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anti-Ido1 antibody :: Sheep anti-Human Indoleamine 2,3-Dioxygenase Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS620542 anti-Ido1 antibody
Unit / Price
0.1 mg  /  $575 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Indoleamine 2,3-Dioxygenase (Ido1), Polyclonal Antibody

 Also Known As   

Indoleamine 2,3-Dioxygenase (IDO, Indoleamine-pyrrole 2,3-dioxygenase)

 Product Synonym Names    Anti -Indoleamine 2,3-Dioxygenase (IDO, Indoleamine-pyrrole 2,3-dioxygenase)
 Product Gene Name   

anti-Ido1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 8; NC_000074.5 (25694613..25707481, complement). Location: 8 A2; 8
 3D Structure    ModBase 3D Structure for P28776
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Sheep
 Species Reactivity    Human
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 Specificity    Recognizes human IDO at 44kD.
 Purity/Purification    Serum
 Form/Format    Supplied as a liquid in 0.1% sodium azide.
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 Immunogen    Recombinant to human IDO (Indoleamine-pyrrol 2,3-dioxygenase) protein
 Positive Control    IFN- -stimmulated human peripheral blood lymphocytes
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 Preparation and Storage    May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add glycerol (40-50%), aliquot and store at -20 degree C or colder. Aliquots are stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
 Other Notes    Small volumes of anti-Ido1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-Ido1 antibody

   Indoleamine 2,3-dioxygenase (IDO), a monomeric hemoprotein, is the initial and rate-limiting enzyme of the kynurenine pathway of degradation of L-tryptophan. IDO oxidizes the pyrrole moiety of tryptophan,1 causing cell death due to tryptophan starvation.2 It is induced in various types of human cell lines and cell types such as fibroblasts, epithelial cells and macrophages in the presence of IFN-.3,4 Placenta, lung and small intestine show high levels of IDO enzyme activity.5 IDO has been implicated in regulation of feto-maternal tolerance and protection against intracellular and extracellular pathogens. In the human female reproductive tract, endometrial glandular and surface epithelial cells show increasing IDO expression during the course of the menstrual cycle.6 IDO is also implicated in playing immuno-regulation. In vivo, IDO has
 Product Categories/Family for anti-Ido1 antibody    Antibodies; Abs to Enzymes, Oxidase
 Applications Tested/Suitable for anti-Ido1 antibody   

ELISA (EL/EIA), Western Blot (WB)

 Application Notes for anti-Ido1 antibody    Suitable for use in ELISA and Western Blot.
Dilution: ELISA: 1:100-1:200
Western Blot: 1:100-1:200
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NCBI/Uniprot data below describe general gene information for Ido1. It may not necessarily be applicable to this product.
 NCBI GI #    194047
 NCBI GeneID    15930
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 UniProt Primary Accession #    P28776 [Other Products]
 UniProt Related Accession #    P28776 [Other Products]
 Molecular Weight    45,641 Da [Similar Products]
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 NCBI Official Full Name    indoleamine 2,3-dioxygenase
 NCBI Official Synonym Full Names    indoleamine 2,3-dioxygenase 1
 NCBI Official Symbol    Ido1 [Similar Products]
 NCBI Official Synonym Symbols   
Ido; Indo
[Similar Products]
 NCBI Protein Information    indoleamine 2,3-dioxygenase 1; IDO-1; OTTMUSP00000022551; OTTMUSP00000022552; indole 2,3-dioxygenase; indoleamine-pyrrole 2,3 dioxygenase; indoleamine-pyrrole 2,3-dioxygenase
 UniProt Protein Name    Indoleamine 2,3-dioxygenase 1
 UniProt Synonym Protein Names   
Indoleamine-pyrrole 2,3-dioxygenase
 Protein Family    Indoleamine 2,3-dioxygenase
 UniProt Gene Name    Ido1 [Similar Products]
 UniProt Synonym Gene Names    Ido; Indo [Similar Products]
 UniProt Entry Name    I23O1_MOUSE
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 UniProt Comments for Ido1    INDO: Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen. Belongs to the indoleamine 2,3-dioxygenase family.

Protein type: EC; Oxidoreductase; Amino Acid Metabolism - tryptophan; Cell cycle regulation

Cellular Component: stereocilium bundle; smooth muscle contractile fiber; cytoplasm; cytosol

Molecular Function: amino acid binding; protein binding; dioxygenase activity; metal ion binding; heme binding; indoleamine 2,3-dioxygenase activity; oxidoreductase activity; oxygen binding; tryptophan 2,3-dioxygenase activity

Biological Process: positive regulation of T-helper 2 type immune response; negative regulation of interleukin-10 production; positive regulation of chronic inflammatory response; tryptophan catabolic process to kynurenine; positive regulation of apoptosis; positive regulation of interleukin-12 production; negative regulation of activated T cell proliferation; defense response; response to lipopolysaccharide; negative regulation of T cell proliferation; cytokine production during acute inflammatory response; inflammatory response; tryptophan catabolic process; multicellular organismal response to stress; positive regulation of T cell tolerance induction
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 Research Articles on Ido1    1. The authors demonstrate an increase in the rate of colonic epithelial cell turnover after inhibition of IDO in Trichuris muris-infected SCID mice, leading to a significant expulsion of parasite burden.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Pathways associated with anti-Ido1 antibodyDiseases associated with anti-Ido1 antibody
 Products by Pathway  Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Of Amino Acids And Derivatives Pathway antibodies  Metabolism Of Amino Acids And Derivatives Pathway Diagram
 Tryptophan Catabolism Pathway antibodies  Tryptophan Catabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Tryptophan Metabolism Pathway antibodies  Tryptophan Metabolism Pathway Diagram
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >8 publications with Ido1 and Inflammation
 Neoplasms Antibodies  >5 publications with Ido1 and Neoplasms
 Sepsis Antibodies  >2 publications with Ido1 and Sepsis
 Autoimmune Diseases Antibodies  >2 publications with Ido1 and Autoimmune Diseases
 Carcinoma Antibodies  >2 publications with Ido1 and Carcinoma
 Melanoma Antibodies  >1 publications with Ido1 and Melanoma
 Neoplasm Metastasis Antibodies  >1 publications with Ido1 and Neoplasm Metastasis
 Drug Toxicity Antibodies  >1 publications with Ido1 and Drug Toxicity
 Neoplasm Invasiveness Antibodies  >1 publications with Ido1 and Neoplasm Invasiveness
 Pancreatic Neoplasms Antibodies  >1 publications with Ido1 and Pancreatic Neoplasms
Organs/Tissues associated with anti-Ido1 antibody
 Organ/Tissue Name  Pubmed Publications
 Epididymis Antibodies  >1 publications with Ido1 and Epididymis
 Intestine Antibodies  >1 publications with Ido1 and Intestine
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