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anti-ITPR2 antibody :: Goat ITPR2 / IP3 Receptor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS242553
Unit / Price
0.05 mg  /  $530 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

ITPR2 / IP3 Receptor, Polyclonal Antibody

 Also Known As   

Goat Polyclonal to Human ITPR2 / IP3 Receptor

 Product Synonym Names    Anti-ITPR2 / IP3 Receptor Antibody (Internal) IHC-plus; ITPR2; IP3R 2; InsP3R2; IP3R2; InsP3R type II; IP3 receptor; InsP3R type 2; IP3 receptor isoform 2; Type 2 InsP3 receptor; Human ITPR2; IP3 Receptor
 Product Gene Name   

anti-ITPR2 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    600144
 3D Structure    ModBase 3D Structure for Q14571
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 Clonality    Polyclonal
 Host    Goat
 Species Reactivity    Gibbon, Gorilla, Human, Monkey
Predicted Reactivity: Bat, Bovine, Dog, Horse, Pig, Rabbit (at least 90% immunogen sequence identity)
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 Specificity    Human ITPR2. No cross-reactivity expected with other types of ITPR.
 Purity/Purification    Immunoaffinity Purified
 Form/Format    Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
 Concentration    0.5 mg/ml (lot specific)
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 Target Species    Human
 Immunogen Description    Synthetic peptide C-PIEESNILSPVQD from an internal region of human ITPR2 (NP_002214.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Panda, Bat, Dog, Bovine, Rabbit, Horse, Pig, Opossum (92%); Turkey, Chicken (85%).
 Immunogen Type    Synthetic peptide
 Immunogen    ITPR2 / IP3 Receptor antibody was raised against synthetic peptide C-PIEESNILSPVQD from an internal region of human ITPR2 (NP_002214.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Monkey (100%); Panda, Bat, Dog, Bovine, Rabbit, Horse, Pig, Opossum (92%); Turkey, Chicken (85%).
 Antigen Modification    Internal
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 Preparation and Storage    Store at -20 degree C. Minimize freezing and thawing.
 Other Notes    Small volumes of anti-ITPR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ITPR2 antibody    Family: Ion Channel
Subfamily: Inositol 1,4,5-triphosphate receptor
 Applications Tested/Suitable for anti-ITPR2 antibody   

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

 Application Notes for anti-ITPR2 antibody    ELISA (1:128000), IHC-P (3.75 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...
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 Immunohistochemistry (IHC) of anti-ITPR2 antibody    Anti-ITPR2 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml.
anti-ITPR2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ITPR2 antibody    Anti-ITPR2 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml.
anti-ITPR2 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ITPR2 antibody    Anti-ITPR2 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 75 ug/ml.
anti-ITPR2 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ITPR2. It may not necessarily be applicable to this product.
 NCBI GI #    95147335
 NCBI GeneID    3709
 NCBI Accession #    NP_002214.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002223.2 [Other Products]
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 UniProt Primary Accession #    Q14571 [Other Products]
 UniProt Secondary Accession #    O94773 [Other Products]
 UniProt Related Accession #    Q14571 [Other Products]
 Molecular Weight    20,608 Da
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 NCBI Official Full Name    inositol 1,4,5-trisphosphate receptor type 2
 NCBI Official Synonym Full Names    inositol 1,4,5-trisphosphate receptor, type 2
 NCBI Official Symbol    ITPR2 [Similar Products]
 NCBI Official Synonym Symbols   
IP3R2; CFAP48
[Similar Products]
 NCBI Protein Information    inositol 1,4,5-trisphosphate receptor type 2; IP3R 2; insP3R2; IP3 receptor; type 2 InsP3 receptor; cilia and flagella associated protein 48; inositol 1,4,5-triphosphate receptor, type 2; type 2 inositol 1,4,5-trisphosphate receptor
 UniProt Protein Name    Inositol 1,4,5-trisphosphate receptor type 2
 UniProt Synonym Protein Names   
IP3 receptor isoform 2; IP3R 2; InsP3R2; Type 2 inositol 1,4,5-trisphosphate receptor; Type 2 InsP3 receptor
 Protein Family    Inositol 1,4,5-trisphosphate receptor
 UniProt Gene Name    ITPR2 [Similar Products]
 UniProt Synonym Gene Names    IP3R 2; InsP3R2; Type 2 InsP3 receptor [Similar Products]
 UniProt Entry Name    ITPR2_HUMAN
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 NCBI Summary for ITPR2    The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
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 UniProt Comments for ITPR2    IP3R2: a multi-pass endoplasmic reticulum membrane receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA. Most normal tissues displayed weak to moderate cytoplasmic positivity. Strong staining was observed in the gastrointestinal tract, hepatocytes and exocrine pancreas. Short isoform Is found in skeletal muscle and heart. The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. Phosphorylation by PKA increases calcium release. Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor. Belongs to the InsP3 receptor family. 2 isoforms of the human protein are produced by alternative splicing. The short isoform is found in skeletal muscle and heart.

Protein type: Membrane protein, multi-pass; Channel, calcium; Membrane protein, integral; Channel, ligand-gated

Chromosomal Location of Human Ortholog: 12p11

Cellular Component: endoplasmic reticulum membrane; sarcoplasmic reticulum membrane; membrane; plasma membrane; integral to membrane; cell cortex; receptor complex

Molecular Function: calcium ion transmembrane transporter activity; phosphoinositide binding; inositol 1,4,5-triphosphate-sensitive calcium-release channel activity

Biological Process: epidermal growth factor receptor signaling pathway; platelet activation; inositol phosphate-mediated signaling; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; signal transduction; transport; phospholipase C activation; response to hypoxia; energy reserve metabolic process; innate immune response; blood coagulation; vascular endothelial growth factor receptor signaling pathway; regulation of insulin secretion

Disease: Anhidrosis, Isolated, With Normal Sweat Glands
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 Research Articles on ITPR2    1. ITPR2 and hypertrophy specific gene expression is regulated, in part, by a positive feedback regulation between InsP3R2 and calcineurin-NFATc signaling pathways.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ITPR2 antibodyPathways associated with anti-ITPR2 antibody
 Reference Product  PubMed Publications
 PLCD1 antibody  >1 publications with ITPR2 and PLCD1
 PLCE1 antibody  >1 publications with ITPR2 and PLCE1
 CALM1 antibody  >1 publications with ITPR2 and CALM1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimer's Disease Pathway antibodies  Alzheimer's Disease Pathway Diagram
 Alzheimers Disease Pathway antibodies  Alzheimers Disease Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Ca2+ Pathway antibodies  Ca2+ Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
Diseases associated with anti-ITPR2 antibodyOrgans/Tissues associated with anti-ITPR2 antibody
 Disease Name  Pubmed Publications
 Lung Diseases Antibodies  >4 publications with ITPR2 and Lung Diseases
 Inflammation Antibodies  >4 publications with ITPR2 and Inflammation
 Hypertension Antibodies  >3 publications with ITPR2 and Hypertension
 Kidney Diseases Antibodies  >3 publications with ITPR2 and Kidney Diseases
 Liver Diseases Antibodies  >2 publications with ITPR2 and Liver Diseases
 Hypertrophy Antibodies  >2 publications with ITPR2 and Hypertrophy
 Disease Models, Animal Antibodies  >2 publications with ITPR2 and Disease Models, Animal
 Cell Transformation, Neoplastic Antibodies  >1 publications with ITPR2 and Cell Transformation, Neoplastic
 Asthma Antibodies  >1 publications with ITPR2 and Asthma
 Lung Neoplasms Antibodies  >1 publications with ITPR2 and Lung Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >12 publications with ITPR2 and Brain
 Blood Antibodies  >10 publications with ITPR2 and Blood
 Heart Antibodies  >8 publications with ITPR2 and Heart
 Muscle Antibodies  >7 publications with ITPR2 and Muscle
 Kidney Antibodies  >5 publications with ITPR2 and Kidney
 Lung Antibodies  >4 publications with ITPR2 and Lung
 Vascular Antibodies  >3 publications with ITPR2 and Vascular
 Nerve Antibodies  >3 publications with ITPR2 and Nerve
 Liver Antibodies  >3 publications with ITPR2 and Liver
 Connective Tissue Antibodies  >2 publications with ITPR2 and Connective Tissue
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