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anti-ITGA4 antibody :: Rabbit Integrin alpha 4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS150329
Western Blot (WB)
Unit / Price
0.1 mg  /  $345 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Integrin alpha 4 (ITGA4), Polyclonal Antibody

 Also Known As   

Integrin alpha 4 Antibody

 Product Synonym Names    Integrin alpha 4; IA4; CD49D; Integrin alpha-4; CD49 antigen-like family member D; integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
 Product Gene Name   

anti-ITGA4 antibody

[Similar Products]
 Antibody/Peptide Pairs    Integrin alpha 4 peptide (MBS153211) is used for blocking the activity of Integrin alpha 4 antibody (MBS150329)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    192975
 3D Structure    ModBase 3D Structure for P13612
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human, Mouse, Rat
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 Specificity    At least two isoforms are known to exist. The immunogen to this antibody is outside of the Integrin alpha4 recombinant protein fragment and thus will not recognize it.
 Purity/Purification    Integrin alpha 4 Antibody is affinity chromatography purified via peptide column.
 Form/Format    Liquid
 Concentration    1 mg/mL (lot specific)
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 Conjugate    Unconjugated
 Immunogen    Integrin alpha 4 antibody was raised against a 13 amino acid synthetic peptide from near the carboxy terminus of human Integrin alpha 4.
 Buffer    Integrin alpha 4 Antibody is supplied in PBS containing 0.02% sodium azide.
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 Preparation and Storage    Integrin alpha 4 antibody can be stored at 4 degree C for three months and -20 degree C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
 Other Notes    Small volumes of anti-ITGA4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Product Description specifically for anti-ITGA4 antibody

   Integrin alpha 4 Antibody: The integrin alpha 4 (also known as CD49d and ITGA4) belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha and beta chains. Alpha4 chain associates with either beta1 or beta7 chain. It has been demonstrated that the putative ligand-binding sites of both integrin alpha4beta1 and alpha4beta7 is located on the alpha4 chain. These ligands included Madcam, VCAM, and fibronectin. Madcam is known as the principal ligand for integrin alpha4beta7. Recently it was also demonstrated that HIV-1 envelope can mimic Madcam by binding to and signaling though integrin alpha4beta7, the gut mucosal homing receptor for peripheral T cells.
 Applications Tested/Suitable for anti-ITGA4 antibody   

ELISA (EIA), Western Blot (WB)

 Application Notes for anti-ITGA4 antibody    Integrin alpha 4 antibody can be used for the detection of Integrin alpha 4 by Western blot at 1 mug/mL. Despite its predicted molecular weight, Integrin alpha4 will often run at higher molecular weight in SDS-PAGE.
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 Western Blot (WB) of anti-ITGA4 antibody    Western blot analysis of Integrin alpha 4 in Jurkat cell lysate with Integrin alpha 4 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
anti-ITGA4 antibody Western Blot (WB) (WB) image
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NCBI/Uniprot data below describe general gene information for ITGA4. It may not necessarily be applicable to this product.
 NCBI GI #    67191027
 NCBI GeneID    3676
 NCBI Accession #    NP_000876 [Other Products]
 NCBI GenBank Nucleotide #    NM_000885.4 [Other Products]
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 UniProt Primary Accession #    P13612 [Other Products]
 UniProt Secondary Accession #    Q7Z4L6; D3DPG4 [Other Products]
 UniProt Related Accession #    P13612; AAB25486 [Other Products]
 Molecular Weight    21,536 Da
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 NCBI Official Full Name    integrin alpha-4
 NCBI Official Synonym Full Names    integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
 NCBI Official Symbol    ITGA4 [Similar Products]
 NCBI Official Synonym Symbols   
IA4; CD49D
[Similar Products]
 NCBI Protein Information    integrin alpha-4; 269C wild type; integrin alpha 4; integrin alpha-IV; VLA-4 subunit alpha; integrin alpha-4 subunit; CD49 antigen-like family member D; antigen CD49D, alpha-4 subunit of VLA-4 receptor; very late activation protein 4 receptor, alpha 4 subunit
 UniProt Protein Name    Integrin alpha-4
 UniProt Synonym Protein Names   
CD49 antigen-like family member D; Integrin alpha-IV; VLA-4 subunit alpha; CD_antigen: CD49d
 Protein Family    Integrin
 UniProt Gene Name    ITGA4 [Similar Products]
 UniProt Synonym Gene Names    CD49D [Similar Products]
 UniProt Entry Name    ITA4_HUMAN
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 NCBI Summary for ITGA4    The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain. [provided by RefSeq, Jul 2008]
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 UniProt Comments for ITGA4    ITGA4: Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin. They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. They are also receptors for VCAM1. Integrin alpha- 4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha- 4/beta-7 is also a receptor for MADCAM1. It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells. Heterodimer of an alpha and a beta subunit. The alpha subunit can sometimes be cleaved into two non-covalently associated fragments. Alpha-4 associates with either beta-1 or beta-7. Alpha-4 interacts with PXN, LPXN, and TGFB1I1/HIC5. Interacts with CSPG4 through CSPG4 chondroitin sulfate glycosaminoglycan. Belongs to the integrin alpha chain family.

Protein type: Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.; Cell adhesion

Chromosomal Location of Human Ortholog: 2q31.3

Cellular Component: focal adhesion; cell surface; membrane; plasma membrane; intercellular junction; external side of plasma membrane

Molecular Function: protein binding; metal ion binding; fibronectin binding; cell adhesion molecule binding

Biological Process: integrin-mediated signaling pathway; regulation of immune response; extracellular matrix organization and biogenesis; cell-matrix adhesion; heart development; receptor clustering; heterophilic cell adhesion; heterotypic cell-cell adhesion; leukocyte adhesion; B cell differentiation; blood vessel remodeling; leukocyte tethering or rolling; blood coagulation; leukocyte migration
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 Research Articles on ITGA4    1. LFA-1 and CR4 alpha chain phosphorylation is needed for chemokine-induced cross-talk to VLA-4
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products related to Integrin alpha 4 Antibody
 Catalog #  Product Name  Catalog #  Product Name
 MBS086956  Monkey Integrin Alpha 4 ELISA Kit  MBS075999  Camel Integrin Alpha 4 ELISA Kit
 MBS071761  Mouse Integrin Alpha 4 ELISA Kit  MBS673624  Rat Anti-Mouse LPAM-1-PE
 MBS094285  Rabbit Integrin Alpha 4 ELISA Kit  MBS150329  Integrin alpha 4 Antibody
 MBS9410064  Integrin alpha 4 Antibody  MBS105645  Porcine Integrin Alpha 4 ELISA Kit
 MBS102439  Fish Integrin Alpha 4 ELISA Kit  MBS673625  Rat Anti-Mouse LPAM-1-LE/AF
Products associated with anti-ITGA4 antibodyPathways associated with anti-ITGA4 antibody
 Reference Product  PubMed Publications
 MADCAM1 antibody  >49 publications with ITGA4 and MADCAM1
 PXN antibody  >15 publications with ITGA4 and PXN
 ITGB1 antibody  >12 publications with ITGA4 and ITGB1
 VCAM1 antibody  >10 publications with ITGA4 and VCAM1
 ITGB7 antibody  >3 publications with ITGA4 and ITGB7
 CD81 antibody  >2 publications with ITGA4 and CD81
 FN1 antibody  >2 publications with ITGA4 and FN1
 ADAM28 antibody  >1 publications with ITGA4 and ADAM28
 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
Diseases associated with anti-ITGA4 antibodyOrgans/Tissues associated with anti-ITGA4 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >245 publications with ITGA4 and Inflammation
 Demyelinating Diseases Antibodies  >187 publications with ITGA4 and Demyelinating Diseases
 Disease Models, Animal Antibodies  >134 publications with ITGA4 and Disease Models, Animal
 Necrosis Antibodies  >119 publications with ITGA4 and Necrosis
 Lung Diseases Antibodies  >56 publications with ITGA4 and Lung Diseases
 Leukemia, Lymphocytic, Chronic, B-Cell Antibodies  >34 publications with ITGA4 and Leukemia, Lymphocytic, Chronic, B-Cell
 Atherosclerosis Antibodies  >21 publications with ITGA4 and Atherosclerosis
 Lung Neoplasms Antibodies  >19 publications with ITGA4 and Lung Neoplasms
 Liver Diseases Antibodies  >18 publications with ITGA4 and Liver Diseases
 Fibrosis Antibodies  >18 publications with ITGA4 and Fibrosis
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >844 publications with ITGA4 and Blood
 Vascular Antibodies  >475 publications with ITGA4 and Vascular
 Bone Antibodies  >195 publications with ITGA4 and Bone
 Bone Marrow Antibodies  >169 publications with ITGA4 and Bone Marrow
 Brain Antibodies  >125 publications with ITGA4 and Brain
 Lung Antibodies  >103 publications with ITGA4 and Lung
 Embryonic Tissue Antibodies  >89 publications with ITGA4 and Embryonic Tissue
 Lymph Antibodies  >84 publications with ITGA4 and Lymph
 Lymph Node Antibodies  >84 publications with ITGA4 and Lymph Node
 Muscle Antibodies  >76 publications with ITGA4 and Muscle
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