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anti-IGFBP3 antibody :: Rabbit Insulin Like Growth Factor Binding Protein 3 (IGFBP3) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2005953 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.1 mg  /  $170 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Insulin Like Growth Factor Binding Protein 3 (IGFBP3), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Insulin Like Growth Factor Binding Protein 3 (IGFBP3)

 Product Gene Name   

anti-IGFBP3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 4; AC_000161.1 (76705105..76713511). Location: chromosome: 4
 3D Structure    ModBase 3D Structure for P20959
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Homo sapiens (Human)
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 Specificity    The antibody is a rabbit polyclonal antibody raised against IGFBP3. It has been selected for its ability to recognize IGFBP3 in immunohistochemical staining and western blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-IGFBP3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-IGFBP3 antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-IGFBP3 antibody    Western blotting: 1:50-400
Immunocytochemistry in formalin fixed cells: 1:50-500
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Immunohistochemistry in paraffin section: 1:10-100
Enzyme-linked Immunosorbent Assay: 1:100-200
Optimal working dilutions must be determined by end user.
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 Western Blot (WB) of anti-IGFBP3 antibody    (Figure. Western Blot; Sample: Recombinant protein.)
anti-IGFBP3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-IGFBP3 antibody    (Figure.DAB staining on IHC-P. Samples: Human Tissue)
anti-IGFBP3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for IGFBP3. It may not necessarily be applicable to this product.
 NCBI GI #    27807007
 NCBI GeneID    282261
 NCBI Accession #    NP_776981.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_174556.1 [Other Products]
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 UniProt Primary Accession #    P20959 [Other Products]
 UniProt Secondary Accession #    Q9GJV5; A6QPI3 [Other Products]
 UniProt Related Accession #    P20959 [Other Products]
 Molecular Weight    31,570 Da
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 NCBI Official Full Name    insulin-like growth factor-binding protein 3
 NCBI Official Synonym Full Names    insulin-like growth factor binding protein 3<
 NCBI Official Symbol    IGFBP3 [Similar Products]
 NCBI Official Synonym Symbols   
IGFBP-3
[Similar Products]
 NCBI Protein Information    insulin-like growth factor-binding protein 3; IBP-3; IGF-binding protein 3; insulin-like growth factor binding protein-3
 UniProt Protein Name    Insulin-like growth factor-binding protein 3
 Protein Family    Insulin-like growth factor-binding protein
 UniProt Gene Name    IGFBP3 [Similar Products]
 UniProt Synonym Gene Names    IBP-3; IGF-binding protein 3; IGFBP-3 [Similar Products]
 UniProt Entry Name    IBP3_BOVIN
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 UniProt Comments for IGFBP3    Function: IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

Subunit structure: Interacts with HN. Interacts with TMEM219

By similarity. Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with XLKD1. Ref.6

Subcellular location: Secreted.

Tissue specificity: Plasma; expressed by most tissues.

Post-translational modification: Phosphorylation sites are present in the extracellular medium

By similarity.

Sequence similarities: Contains 1 IGFBP N-terminal domain.Contains 1 thyroglobulin type-1 domain.
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 Research Articles on IGFBP3    1. The present study suggests that the insulin like growth factor (IGF) system or imbalances between IGF and IGF binding proteins may be involved in cystic ovary disease of cattle.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IGFBP3 antibodyPathways associated with anti-IGFBP3 antibody
 Reference Product  PubMed Publications
 IGF1 antibody  >190 publications with IGFBP3 and IGF1
 IGF2 antibody  >68 publications with IGFBP3 and IGF2
 IGFALS antibody  >18 publications with IGFBP3 and IGFALS
 PRL antibody  >18 publications with IGFBP3 and PRL
 TP53 antibody  >11 publications with IGFBP3 and TP53
 INS antibody  >6 publications with IGFBP3 and INS
 BMP4 antibody  >5 publications with IGFBP3 and BMP4
 FN1 antibody  >1 publications with IGFBP3 and FN1
 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway antibodies  Regulation Of Insulin-like Growth Factor (IGF) Transport And Uptake By Insulin-like Growth Factor Binding Proteins (IGFBPs) Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 Transcriptional Misregulation In Cancer Pathway antibodies  Transcriptional Misregulation In Cancer Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
 P53 Signaling Pathway antibodies  P53 Signaling Pathway Diagram
Diseases associated with anti-IGFBP3 antibodyOrgans/Tissues associated with anti-IGFBP3 antibody
 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >1218 publications with IGFBP3 and Neoplasms
 Breast Neoplasms Antibodies  >331 publications with IGFBP3 and Breast Neoplasms
 Prostatic Neoplasms Antibodies  >251 publications with IGFBP3 and Prostatic Neoplasms
 Cardiovascular Diseases Antibodies  >211 publications with IGFBP3 and Cardiovascular Diseases
 Adenocarcinoma Antibodies  >165 publications with IGFBP3 and Adenocarcinoma
 Colorectal Neoplasms Antibodies  >140 publications with IGFBP3 and Colorectal Neoplasms
 Liver Diseases Antibodies  >138 publications with IGFBP3 and Liver Diseases
 Kidney Diseases Antibodies  >120 publications with IGFBP3 and Kidney Diseases
 Inflammation Antibodies  >119 publications with IGFBP3 and Inflammation
 Necrosis Antibodies  >106 publications with IGFBP3 and Necrosis
 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >404 publications with IGFBP3 and Liver
 Muscle Antibodies  >285 publications with IGFBP3 and Muscle
 Kidney Antibodies  >201 publications with IGFBP3 and Kidney
 Brain Antibodies  >194 publications with IGFBP3 and Brain
 Lung Antibodies  >172 publications with IGFBP3 and Lung
 Ovary Antibodies  >157 publications with IGFBP3 and Ovary
 Skin Antibodies  >107 publications with IGFBP3 and Skin
 Uterus Antibodies  >71 publications with IGFBP3 and Uterus
 Pituitary Gland Antibodies  >68 publications with IGFBP3 and Pituitary Gland
 Intestine Antibodies  >65 publications with IGFBP3 and Intestine
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