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anti-ITIH4 antibody :: Goat ITIH4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS421694
Immunohistochemistry (IHC)
Unit / Price
0.1 mg  /  $300 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ITIH4, Polyclonal Antibody

 Also Known As   

Goat anti-ITIH4 Antibody

 Product Synonym Names    Goat Anti-ITIH4 (aa890-903) Antibody; ITIH4; inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein); DKFZp686G21125; H4P; IHRP; ITIHL1; PK120; inter-alpha (globulin) inhibitor H4; plasma kallikrein-sensitive glycoprotein; ITIH4 antibody; inter-alpha (globulin) inhibitor H4 (plasma Kallikrein-sensitive glycoprotein) antibody; DKFZp686G21125 antibody; H4P antibody; IHRP antibody; ITIHL1 antibody; PK120 antibody; inter-alpha (globulin) inhibitor H4 antibody; plasma kallikrein-sensitive glycoprotein antibody
 Product Gene Name   

anti-ITIH4 antibody

[Similar Products]
 Antibody/Peptide Pairs    ITIH4 peptide (MBS428237) is used for blocking the activity of ITIH4 antibody (MBS421694)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    ERLCVDPRHR QGPVN
 OMIM    600564
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Tested: Human; Expected from sequence similarity: Human
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 Purity/Purification    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
 Form/Format    Supplied at 0.5 mg/ml in Tris saline, 0. 02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
 Concentration    100ug specific antibody in 200ul (lot specific)
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 Immunogen    Peptide with sequence ERLCVDPRHRQGPVN, from the internal region of the protein sequence according to NP_002209.2.
 Epitope    Internal region
 Note    The immunizing peptide represents a region of the 35kDa chain. This chain is glycosylated giving rise to an apparent higher molecular weight.
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 Preparation and Storage    Aliquot and store at -20 degree C. Minimize freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2015 Certified Laboratory.
 Other Notes    Small volumes of anti-ITIH4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ITIH4 antibody   

Peptide ELISA (EIA), Immunohistochemistry (IHC)

 Application Notes for anti-ITIH4 antibody    Peptide ELISA: Antibody detection limit dilution 1: 16000.
Immunohistochemistry: In paraffin embedded Human Liver shows vesicular staining in the cytoplasm of hepatocytes. Recommended concentration, 4-6ug/ml.
Western Blot: Preliminary experiments gave an approx.150kDa band in Human Liver and Lung lysates after 0. 03ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 103kDa according to NP_002209.2. The 150kDa band was successfully blocked by incubation with the immunizing peptide.
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 Immunohistochemistry (IHC) of anti-ITIH4 antibody    (3.8ug/ml) staining of paraffin embedded Human Liver. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
anti-ITIH4 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ITIH4. It may not necessarily be applicable to this product.
 NCBI GI #    31542984
 NCBI GeneID    3700
 NCBI Accession #    NP_002209.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002218.4 [Other Products]
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 UniProt Secondary Accession #    Q15135; Q9P190; Q9UQ54; B7Z545; E9PGN5 [Other Products]
 UniProt Related Accession #    Q14624 [Other Products]
 Molecular Weight    93,852 Da
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 NCBI Official Full Name    inter-alpha-trypsin inhibitor heavy chain H4 isoform 1
 NCBI Official Synonym Full Names    inter-alpha-trypsin inhibitor heavy chain family member 4
 NCBI Official Symbol    ITIH4 [Similar Products]
 NCBI Official Synonym Symbols   
H4P; IHRP; GP120; PK120; ITIHL1; PK-120; ITI-HC4
[Similar Products]
 NCBI Protein Information    inter-alpha-trypsin inhibitor heavy chain H4
 UniProt Protein Name    Inter-alpha-trypsin inhibitor heavy chain H4
 UniProt Synonym Protein Names   
Inter-alpha-trypsin inhibitor family heavy chain-related protein; IHRP
 Protein Family    Inter alpha-trypsin inhibitor
 UniProt Gene Name    ITIH4 [Similar Products]
 UniProt Synonym Gene Names    IHRP; ITIHL1; PK120; ITI heavy chain H4; ITI-HC4; Inter-alpha-inhibitor heavy chain 4; IHRP; Gp120; PK-120 [Similar Products]
 UniProt Entry Name    ITIH4_HUMAN
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 NCBI Summary for ITIH4    The protein encoded by this gene is secreted into the blood, where it is cleaved by plasma kallikrein into two smaller forms. Expression of this gene has been detected only in liver, and it seems to be upregulated during surgical trauma. This gene is part of a cluster of similar genes on chromosome 3. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
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 UniProt Comments for ITIH4    ITIH4: May be involved in acute phase reactions. Belongs to the ITIH family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3p21.1

Cellular Component: extracellular region; plasma membrane

Molecular Function: endopeptidase inhibitor activity; protein binding; serine-type endopeptidase inhibitor activity

Biological Process: acute-phase response; hyaluronan metabolic process; platelet degranulation; response to cytokine stimulus

Disease: Hypercholesterolemia, Familial
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 Research Articles on ITIH4    1. ITIH4 peptide isoform as a preterm birth biomarker and its associated SNP implications
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-ITIH4 antibodyDiseases associated with anti-ITIH4 antibody
 Products by Pathway  Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Platelet Activation, Signaling And Aggregation Pathway antibodies  Platelet Activation, Signaling And Aggregation Pathway Diagram
 Platelet Degranulation Pathway antibodies  Platelet Degranulation Pathway Diagram
 Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies  Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >14 publications with ITIH4 and Inflammation
 Liver Diseases Antibodies  >7 publications with ITIH4 and Liver Diseases
 Fibrosis Antibodies  >5 publications with ITIH4 and Fibrosis
 Brain Diseases Antibodies  >5 publications with ITIH4 and Brain Diseases
 Carcinoma, Hepatocellular Antibodies  >4 publications with ITIH4 and Carcinoma, Hepatocellular
 Lung Diseases Antibodies  >4 publications with ITIH4 and Lung Diseases
 Liver Neoplasms Antibodies  >4 publications with ITIH4 and Liver Neoplasms
 Colonic Neoplasms Antibodies  >4 publications with ITIH4 and Colonic Neoplasms
 Cardiovascular Diseases Antibodies  >3 publications with ITIH4 and Cardiovascular Diseases
 Hypertension Antibodies  >3 publications with ITIH4 and Hypertension
Organs/Tissues associated with anti-ITIH4 antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >69 publications with ITIH4 and Blood
 Liver Antibodies  >20 publications with ITIH4 and Liver
 Lung Antibodies  >5 publications with ITIH4 and Lung
 Prostate Antibodies  >4 publications with ITIH4 and Prostate
 Brain Antibodies  >4 publications with ITIH4 and Brain
 Pancreas Antibodies  >3 publications with ITIH4 and Pancreas
 Connective Tissue Antibodies  >3 publications with ITIH4 and Connective Tissue
 Ovary Antibodies  >1 publications with ITIH4 and Ovary
 Placenta Antibodies  >1 publications with ITIH4 and Placenta
 Embryonic Tissue Antibodies  >1 publications with ITIH4 and Embryonic Tissue
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