NP_034674.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Related Accession #
NCBI Official Full Name
indian hedgehog protein
NCBI Official Synonym Full Names
Indian hedgehog
NCBI Protein Information
indian hedgehog protein
UniProt Protein Name
Hedgehog protein
UniProt Entry Name
Q80XI9_MOUSE
UniProt Comments for Q80XI9
IHH: Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP). Expressed in embryonic lung, and in adult kidney and liver. Belongs to the hedgehog family.
Cellular Component: proteinaceous extracellular matrix; membrane; plasma membrane; extracellular region
Molecular Function: peptidase activity; protein binding; hydrolase activity; metal ion binding; patched binding; calcium ion binding
Biological Process: vitelline membrane formation; proteoglycan metabolic process; multicellular organismal development; positive regulation of collagen biosynthetic process; cell maturation; cell fate specification; proteolysis; embryonic pattern specification; positive regulation of T cell differentiation in the thymus; smooth muscle development; cell-cell signaling; vasculature development; embryonic digestive tract morphogenesis; regulation of cell differentiation; regulation of growth; pancreas development; positive regulation of cell proliferation; positive regulation of mesenchymal cell proliferation; positive regulation of smoothened signaling pathway; cell communication; heart looping; cell differentiation; skeletal development; bone resorption; negative regulation of immature T cell proliferation in the thymus; smoothened signaling pathway; ossification; camera-type eye development; intein-mediated protein splicing; in utero embryonic development; multicellular organism growth; negative regulation of eye pigmentation; morphogenesis of a branching structure; negative regulation of T cell differentiation in the thymus; pattern specification process; negative regulation of signal transduction; patterning of blood vessels; osteoblast differentiation; negative regulation of cell differentiation; embryonic development; positive regulation of chondrocyte differentiation; cartilage development; neuron development; positive regulation of transcription from RNA polymerase II promoter; embryonic camera-type eye morphogenesis; embryonic digit morphogenesis; positive regulation of alpha-beta T cell differentiation; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; negative regulation of alpha-beta T cell differentiation
Product References and Citations for anti-Q80XI9 antibody
Kobayashi,T., Proc. Natl. Acad. Sci. U.S.A. 105 (6), 1949-1954 (2008) Gat-Yablonski,G.,J. Pediatr. Endocrinol. Metab. 20 (11), 1215-1222 (2007) Koyama,E., Ann. N. Y. Acad. Sci. 1116, 100-112 (2007)
Research Articles on Q80XI9
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Products associated with anti-Q80XI9 antibody
Pathways associated with anti-Q80XI9 antibody
Diseases associated with anti-Q80XI9 antibody
Organs/Tissues associated with anti-Q80XI9 antibody
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