NP_036774.4
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
renin
NCBI Official Synonym Full Names
renin
NCBI Protein Information
renin; angiotensinogenase; renin 1 structural
UniProt Protein Name
Renin
UniProt Synonym Protein Names
Angiotensinogenase
UniProt Synonym Gene Names
UniProt Entry Name
RENI_RAT
NCBI Summary for REN
catalyzes the cleavage of a Leu-Xaa bond in angiotensinogen to generate angiotensin [RGD, Feb 2006]
UniProt Comments for REN
REN: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Interacts with ATP6AP2. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Belongs to the peptidase A1 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Protease; EC 3.4.23.15; Secreted; Secreted, signal peptide
Cellular Component: extracellular space; membrane; cytoplasm; intracellular
Molecular Function: peptidase activity; insulin-like growth factor receptor binding; endopeptidase activity; aspartic-type endopeptidase activity; receptor binding
Biological Process: response to drug; response to cAMP; hormone-mediated signaling; establishment of blood-nerve barrier; renin-angiotensin regulation of aldosterone production; drinking behavior; male gonad development; cell maturation; response to lipopolysaccharide; proteolysis; angiotensin maturation; response to organic substance; beta-amyloid metabolic process; regulation of blood pressure; regulation of MAPKKK cascade; renin-angiotensin regulation of blood volume; mesonephros development; kidney development
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Pathways associated with anti-REN antibody
Diseases associated with anti-REN antibody
Organs/Tissues associated with anti-REN antibody
|