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anti-ITGA3 antibody :: Rabbit Integrin alpha 3 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS175637
Unit / Price
0.1 mg  /  $245 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Integrin alpha 3 (ITGA3), Polyclonal Antibody

★Popular Item★
 Also Known As   

Anti-Integrin alpha 3 antibody

 Product Synonym Names    Integrin alpha-3; integrin, alpha 3(antigen CD49C, alpha 3 subunit of VLA-3 receptor); AA407068 antibody; Antigen identified by monoclonal antibody J143 antibody; CD49 antigen like family member C antibody; CD49 antigen-like family member C antibody; CD49c antibody; CD49c antigen antibody; FLJ34631 antibody; FLJ34704 antibody; FRP 2 antibody; FRP-2 antibody; FRP2 antibody; galactoprotein B3 antibody; GAP B3 antibody; GAPB3 antibody; Integrin alpha 3 antibody; Integrin alpha-3 light chain antibody; Integrin, alpha 3(antigen CD49C, alpha 3 subunit of VLA-3 receptor) antibody; ITA3_HUMAN antibody; ITGA 3 antibody; ITGA3 antibody; MSK18 antibody; URO1 antibody; VCA 2 antibody; VCA2 antibody; Very late activation protein 3 receptor alpha 3 subunit antibody; Very Late Activation Protein 3 Receptor Alpha 3 Subunit antibody; VL3A antibody; VLA 3 alpha chain antibody; VLA 3 subunit alpha antibody; VLA-3 subunit alpha antibody; VLA3 antibody; VLA3a antibody
 Product Gene Name   

anti-ITGA3 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    gene 614748
 3D Structure    ModBase 3D Structure for P26006
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Purity/Purification    Immunogen affinity purified.
 Form/Format    Lyophilized
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 Immunogen    A synthetic peptide corresponding to a sequence at the N-terminus of human Integrin alpha 3 (51-67aa LFGYSVALHRQTERQQR), identical to the related rat and mouse sequences.
 Contents    Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
 Reconstitution    Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
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 Preparation and Storage    At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-ITGA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ITGA3 antibody

   Description: Rabbit IgG polyclonal antibody for Integrin alpha-3(ITGA3) detection. Tested with WB, IHC-P in Human, Mouse, Rat.
Background: ITGA3(INTEGRIN, ALPHA-3), also called CD49C, VLA3 or GAPB3, is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit which is also a member of the family of cell surface adhesion molecules. ITGA3 is mapped to chromosome 17 and its exact cytogenetic location is 17q21.33. ITGA3 makes up half of the alpha3beta1 integrin duplex that plays a role in neural migration and corticogenesis together with beta-1 subunit. A functional link between DAB1 phosphorylation and ITGA3 signaling drives the timely detachment of migrating neurons from radial glial fibers. Expression of human ITGA3 increased the infectivity of virus for Chinese hamster ovary cells. ITGA3 also contains 13 potential N-glycosylation sites, 2 potential cleavage sites, and the 7 N-terminal repeating units characteristic of ITGAs. Recombinant ITGA3 is expressed as a 150-kD protein as the same size as the native protein by the western blot analysis.
 Applications Tested/Suitable for anti-ITGA3 antibody   

Western Blot (WB), Immunohistochemistry (IHC) Paraffin

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 Western Blot (WB) of anti-ITGA3 antibody    Anti-Integrin alpha 3 antibody, MBS175637, Western blotting
Lane 1: Rat Heart Tissue Lysate
Lane 2: HELA Cell Lysate

anti-ITGA3 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-ITGA3 antibody    Anti-Integrin alpha 3 antibody, MBS175637, IHC(P)
IHC(P): Rat Brain Tissue
anti-ITGA3 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-ITGA3 antibody    Anti-Integrin alpha 3 antibody, MBS175637, IHC(P)
IHC(P): Human Intestinal Cancer Tissue
anti-ITGA3 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for ITGA3. It may not necessarily be applicable to this product.
 NCBI GI #    347595830
 NCBI GeneID    3675
 NCBI Accession #    P26006.5 [Other Products]
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 UniProt Primary Accession #    P26006 [Other Products]
 UniProt Secondary Accession #    A7E246; B7ZM80; B9EGQ1; D3DTX4; D3DTX5 [Other Products]
 UniProt Related Accession #    P26006 [Other Products]
 Molecular Weight    118,756 Da
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 NCBI Official Full Name    Integrin alpha-3
 NCBI Official Synonym Full Names    integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
 NCBI Official Symbol    ITGA3 [Similar Products]
 NCBI Official Synonym Symbols   
VL3A; CD49C; GAPB3; ILNEB; MSK18; VCA-2; VLA3a; GAP-B3
[Similar Products]
 NCBI Protein Information    integrin alpha-3; FRP-2; galactoprotein B3; VLA-3 subunit alpha; CD49 antigen-like family member C; antigen identified by monoclonal antibody J143; very late activation protein 3 receptor, alpha-3 subunit
 UniProt Protein Name    Integrin alpha-3
 UniProt Synonym Protein Names   
CD49 antigen-like family member C; FRP-2; Galactoprotein B3; GAPB3; VLA-3 subunit alpha; CD_antigen: CD49cCleaved into the following 2 chains:Integrin alpha-3 heavy chain; Integrin alpha-3 light chain
 Protein Family    Integrin
 UniProt Gene Name    ITGA3 [Similar Products]
 UniProt Synonym Gene Names    MSK18; GAPB3 [Similar Products]
 UniProt Entry Name    ITA3_HUMAN
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 NCBI Summary for ITGA3    The protein encoded by this gene belongs to the family of integrins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain, and function as cell surface adhesion molecules. This gene encodes alpha 3 subunit, which undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1 subunit to form an integrin that interacts with many extracellular-matrix proteins. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
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 UniProt Comments for ITGA3    ITGA3: an integral membrane protein that heterodimerizes with a beta chain, forming a receptor for many extracellular-matrix proteins including fibronectin, laminin, collagen, epiligrin and thrombospondin. Undergoes post-translational cleavage in the extracellular domain to yield disulfide-linked light and heavy chains that join with beta 1. Two alternatively spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Receptor, misc.; Cell adhesion; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17q21.33

Cellular Component: filopodium membrane; cell surface; focal adhesion; growth cone; basolateral plasma membrane; perinuclear region of cytoplasm; plasma membrane; excitatory synapse; integrin complex; receptor complex; external side of plasma membrane

Molecular Function: collagen binding; integrin binding; protein domain specific binding; protein binding; protease binding; protein heterodimerization activity; fibronectin binding; metal ion binding; laminin binding; glycoprotein binding

Biological Process: integrin-mediated signaling pathway; skin development; response to drug; extracellular matrix organization and biogenesis; maternal process involved in pregnancy; heart development; cell-matrix adhesion; regulation of BMP signaling pathway; neuron migration; regulation of Wnt receptor signaling pathway; mesodermal cell differentiation; memory; regulation of transforming growth factor beta receptor signaling pathway; negative regulation of Rho protein signal transduction; blood coagulation; leukocyte migration; negative regulation of cell projection organization and biogenesis; lung development

Disease: Interstitial Lung Disease, Nephrotic Syndrome, And Epidermolysis Bullosa, Congenital
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 Research Articles on ITGA3    1. Taken together, it was concluded that CD151 promotes the proliferation and migration of PC3 cells through the formation of CD151-integrin complex and the activation of phosphorylated ERK.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ITGA3 antibodyPathways associated with anti-ITGA3 antibody
 Reference Product  PubMed Publications
 ITGB1 antibody  >8 publications with ITGA3 and ITGB1
 ITGB4 antibody  >7 publications with ITGA3 and ITGB4
 ITGB5 antibody  >3 publications with ITGA3 and ITGB5
 LAMA5 antibody  >2 publications with ITGA3 and LAMA5
 FN1 antibody  >2 publications with ITGA3 and FN1
 LAMB3 antibody  >1 publications with ITGA3 and LAMB3
 VTN antibody  >1 publications with ITGA3 and VTN
 LAMA3 antibody  >1 publications with ITGA3 and LAMA3
 RELN antibody  >1 publications with ITGA3 and RELN
 Products by Pathway  Pathway Diagram
 Arf6 Trafficking Events Pathway antibodies  Arf6 Trafficking Events Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Basigin Interactions Pathway antibodies  Basigin Interactions Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
Diseases associated with anti-ITGA3 antibodyOrgans/Tissues associated with anti-ITGA3 antibody
 Disease Name  Pubmed Publications
 Lung Neoplasms Antibodies  >4 publications with ITGA3 and Lung Neoplasms
 Lung Diseases Antibodies  >4 publications with ITGA3 and Lung Diseases
 Nervous System Diseases Antibodies  >3 publications with ITGA3 and Nervous System Diseases
 Congenital Abnormalities Antibodies  >3 publications with ITGA3 and Congenital Abnormalities
 Kidney Diseases Antibodies  >3 publications with ITGA3 and Kidney Diseases
 Breast Neoplasms Antibodies  >3 publications with ITGA3 and Breast Neoplasms
 Cell Transformation, Neoplastic Antibodies  >2 publications with ITGA3 and Cell Transformation, Neoplastic
 Neoplasms, Experimental Antibodies  >1 publications with ITGA3 and Neoplasms, Experimental
 Proteinuria Antibodies  >1 publications with ITGA3 and Proteinuria
 Hyperplasia Antibodies  >1 publications with ITGA3 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >6 publications with ITGA3 and Lung
 Kidney Antibodies  >6 publications with ITGA3 and Kidney
 Embryonic Tissue Antibodies  >5 publications with ITGA3 and Embryonic Tissue
 Blood Antibodies  >5 publications with ITGA3 and Blood
 Skin Antibodies  >4 publications with ITGA3 and Skin
 Lymph Node Antibodies  >4 publications with ITGA3 and Lymph Node
 Nerve Antibodies  >3 publications with ITGA3 and Nerve
 Bone Antibodies  >3 publications with ITGA3 and Bone
 Brain Antibodies  >3 publications with ITGA3 and Brain
 Mouth Antibodies  >3 publications with ITGA3 and Mouth
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