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anti-ITGaX antibody :: Rabbit anti-Mouse Integrin Alpha X Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2027186 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Western Blot
Unit / Price
0.01 mg  /  $135 +1 FREE 8GB USB
0.05 mg  /  $230 +1 FREE 8GB USB
0.1 mg  /  $310 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Integrin Alpha X (ITGaX), Polyclonal Antibody

 Also Known As   

Polyclonal Antibody to Integrin Alpha X (ITGaX)

 Product Gene Name   

anti-ITGaX antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    151510
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Mouse
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 Purity/Purification    Antigen-specific Affinity Chromatography.
 Form/Format    Supplied as solution form in 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Source    Polyclonal antibody preparation
 Traits    Liquid
 Immunogen    Recombinant ITGaX (Arg907~Val1115) expressed in E.coli
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 Preparation and Storage    Storage:Avoid repeated freeze/thaw cycles.
Store at 4 degree C for frequent use.
Aliquot and store at -20 degree C for 12 months.
Stability Test:The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
 Other Notes    Small volumes of anti-ITGaX antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Applications Tested/Suitable for anti-ITGaX antibody   

WB; IHC; ICC; IP

 Application Notes for anti-ITGaX antibody    Western blotting: 0.5-2g/mL
Immunohistochemistry: 5-20g/mL
Immunocytochemistry: 5-20g/mL

Optimal working dilutions must be determined by end user
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 Western Blot of anti-ITGaX antibody    Western Blot
Sample: Recombinant ITGaX, Mouse
anti-ITGaX antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for ITGaX. It may not necessarily be applicable to this product.
 NCBI GI #    23398603
 NCBI GeneID    3687
 NCBI Accession #    AAH38237.1 [Other Products]
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 UniProt Secondary Accession #    Q8IVA6 [Other Products]
 UniProt Related Accession #    P20702 [Other Products]
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 NCBI Official Full Name    ITGAX protein
 NCBI Official Synonym Full Names    integrin, alpha X (complement component 3 receptor 4 subunit)
 NCBI Official Symbol    ITGAX [Similar Products]
 NCBI Official Synonym Symbols   
CD11C; SLEB6
[Similar Products]
 NCBI Protein Information    integrin alpha-X
 UniProt Protein Name    Integrin alpha-X
 UniProt Synonym Protein Names   
CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD_antigen: CD11c
 Protein Family    Integrin
 UniProt Gene Name    ITGAX [Similar Products]
 UniProt Synonym Gene Names    CD11C [Similar Products]
 UniProt Entry Name    ITAX_HUMAN
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 NCBI Summary for ITGaX    This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
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 UniProt Comments for ITGaX    ITGAX: Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Belongs to the integrin alpha chain family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 16p11.2

Cellular Component: cell surface; membrane; plasma membrane; integrin complex

Molecular Function: protein binding; metal ion binding; receptor activity

Biological Process: integrin-mediated signaling pathway; heterotypic cell-cell adhesion; extracellular matrix organization and biogenesis; organ morphogenesis; blood coagulation; cell adhesion; leukocyte migration

Disease: Systemic Lupus Erythematosus
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 Research Articles on ITGaX    1. infiltration of MBP(+) and CD11c(+) innate immune cells show a significant association with phenotype and disease extent of non-asthmatic chronic rhinosinusitis
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ITGaX antibodyPathways associated with anti-ITGaX antibody
 Reference Product  PubMed Publications
 ITGB2 antibody  >411 publications with ITGaX and ITGB2
 TNF antibody  >330 publications with ITGaX and TNF
 ICAM1 antibody  >141 publications with ITGaX and ICAM1
 PTPRC antibody  >15 publications with ITGaX and PTPRC
 CD8A antibody  >11 publications with ITGaX and CD8A
 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 ECM Proteoglycans Pathway antibodies  ECM Proteoglycans Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram
 Integrin Cell Surface Interactions Pathway antibodies  Integrin Cell Surface Interactions Pathway Diagram
 Integrin-mediated Cell Adhesion Pathway antibodies  Integrin-mediated Cell Adhesion Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Regulation Of Actin Cytoskeleton Pathway antibodies  Regulation Of Actin Cytoskeleton Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
Diseases associated with anti-ITGaX antibodyOrgans/Tissues associated with anti-ITGaX antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >546 publications with ITGaX and Inflammation
 Necrosis Antibodies  >365 publications with ITGaX and Necrosis
 Disease Models, Animal Antibodies  >317 publications with ITGaX and Disease Models, Animal
 Lung Diseases Antibodies  >172 publications with ITGaX and Lung Diseases
 Cardiovascular Diseases Antibodies  >112 publications with ITGaX and Cardiovascular Diseases
 Neoplasms, Experimental Antibodies  >112 publications with ITGaX and Neoplasms, Experimental
 Vascular Diseases Antibodies  >102 publications with ITGaX and Vascular Diseases
 Liver Diseases Antibodies  >62 publications with ITGaX and Liver Diseases
 Atherosclerosis Antibodies  >51 publications with ITGaX and Atherosclerosis
 Kidney Diseases Antibodies  >47 publications with ITGaX and Kidney Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >2232 publications with ITGaX and Blood
 Bone Marrow Antibodies  >561 publications with ITGaX and Bone Marrow
 Spleen Antibodies  >461 publications with ITGaX and Spleen
 Lymph Node Antibodies  >421 publications with ITGaX and Lymph Node
 Lung Antibodies  >301 publications with ITGaX and Lung
 Intestine Antibodies  >147 publications with ITGaX and Intestine
 Brain Antibodies  >106 publications with ITGaX and Brain
 Thymus Antibodies  >78 publications with ITGaX and Thymus
 Eye Antibodies  >68 publications with ITGaX and Eye
 Kidney Antibodies  >66 publications with ITGaX and Kidney
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