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anti-IgM antibody :: Sheep IgM Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS235397 anti-IgM antibody
Unit / Price
1 mL  /  $285 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

IgM, Polyclonal Antibody

★Popular Item★
 Also Known As   

SHEEP ANTI HUMAN IgM

 Product Gene Name   

anti-IgM antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147020
 3D Structure    ModBase 3D Structure for P01871
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Sheep
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 Specificity    This item recognises IgM. It does not exhibit cross-reactivity with albumin and human IgG. This antibody also has minimal cross reactivity with the following immunoglobulins.
Mouse IgG
 Form/Format    Serum
Serum - liquid
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 Perservative Stabilisers    0.09% Sodium Azide (NaN3)
 Immunogen    Human IgM isolated from pooled normal serum
 Target Species    Human
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 Preparation and Storage    Store at 4 degree C or at -20 degree C if preferred. Storage in frost-free freezers is not recommended. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
Shelf Life: 18 months from date of despatch.
 Other Notes    Small volumes of anti-IgM antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IgM antibody

   MBS235397 recognises IgM. It does not exhibit cross-reactivity with albumin and human IgG. This antibody also has minimal cross reactivity with the following immunoglobulins. Mouse IgG
 Applications Tested/Suitable for anti-IgM antibody   

ELISA (EIA), Immunodiffusion (ID), Immunoprecipitation (IP)

 Application Notes for anti-IgM antibody    ELISA: Minimum Dilution: 1/50K; Maximum Dilution: 1/250K;
Immunodiffusion: Maximum Dilution: 1/32
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NCBI/Uniprot data below describe general gene information for IgM. It may not necessarily be applicable to this product.
 NCBI GI #    193806374
 NCBI GeneID    3507
 NCBI Accession #    P01871.3 [Other Products]
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 UniProt Primary Accession #    P01871 [Other Products]
 UniProt Secondary Accession #    P20769 [Other Products]
 UniProt Related Accession #    P01871 [Other Products]
 Molecular Weight    51,790 Da
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 NCBI Official Full Name    Ig mu chain C region, partial
 NCBI Official Synonym Full Names    immunoglobulin heavy constant mu
 NCBI Official Symbol    IGHM [Similar Products]
 NCBI Official Synonym Symbols   
MU; VH; AGM1
[Similar Products]
 UniProt Protein Name    Ig mu chain C region
 Protein Family    IgM protease
 UniProt Gene Name    IGHM [Similar Products]
 UniProt Entry Name    IGHM_HUMAN
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 NCBI Summary for IgM    Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).[supplied by OMIM, Aug 2010]
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 UniProt Comments for IgM    IGHM: IgM antibodies play an important role in primary defense mechanisms. They have been shown to be involved in early recognition of external invaders like bacteria and viruses, cellular waste and modified self, as well as in recognition and elimination of precancerous and cancerous lesions. The membrane- bound form is found in the majority of normal B-cells alongside with IgD. Membrane-bound IgM induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. It may cause death of cells by apoptosis. It is also found in soluble form, which represents about 30% of the total serum immunoglobulins where it is found almost exclusively as an homopentamer. After the antigen binds to the B-cell receptor, the secreted form is secreted in large amounts. Defects in IGHM are the cause of agammaglobulinemia type 1 (AGM1). It is a primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: extracellular space; cell surface; integral to membrane; plasma membrane

Molecular Function: peptidoglycan binding; phosphatidylcholine binding; antigen binding; single-stranded DNA binding

Biological Process: adaptive immune response; antibacterial humoral response; innate immune response; defense response to Gram-negative bacterium

Disease: Agammaglobulinemia 1, Autosomal Recessive
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 Research Articles on IgM    1. Rearrangement of the immunoglobulin mu-chain gene is associated with acute myeloid leukemia.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IgM antibodyPathways associated with anti-IgM antibody
 Reference Product  PubMed Publications
 IGHG1 antibody  >6 publications with IgM and IGHG1
 CD19 antibody  >3 publications with IgM and CD19
 IGLL1 antibody  >3 publications with IgM and IGLL1
 IGHG4 antibody  >3 publications with IgM and IGHG4
 VPREB1 antibody  >1 publications with IgM and VPREB1
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Signaling By The B Cell Receptor (BCR) Pathway antibodies  Signaling By The B Cell Receptor (BCR) Pathway Diagram
Organs/Tissues associated with anti-IgM antibody
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18 publications with IgM and Blood
 Bone Antibodies  >4 publications with IgM and Bone
 Bone Marrow Antibodies  >3 publications with IgM and Bone Marrow
 Kidney Antibodies  >2 publications with IgM and Kidney
 Spleen Antibodies  >2 publications with IgM and Spleen
 Brain Antibodies  >1 publications with IgM and Brain
 Testis Antibodies  >1 publications with IgM and Testis
 Ovary Antibodies  >1 publications with IgM and Ovary
 Thymus Antibodies  >1 publications with IgM and Thymus
 Heart Antibodies  >1 publications with IgM and Heart
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