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anti-INHBB antibody :: Rabbit anti-Human Inhibin beta B chain Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1489337 anti-INHBB antibody
Unit / Price
0.05 mg  /  $160 +1 FREE 8GB USB
0.1 mg  /  $235 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Inhibin beta B chain (INHBB), Polyclonal Antibody

 Also Known As   

Rabbit anti-human Inhibin beta B chain polyclonal Antibody, HRP conjugated

 Product Synonym Names    Activin beta-B chain
 Product Gene Name   

anti-INHBB antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    147390
 3D Structure    ModBase 3D Structure for P09529
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Caprylic Acid Ammonium Sulfate Precipitation Purified
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 Storage Buffer    Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
 Conjugate    HRP
 Immunogen    Recombinant human Inhibin beta B chain protein
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-6307 / sc-6306 / sc-50287
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-INHBB antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-INHBB antibody

   Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
 Applications Tested/Suitable for anti-INHBB antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for INHBB. It may not necessarily be applicable to this product.
 NCBI GI #    154813204
 NCBI GeneID    3625
 NCBI Accession #    NP_002184.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_002193.2 [Other Products]
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 UniProt Primary Accession #    P09529 [Other Products]
 UniProt Secondary Accession #    Q53T31; Q8N1D3 [Other Products]
 UniProt Related Accession #    P09529 [Other Products]
 Molecular Weight    45,122 Da
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 NCBI Official Full Name    inhibin beta B chain preproprotein
 NCBI Official Synonym Full Names    inhibin beta B
 NCBI Official Symbol    INHBB [Similar Products]
 NCBI Protein Information    inhibin beta B chain
 UniProt Protein Name    Inhibin beta B chain
 UniProt Synonym Protein Names   
Activin beta-B chain
 Protein Family    Inhibin
 UniProt Gene Name    INHBB [Similar Products]
 UniProt Entry Name    INHBB_HUMAN
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 NCBI Summary for INHBB    The inhibin beta B subunit joins the alpha subunit to form a pituitary FSH secretion inhibitor. Inhibin has been shown to regulate gonadal stromal cell proliferation negatively and to have tumour-suppressor activity. In addition, serum levels of inhibin have been shown to reflect the size of granulosa-cell tumors and can therefore be used as a marker for primary as well as recurrent disease. Because expression in gonadal and various extragonadal tissues may vary severalfold in a tissue-specific fashion, it is proposed that inhibin may be both a growth/differentiation factor and a hormone. Furthermore, the beta B subunit forms a homodimer, activin B, and also joins with the beta A subunit to form a heterodimer, activin AB, both of which stimulate FSH secretion. [provided by RefSeq, Jul 2008]
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 UniProt Comments for INHBB    INHBB: Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Belongs to the TGF-beta family.

Protein type: Cell development/differentiation; Cytokine; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 2cen-q13

Cellular Component: extracellular region; extracellular space; perinuclear region of cytoplasm

Molecular Function: cytokine activity; growth factor activity; hormone activity; host cell surface receptor binding; protein binding; protein homodimerization activity; transforming growth factor beta receptor binding

Biological Process: activin receptor signaling pathway; cell development; cell differentiation; cellular response to insulin stimulus; cellular response to starvation; defense response; fat cell differentiation; growth; negative regulation of follicle-stimulating hormone secretion; negative regulation of hepatocyte growth factor biosynthetic process; negative regulation of insulin secretion; oocyte development; ovarian follicle development; positive regulation of follicle-stimulating hormone secretion; regulation of apoptosis; regulation of MAPKKK cascade; response to mechanical stimulus
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 Research Articles on INHBB    1. reduction of RhoA signaling by Activin B together with persistent Rac1 activity is a prerequisite for inducing an invasive phenotype in clear cell renal cell carcinoma.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-INHBB antibodyPathways associated with anti-INHBB antibody
 Reference Product  PubMed Publications
 INHBA antibody  >25 publications with INHBB and INHBA
 INHA antibody  >19 publications with INHBB and INHA
 FST antibody  >8 publications with INHBB and FST
 ACVR1C antibody  >4 publications with INHBB and ACVR1C
 ACVR2A antibody  >4 publications with INHBB and ACVR2A
 FSHB antibody  >3 publications with INHBB and FSHB
 INHBC antibody  >3 publications with INHBB and INHBC
 ACVR1B antibody  >3 publications with INHBB and ACVR1B
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Activin Signaling Pathway antibodies  Activin Signaling Pathway Diagram
 Antagonism Of Activin By Follistatin Pathway antibodies  Antagonism Of Activin By Follistatin Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Glycoprotein Hormones Pathway antibodies  Glycoprotein Hormones Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Biosynthesis Pathway antibodies  Peptide Hormone Biosynthesis Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
Diseases associated with anti-INHBB antibodyOrgans/Tissues associated with anti-INHBB antibody
 Disease Name  Pubmed Publications
 Adenocarcinoma Antibodies  >7 publications with INHBB and Adenocarcinoma
 Ovarian Neoplasms Antibodies  >7 publications with INHBB and Ovarian Neoplasms
 Infertility, Male Antibodies  >7 publications with INHBB and Infertility, Male
 Inflammation Antibodies  >5 publications with INHBB and Inflammation
 Breast Neoplasms Antibodies  >4 publications with INHBB and Breast Neoplasms
 Weight Loss Antibodies  >4 publications with INHBB and Weight Loss
 Congenital Abnormalities Antibodies  >4 publications with INHBB and Congenital Abnormalities
 Prostatic Neoplasms Antibodies  >4 publications with INHBB and Prostatic Neoplasms
 Oligospermia Antibodies  >3 publications with INHBB and Oligospermia
 Disease Models, Animal Antibodies  >3 publications with INHBB and Disease Models, Animal
 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >21 publications with INHBB and Testis
 Brain Antibodies  >12 publications with INHBB and Brain
 Uterus Antibodies  >9 publications with INHBB and Uterus
 Liver Antibodies  >6 publications with INHBB and Liver
 Prostate Antibodies  >5 publications with INHBB and Prostate
 Kidney Antibodies  >5 publications with INHBB and Kidney
 Pancreas Antibodies  >5 publications with INHBB and Pancreas
 Eye Antibodies  >4 publications with INHBB and Eye
 Lung Antibodies  >3 publications with INHBB and Lung
 Nerve Antibodies  >2 publications with INHBB and Nerve
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