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anti-ICOSLG antibody :: Rabbit anti-Human Inducible T-Cell Co Stimulator Ligand (ICOSLG) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2014003 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $165 +1 FREE 8GB USB
0.1 mg  /  $210 +1 FREE 8GB USB
0.2 mg  /  $305 +1 FREE 8GB USB
1 mg  /  $720 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Inducible T-Cell Co Stimulator Ligand (ICOSLG), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Inducible T-Cell Co Stimulator Ligand (ICOSLG)

 Product Gene Name   

anti-ICOSLG antibody

[Similar Products]
 Matching Pairs    Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2014003)
Antigen: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2018340)
 Matching Pairs    Unconjugated Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2014003)
APC-CY7 Conjugated Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2047438)
 Matching Pairs    Unconjugated Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2014003)
PE Conjugated Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2047439)
 Matching Pairs    Unconjugated Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2014003)
APC-CY7 Conjugated Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2047440)
 Matching Pairs    Unconjugated Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2014003)
Cy3 Conjugated Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2047441)
 Matching Pairs    Unconjugated Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2014003)
FITC Conjugated Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2047442)
 Matching Pairs    Unconjugated Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2014003)
HRP Conjugated Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2047443)
 Matching Pairs    Unconjugated Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2014003)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2014003)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Matching Pairs    Unconjugated Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2014003)
Biotin Conjugated Antibody: Inducible T-Cell Co Stimulator Ligand (ICOSLG) (MBS2092484)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    Antigen: The target protein is fused with two N-terminal Tags, His-tag and T7-tag and its sequence is listed below.
MGSSHHHHHH SSGLVPRGSH MASMTGGQQM GRGSEF- KEVRAMVG SDVELSCACP EGSRFDLNDV YVYWQTSESK TVVTYHIPQN SSLENVDSRY RNRALMSPAG MLRGDFSLRL FNVTPQDEQK FHCLVLSQSL GFQEVLSVEV TLHVAANFSV PVVSAPHSPS QDELTFTCTS INGYPRPNVY WINKTDNSLL DQALQNDTVF LNMRGLYDVV SVLRIARTPS VNIGCCIENV
 OMIM    AF199028 mRNA
 3D Structure    ModBase 3D Structure for O75144
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against ICOSLG. It has been selected for its ability to recognize ICOSLG in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant ICOSLG (Lys23~Thr249) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2047440
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-ICOSLG antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-ICOSLG antibody    Knock-Out Validation Antibody
 Applications Tested/Suitable for anti-ICOSLG antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-ICOSLG antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) Knockout Verification of anti-ICOSLG antibody    Knockout Verification: Lane 1: Wild-type Jurkat cell lysate; Lane 2: ICOSLG knockout Jurkat cell lysate; Predicted MW: 33kd Observed MW: 27kd Primary Ab: 2ug/ml Rabbit Anti-Human ICOSLG Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-ICOSLG antibody Western Blot (WB) Knockout Verification (WB) image
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 Western Blot (WB) of anti-ICOSLG antibody    Western Blot; Sample: Lane1: Human Serum; Lane2: Human Liver Tissue; Lane3: Human Lung Tissue; Lane4: Human Jurkat Cells.
anti-ICOSLG antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-ICOSLG antibody    Western Blot; Sample: Recombinant ICOSLG, Human.
anti-ICOSLG antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ICOSLG antibody    DAB staining on fromalin fixed paraffin-embedded Kidney tissue)
anti-ICOSLG antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ICOSLG antibody    DAB staining on IHC-P; Samples: Human Tonsil Tissue)
anti-ICOSLG antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ICOSLG. It may not necessarily be applicable to this product.
 NCBI GI #    545688560
 NCBI GeneID    23308
 NCBI Accession #    NP_001269979.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001283050.1 [Other Products]
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 UniProt Primary Accession #    O75144 [Other Products]
 UniProt Secondary Accession #    Q9HD18; Q9NRQ1; A8MUZ1 [Other Products]
 UniProt Related Accession #    O75144 [Other Products]
 Molecular Weight    20,120 Da
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 NCBI Official Full Name    ICOS ligand isoform b
 NCBI Official Synonym Full Names    inducible T cell costimulator ligand
 NCBI Official Symbol    ICOSLG [Similar Products]
 NCBI Official Synonym Symbols   
B7H2; GL50; B7-H2; B7RP1; CD275; ICOSL; LICOS; B7RP-1; ICOS-L
[Similar Products]
 NCBI Protein Information    ICOS ligand
 UniProt Protein Name    ICOS ligand
 UniProt Synonym Protein Names   
B7 homolog 2; B7-H2; B7-like protein Gl50; B7-related protein 1; B7RP-1; CD_antigen: CD275
 Protein Family    ICOS ligand
 UniProt Gene Name    ICOSLG [Similar Products]
 UniProt Synonym Gene Names    B7H2; B7RP1; ICOSL; KIAA0653; B7-H2; B7RP-1 [Similar Products]
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 UniProt Comments for ICOSLG    ICOSLG: Ligand for the T-cell-specific cell surface receptor ICOS. Acts as a costimulatory signal for T-cell proliferation and cytokine secretion; induces also B-cell proliferation and differentiation into plasma cells. Could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co- stimulating memory T-cell function. Belongs to the immunoglobulin superfamily. BTN/MOG family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.3

Cellular Component: integral component of membrane; plasma membrane

Molecular Function: receptor binding

Biological Process: adaptive immune response; B cell activation; defense response; hyperosmotic response; positive regulation of activated T cell proliferation; signal transduction; T cell activation; T cell costimulation
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 Research Articles on ICOSLG    1. study confirms the importance of ICOSL shedding in ICOS/ICOSL function and expression and it identifies ADAM10 as the most important sheddase for controlling ICOSL levels
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ICOSLG antibodyPathways associated with anti-ICOSLG antibody
 Reference Product  PubMed Publications
 ICOS antibody  >60 publications with ICOSLG and ICOS
 TNFSF18 antibody  >4 publications with ICOSLG and TNFSF18
 PTPRC antibody  >2 publications with ICOSLG and PTPRC
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
Diseases associated with anti-ICOSLG antibodyOrgans/Tissues associated with anti-ICOSLG antibody
 Disease Name  Pubmed Publications
 Necrosis Antibodies  >21 publications with ICOSLG and Necrosis
 Autoimmune Diseases Antibodies  >16 publications with ICOSLG and Autoimmune Diseases
 Inflammation Antibodies  >14 publications with ICOSLG and Inflammation
 Asthma Antibodies  >8 publications with ICOSLG and Asthma
 Lung Diseases Antibodies  >7 publications with ICOSLG and Lung Diseases
 Carcinoma Antibodies  >6 publications with ICOSLG and Carcinoma
 Cardiovascular Diseases Antibodies  >5 publications with ICOSLG and Cardiovascular Diseases
 Colitis, Ulcerative Antibodies  >3 publications with ICOSLG and Colitis, Ulcerative
 Celiac Disease Antibodies  >3 publications with ICOSLG and Celiac Disease
 Carcinoma, Squamous Cell Antibodies  >2 publications with ICOSLG and Carcinoma, Squamous Cell
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >78 publications with ICOSLG and Blood
 Lymph Node Antibodies  >6 publications with ICOSLG and Lymph Node
 Brain Antibodies  >6 publications with ICOSLG and Brain
 Lung Antibodies  >5 publications with ICOSLG and Lung
 Kidney Antibodies  >4 publications with ICOSLG and Kidney
 Liver Antibodies  >4 publications with ICOSLG and Liver
 Skin Antibodies  >4 publications with ICOSLG and Skin
 Heart Antibodies  >4 publications with ICOSLG and Heart
 Stomach Antibodies  >2 publications with ICOSLG and Stomach
 Connective Tissue Antibodies  >2 publications with ICOSLG and Connective Tissue
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