NP_079470.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
inositol-trisphosphate 3-kinase C
NCBI Official Synonym Full Names
inositol-trisphosphate 3-kinase C
NCBI Protein Information
inositol-trisphosphate 3-kinase C; IP3K C; IP3 3-kinase C; InsP 3 kinase C; insP 3-kinase C; inositol 1,4,5-trisphosphate 3-kinase C
UniProt Protein Name
Inositol-trisphosphate 3-kinase C
UniProt Synonym Protein Names
Inositol 1,4,5-trisphosphate 3-kinase C
UniProt Synonym Gene Names
UniProt Entry Name
IP3KC_HUMAN
NCBI Summary for ITPKC
This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate. The encoded protein is localized to the nucleus and cytoplasm and has both nuclear import and nuclear export activity. Single nucleotide polymorphisms in this gene are associated with Kawasaki disease.[provided by RefSeq, Sep 2009]
UniProt Comments for ITPKC
Function: Can phosphorylate inositol 2,4,5-triphosphate to inositol 2,4,5,6-tetraphosphate
By similarity.
Catalytic activity: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate.
Enzyme regulation: Activated by calcium/calmodulin. Inhibited by high concentrations of the substrate Ins(1,2,4)P3, and allosterically activated by the product Ins(1,3,4,5)P4. Ref.1
Subcellular location: Nucleus. Cytoplasm. Note: Shuttles actively between nucleus and cytoplasm with both nuclear import and nuclear export activity. Ref.5
Tissue specificity: Highly expressed in pancreas, skeletal muscle, liver, placenta and weakly in kidney and brain. Ref.1
Involvement in disease: Kawasaki disease (KWD) [MIM:611775]: An acute, self-limited vasculitis of infants and children characterized by prolonged fever unresponsive to antibiotics, polymorphous skin rash, erythema of the oral mucosa, lips, and tongue, erythema of the palms and soles, bilateral conjunctival injection, and cervical lymphadenopathy.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.7
Sequence similarities: Belongs to the inositol phosphokinase (IPK) family.
Research Articles on ITPKC
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Pathways associated with anti-ITPKC antibody
Products by Pathway |
Pathway Diagram |
1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies |
1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram |
1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway antibodies |
1D-myo-inositol Hexakisphosphate Biosynthesis II (mammalian) Pathway Diagram |
Calcium Signaling Pathway antibodies |
Calcium Signaling Pathway Diagram |
Calcium Signaling Pathway antibodies |
Calcium Signaling Pathway Diagram |
D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies |
D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram |
D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway antibodies |
D-myo-inositol (1,3,4)-trisphosphate Biosynthesis Pathway Diagram |
Inositol Phosphate Metabolism Pathway antibodies |
Inositol Phosphate Metabolism Pathway Diagram |
Inositol Phosphate Metabolism Pathway antibodies |
Inositol Phosphate Metabolism Pathway Diagram |
Inositol Phosphate Metabolism Pathway antibodies |
Inositol Phosphate Metabolism Pathway Diagram |
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway antibodies |
Inositol Phosphate Metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4 Pathway Diagram |
Diseases associated with anti-ITPKC antibody
Organs/Tissues associated with anti-ITPKC antibody
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