NP_001269979.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
20,120 Da
NCBI Official Full Name
ICOS ligand isoform b
NCBI Official Synonym Full Names
inducible T cell costimulator ligand
NCBI Official Synonym Symbols
B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L [Similar Products]
NCBI Protein Information
ICOS ligand
UniProt Protein Name
ICOS ligand
UniProt Synonym Protein Names
B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD_antigen: CD275
UniProt Synonym Gene Names
UniProt Comments for ICOSLG
ICOSLG: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function. Belongs to the immunoglobulin superfamily. BTN/MOG family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component: integral component of membrane; plasma membrane
Molecular Function: receptor binding
Biological Process: adaptive immune response; B cell activation; defense response; hyperosmotic response; positive regulation of activated T cell proliferation; signal transduction; T cell activation; T cell costimulation
Research Articles on ICOSLG
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Products associated with anti-ICOSLG antibody
Pathways associated with anti-ICOSLG antibody
Diseases associated with anti-ICOSLG antibody
Organs/Tissues associated with anti-ICOSLG antibody
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