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anti-INSR antibody :: Rabbit Insulin Receptor Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS629149
Western Blot
Unit / Price
0.1 mL  /  $655 +1 FREE 8GB USB
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Insulin Receptor (INSR), Polyclonal Antibody

★Popular Item★
 Also Known As   

Insulin Receptor, phosphorylated (Tyr972) (IR)

 Product Synonym Names    Anti -Insulin Receptor, phosphorylated (Tyr972) (IR)
 Product Gene Name   

anti-INSR antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 19; NC_000019.9 (7112266..7294011, complement). Location: 19p13.3-p13.2
 OMIM    125853
 3D Structure    ModBase 3D Structure for P06213
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    Recognizes phospho-IR (-subunit) (Tyr972) at approximately 95 kDa. Species Cross-reactivity: Human and Mouse tested. Predicted to cross-react with Rat (100% homologous), based on sequence homology.
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a liquid in PBS (without Mg2+ and Ca2+), pH 7.2, 1mg/ml BSA (IgG, protease free), 0.05% sodium azide, 50% glycerol.
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 Immunogen    Peptide corresponding to amino acid region encompassing the human, mouse and rat phospho-phospho-IR (Tyr972).
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 Preparation and Storage    May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at - 20 degree C For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
 Other Notes    Small volumes of anti-INSR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-INSR antibody    Antibodies; Abs to Receptors
 Applications Tested/Suitable for anti-INSR antibody   

Western Blot (WB)

 Application Notes for anti-INSR antibody    Suitable for use in Western Blot.
Recommended Dilution:
Western Blot: 1:1000 detects phosphorylated IR (Tyr972) in RIPA lysates of untreated and insulin treated CHO cells transfected with IR.
Optimal dilutions to be determined by the researcher.
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 Western Blot of anti-INSR antibody    Western Blot Analysis Untreated (Lane 1) or insulin treated (Lanes 2 and 3) Iysates from CHO cells transfected with IR were resolved by electrophoresis, transferred to nitrocellulose, and probed with MBS629149 for 2 hours at RT. Lane 3 was pre-incubated with the blocking peptide immunogen corresponding to phospho-IR (Tyr972). Proteins were visualized via HRP and chemiluminescent detection. Arrow indicates phospho-IR.
anti-INSR antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for INSR. It may not necessarily be applicable to this product.
 NCBI GI #    386830
 NCBI GeneID    3643
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 UniProt Primary Accession #    P06213 [Other Products]
 UniProt Secondary Accession #    Q17RW0; Q59H98; Q9UCB7; Q9UCB8; Q9UCB9 [Other Products]
 UniProt Related Accession #    P06213; Q2MKN9; Q2MKP0; Q2MKP2; Q2PJC1; Q2PJC2; Q2PJC3; Q2PJC4; Q2PJC5; Q4U0V1 [Other Products]
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 NCBI Official Full Name    insulin receptor
 NCBI Official Synonym Full Names    insulin receptor
 NCBI Official Symbol    INSR [Similar Products]
 NCBI Official Synonym Symbols   
HHF5; CD220
[Similar Products]
 NCBI Protein Information    insulin receptor; IR
 UniProt Protein Name    Insulin receptor
 Protein Family    Insulin receptor
 UniProt Entry Name    INSR_HUMAN
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 NCBI Summary for INSR    After removal of the precursor signal peptide, the insulin receptor precursor is post-translationally cleaved into two chains (alpha and beta) that are covalently linked. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
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 UniProt Comments for INSR    INSR: a receptor tyrosine kinase that mediates the pleiotropic actions of insulin. Binding of insulin leads to phosphorylation of several intracellular substrates, including, insulin receptor substrates (IRS1, 2, 3, 4), SHC, GAB1, CBL and other signaling intermediates. Each of these phosphorylated proteins serve as docking proteins for other signaling proteins that contain Src-homology-2 domains (SH2 domain) that specifically recognize different phosphotyrosines residues, including the p85 regulatory subunit of PI3K and SHP2. Phosphorylation of IRSs proteins lead to the activation of two main signaling pathways: the PI3K-AKT pathway, which is responsible for most of the metabolic actions of insulin, and the Ras-MAPK pathway, which regulates expression of some genes and cooperates with the PI3K pathway to control cell growth and differentiation. In addition to binding insulin, the insulin receptor can bind insulin-like growth factors (IGFI and IGFII). The holoenzyme is cleaved into two chains, the alpha and beta subunits. The active complex is a tetramer containing 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains constitute the ligand- binding domain, while the beta chains carry the kinase domain. Interacts with SORBS1 but dissociates from it following insulin stimulation. Familial mutations associated with insulin resistant diabetes, acanthosis nigricans, pineal hyperplasia, and polycystic ovary syndrome. SNP variants may be associated with polycystic ovary syndrome, atypical migraine and diabetic hyperlipidemia. Mutations also cause leprechaunism, a severe insulin resistance syndrome causing growth retardation and death in early infancy. Two isoforms of the human protein are produced by alternative splicing. The Short isoform has a higher affinity for insulin than the longer. Isoform Long and isoform Short are predominantly expressed in tissue targets of insulin metabolic effects: liver, adipose tissue and skeletal muscle but are also expressed in the peripheral nerve, kidney, pulmonary alveoli, pancreatic acini, placenta vascular endothelium, fibroblasts, monocytes, granulocytes, erythrocytes and skin. Isoform Short is preferentially expressed in fetal cells such as fetal fibroblasts, muscle, liver and kidney. Found as a hybrid receptor with IGF1R in muscle, heart, kidney, adipose tissue, skeletal muscle, hepatoma, fibroblasts, spleen and placenta. Overexpressed in several tumors, including breast, colon, lung, ovary, and thyroid carcinomas.

Protein type: Kinase, protein; EC; Protein kinase, tyrosine (receptor); Protein kinase, TK; Membrane protein, integral; TK group; InsR family

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: membrane; intracellular membrane-bound organelle; integral to plasma membrane; plasma membrane; endosome membrane; caveola; receptor complex

Molecular Function: insulin binding; insulin-like growth factor receptor binding; protein binding; insulin-like growth factor I binding; GTP binding; insulin receptor substrate binding; protein-tyrosine kinase activity; PTB domain binding; phosphoinositide 3-kinase binding; receptor signaling protein tyrosine kinase activity; insulin-like growth factor II binding; ATP binding; insulin receptor activity

Biological Process: heart morphogenesis; epidermis development; positive regulation of nitric oxide biosynthetic process; peptidyl-tyrosine phosphorylation; activation of MAPK activity; protein amino acid autophosphorylation; positive regulation of glycogen biosynthetic process; regulation of embryonic development; exocrine pancreas development; glucose homeostasis; positive regulation of glucose import; regulation of transcription, DNA-dependent; positive regulation of MAPKKK cascade; male sex determination; positive regulation of cell proliferation; protein heterotetramerization; positive regulation of developmental growth; positive regulation of mitosis; activation of protein kinase B; G-protein coupled receptor protein signaling pathway; positive regulation of protein kinase B signaling cascade; cellular response to insulin stimulus; positive regulation of glycolysis; carbohydrate metabolic process; activation of protein kinase activity; insulin receptor signaling pathway; positive regulation of protein amino acid phosphorylation; positive regulation of DNA replication; positive regulation of cell migration; transformation of host cell by virus

Disease: Diabetes Mellitus, Insulin-resistant, With Acanthosis Nigricans; Hyperinsulinemic Hypoglycemia, Familial, 5; Pineal Hyperplasia, Insulin-resistant Diabetes Mellitus, And Somatic Abnormalities; Donohue Syndrome
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 Research Articles on INSR    1. IGF1 might inhibit insulinogenic differentiation of HEAC, whereas IGF2 enhances differentiation, and enhancement of IGF2 appears to be mediated via IR
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-INSR antibodyPathways associated with anti-INSR antibody
 Reference Product  PubMed Publications
 IGF1R antibody  >53 publications with INSR and IGF1R
 IRS1 antibody  >32 publications with INSR and IRS1
 INS antibody  >19 publications with INSR and INS
 IGF2 antibody  >16 publications with INSR and IGF2
 IRS2 antibody  >14 publications with INSR and IRS2
 SRC antibody  >6 publications with INSR and SRC
 PIK3R1 antibody  >5 publications with INSR and PIK3R1
 INSRR antibody  >4 publications with INSR and INSRR
 SHC1 antibody  >3 publications with INSR and SHC1
 SOCS3 antibody  >3 publications with INSR and SOCS3
 Products by Pathway  Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Adherens Junction Pathway antibodies  Adherens Junction Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 IRS Activation Pathway antibodies  IRS Activation Pathway Diagram
 IRS-mediated Signalling Pathway antibodies  IRS-mediated Signalling Pathway Diagram
 IRS-related Events Pathway antibodies  IRS-related Events Pathway Diagram
 Insulin Pathway antibodies  Insulin Pathway Diagram
 Insulin Signaling Pathway antibodies  Insulin Signaling Pathway Diagram
Diseases associated with anti-INSR antibodyOrgans/Tissues associated with anti-INSR antibody
 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >85 publications with INSR and Insulin Resistance
 Hyperinsulinism Antibodies  >56 publications with INSR and Hyperinsulinism
 Neoplasms Antibodies  >50 publications with INSR and Neoplasms
 Diabetes Mellitus Antibodies  >44 publications with INSR and Diabetes Mellitus
 Diabetes Mellitus, Type 2 Antibodies  >30 publications with INSR and Diabetes Mellitus, Type 2
 Obesity Antibodies  >24 publications with INSR and Obesity
 Gonadal Disorders Antibodies  >16 publications with INSR and Gonadal Disorders
 Hypertension Antibodies  >15 publications with INSR and Hypertension
 Hyperglycemia Antibodies  >14 publications with INSR and Hyperglycemia
 Brain Diseases Antibodies  >11 publications with INSR and Brain Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >59 publications with INSR and Blood
 Muscle Antibodies  >32 publications with INSR and Muscle
 Liver Antibodies  >32 publications with INSR and Liver
 Brain Antibodies  >26 publications with INSR and Brain
 Ovary Antibodies  >22 publications with INSR and Ovary
 Adipose Tissue Antibodies  >14 publications with INSR and Adipose Tissue
 Pancreas Antibodies  >13 publications with INSR and Pancreas
 Connective Tissue Antibodies  >9 publications with INSR and Connective Tissue
 Vascular Antibodies  >9 publications with INSR and Vascular
 Bone Antibodies  >7 publications with INSR and Bone
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