence receptor alpha-M subunit
 UniProt Protein Name    Integrin alpha-M
 UniProt Synonym Protein Names   
CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; CD_antigen: CD11b
 Protein Family    Integrin
 UniProt Gene Name    ITGAM [Similar Products]
 UniProt Synonym Gene Names    CD11B; CR3A [Similar Products]
 UniProt Entry Name    ITAM_HUMAN
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 NCBI Summary for ITGAM    This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
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 UniProt Comments for ITGAM    ITGAM: a single-pass type I membrane protein of the integrin alpha chain family. Implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. Also known as CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the RGD peptide in C3b. A receptor for fibrinogen, factor X and ICAM1. Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Predominantly expressed in monocytes and granulocytes.

Protein type: Cell adhesion; Motility/polarity/chemotaxis; Membrane protein, integral

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cell surface; plasma membrane; integrin complex; nucleus; external side of plasma membrane

Molecular Function: heparan sulfate proteoglycan binding; heparin binding; protein binding; opsonin binding; protein heterodimerization activity; metal ion binding; glycoprotein binding

Biological Process: integrin-mediated signaling pathway; neutrophil chemotaxis; extracellular matrix organization and biogenesis; microglia development; activated T cell proliferation; leukocyte migration during inflammatory response; cellular extravasation; toll-like receptor signaling pathway; innate immune response; cell adhesion; blood coagulation; leukocyte migration; toll-like receptor 4 signaling pathway

Disease: Systemic Lupus Erythematosus, Susceptibility To, 6
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 Research Articles on ITGAM    1. hnRNP K in PU.1-containing complexes recruited at the CD11b promoter: a distinct role in modulating granulocytic and monocytic differentiation of AML-derived cells.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ITGAM antibodyPathways associated with anti-ITGAM antibody
 Reference Product  PubMed Publications
 ITGB2 antibody  >1645 publications with ITGAM and ITGB2
 ICAM1 antibody  >440 publications with ITGAM and ICAM1
 ICAM2 antibody  >19 publications with ITGAM and ICAM2
 PLAUR antibody  >15 publications with ITGAM and PLAUR
 THY1 antibody  >15 publications with ITGAM and THY1
 ICAM4 antibody  >6 publications with ITGAM and ICAM4
 SELP antibody  >6 publications with ITGAM and SELP
 JAM3 antibody  >5 publications with ITGAM and JAM3
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
Diseases associated with anti-ITGAM antibodyOrgans/Tissues associated with anti-ITGAM antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1407 publications with ITGAM and Inflammation
 Disease Models, Animal Antibodies  >825 publications with ITGAM and Disease Models, Animal
 Necrosis Antibodies  >822 publications with ITGAM and Necrosis
 Nervous System Diseases Antibodies  >633 publications with ITGAM and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >502 publications with ITGAM and Cardiovascular Diseases
 Brain Diseases Antibodies  >430 publications with ITGAM and Brain Diseases
 Neoplasms, Experimental Antibodies  >179 publications with ITGAM and Neoplasms, Experimental
 Heart Diseases Antibodies  >157 publications with ITGAM and Heart Diseases
 Pain Antibodies  >125 publications with ITGAM and Pain
 Atherosclerosis Antibodies  >122 publications with ITGAM and Atherosclerosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4485 publications with ITGAM and Blood
 Bone Antibodies  >844 publications with ITGAM and Bone
 Bone Marrow Antibodies  >785 publications with ITGAM and Bone Marrow
 Brain Antibodies  >628 publications with ITGAM and Brain
 Lung Antibodies  >536 publications with ITGAM and Lung
 Spleen Antibodies  >513 publications with ITGAM and Spleen
 Lymph Node Antibodies  >309 publications with ITGAM and Lymph Node
 Nerve Antibodies  >243 publications with ITGAM and Nerve
 Intestine Antibodies  >156 publications with ITGAM and Intestine
 Kidney Antibodies  >141 publications with ITGAM and Kidney
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