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anti-IgG antibody :: Rabbit IgG receptor FcRn large subunit p51 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1488262
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IgG receptor FcRn large subunit p51, Polyclonal Antibody

★Popular Item★
 Also Known As   

Rabbit anti-human IgG receptor FcRn large subunit p51 polyclonal Antibody

 Product Synonym Names    IgG Fc fragment receptor transporter alpha chain FCGRT FCRN
 Product Gene Name   

anti-IgG antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    601437
 3D Structure    ModBase 3D Structure for P55899
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse. Other species are not tested. Please decide the specificity by homology
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    Non-conjugated
 Immunogen    Recombinant human IgG receptor FcRn large subunit p51 protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-46328 / sc-46326 / sc-46330 / sc-46329 / sc-66893 / sc-66892
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-IgG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IgG antibody   

ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC)

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 Western Blot (WB) of anti-IgG antibody    Western blot
All lanes: IgG receptor FcRn large subunit p51 antibody at 2ug/ml
Lane 1:HepG2 whole cell lysate
Lane 2:mouse liver tissue
Lane 3:mouse spleen tissue
Lane 4:A549 whole cell lysate
Secondary
Goat polyclonal to rabbit at 1/10000 dilution
Predicted band size: 40kDa
Observed band size: 40kDa

anti-IgG antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-IgG antibody    Western blot
All lanes: FCGRT antibody at 5.3 ug/ml
Lane 1: Mouse liver tissue
Lane 2: Mouse kidney tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 39 kDa
Observed band size: 39 kDa

anti-IgG antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-IgG antibody    Immunohistochemistry of paraffin-embedded human placenta tissue using MBS1488262 at dilution 1:100
anti-IgG antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-IgG antibody    Immunohistochemistry of paraffin-embedded human Pancreatic Cancer using MBS1488262 at dilution 1:100
anti-IgG antibody Immunohistochemistry (IHC) (IHC) image
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 Immunofluorescence (IF) of anti-IgG antibody    Immunofluorescent analysis of HepG2 cells using MBS1488262 at a dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
anti-IgG antibody Immunofluorescence (IF) image
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NCBI/Uniprot data below describe general gene information for IgG. It may not necessarily be applicable to this product.
 NCBI GI #    209862839
 NCBI GeneID    2217
 NCBI Accession #    NP_001129491.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001136019.2 [Other Products]
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 UniProt Primary Accession #    P55899 [Other Products]
 UniProt Secondary Accession #    Q5HYM5; Q9HBV7; Q9NZ19 [Other Products]
 UniProt Related Accession #    P55899 [Other Products]
 Molecular Weight    39,743 Da
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 NCBI Official Full Name    IgG receptor FcRn large subunit p51
 NCBI Official Synonym Full Names    Fc fragment of IgG receptor and transporter
 NCBI Official Symbol    FCGRT [Similar Products]
 NCBI Official Synonym Symbols   
FCRN; alpha-chain
[Similar Products]
 NCBI Protein Information    IgG receptor FcRn large subunit p51
 UniProt Protein Name    IgG receptor FcRn large subunit p51
 UniProt Synonym Protein Names   
IgG Fc fragment receptor transporter alpha chain; Neonatal Fc receptor
 Protein Family    IgG receptor
 UniProt Gene Name    FCGRT [Similar Products]
 UniProt Synonym Gene Names    FCRN; FcRn [Similar Products]
 UniProt Entry Name    FCGRN_HUMAN
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 NCBI Summary for IgG    This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
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 UniProt Comments for IgG    FCGRT: Binds to the Fc region of monomeric immunoglobulins gamma. Mediates the uptake of IgG from milk. Possible role in transfer of immunoglobulin G from mother to fetus. Belongs to the immunoglobulin superfamily.

Protein type: Membrane protein, integral; Immunoglobulin superfamily; Receptor, misc.

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: integral to membrane; plasma membrane

Molecular Function: antigen binding; beta-2-microglobulin binding; IgG binding; IgG receptor activity; peptide antigen binding

Biological Process: antigen processing and presentation; IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor; immune response
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 Research Articles on IgG    1. none of the three functional polymorphisms in FcgammaR genes explored here, the FCGR3A F158V and FCGR2B I232T nsSNPs and the VNTR in FCGRT, showed an association with the response to TNFi in patients with rheumatoid arthritis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IgG antibodyDiseases associated with anti-IgG antibody
 Reference Product  PubMed Publications
 B2M antibody  >3 publications with IgG and B2M
 FCGR2B antibody  >2 publications with IgG and FCGR2B
 FCGR2A antibody  >2 publications with IgG and FCGR2A
 FCGR3A antibody  >1 publications with IgG and FCGR3A
 ALB antibody  >1 publications with IgG and ALB
 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >3 publications with IgG and Immune System Diseases
 Kidney Diseases Antibodies  >2 publications with IgG and Kidney Diseases
 Necrosis Antibodies  >1 publications with IgG and Necrosis
Organs/Tissues associated with anti-IgG antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >10 publications with IgG and Blood
 Intestine Antibodies  >3 publications with IgG and Intestine
 Eye Antibodies  >2 publications with IgG and Eye
 Kidney Antibodies  >2 publications with IgG and Kidney
 Spleen Antibodies  >1 publications with IgG and Spleen
 Prostate Antibodies  >1 publications with IgG and Prostate
 Adipose Tissue Antibodies  >1 publications with IgG and Adipose Tissue
 Testis Antibodies  >1 publications with IgG and Testis
 Epididymis Antibodies  >1 publications with IgG and Epididymis
 Vascular Antibodies  >1 publications with IgG and Vascular
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