NP_032430.2
[Other Products]
NCBI GenBank Nucleotide #
|
[Other Products]
UniProt Primary Accession #
|
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
85,026 Da
NCBI Official Full Name
integrin beta-2
NCBI Official Synonym Full Names
integrin beta 2
NCBI Official Synonym Symbols
2E6; LAD; Cd18; Lfa1; MF17; LCAMB; AI528527 [Similar Products]
NCBI Protein Information
integrin beta-2
UniProt Protein Name
Integrin beta-2
UniProt Synonym Protein Names
Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; CD_antigen: CD18
UniProt Comments for ITGb2
ITGB2: the integrin beta 2 subunit. Can combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Participates in cell adhesion as well as cell-surface mediated signaling. Defects are the cause of leukocyte adhesion deficiency type I (LAD1).
Protein type: Cell adhesion; Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.
Chromosomal Location of Human Ortholog: 10 C1|10 39.72 cM
Cellular Component: cell surface; extracellular exosome; integral component of membrane; integrin alphaL-beta2 complex; integrin complex; membrane; membrane raft; plasma membrane; receptor complex
Molecular Function: amyloid-beta binding; cell adhesion molecule binding; complement component C3b binding; heat shock protein binding; ICAM-3 receptor activity; metal ion binding; protein binding; protein complex binding; protein heterodimerization activity; protein kinase binding; receptor activity
Biological Process: activated T cell proliferation; cell adhesion; cell-matrix adhesion; cellular extravasation; cellular response to low-density lipoprotein particle stimulus; endothelial cell migration; heterotypic cell-cell adhesion; integrin-mediated signaling pathway; leukocyte adhesion; leukocyte migration involved in inflammatory response; natural killer cell activation; neutrophil chemotaxis; neutrophil migration; phagocytosis; phagocytosis, engulfment; positive regulation of angiogenesis; positive regulation of neutrophil degranulation; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of superoxide anion generation; receptor clustering; receptor internalization; regulation of peptidyl-tyrosine phosphorylation
Research Articles on ITGb2
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-ITGb2 antibody
Pathways associated with anti-ITGb2 antibody
Diseases associated with anti-ITGb2 antibody
Organs/Tissues associated with anti-ITGb2 antibody
|