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anti-ITGA8 antibody :: Goat anti-Mouse Integrin alpha8 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS616970 anti-ITGA8 antibody
Unit / Price
0.1 mg  /  $765 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Integrin alpha8 (ITGA8), Polyclonal Antibody

 Also Known As   

Integrin alpha8

 Product Synonym Names    Anti -Integrin alpha8
 Product Gene Name   

anti-ITGA8 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 10; NC_000010.10 (15559088..15761770, complement). Location: 10p13
 OMIM    604063
 3D Structure    ModBase 3D Structure for P53708
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Goat
 Species Reactivity    Mouse
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 Specificity    Recognizes mouse Integrin alpha8. Shows <1% crossreactivity with recombinant human and mouse Integrin alpha5 and recombinant human and mouse Integrin alphaV in direct ELISA and Western Blot. Species Sequence Homology: rat (96%), human (90%).
 Purity/Purification    Affinity Purified
Purified by immunoaffinity chromatography.
 Form/Format    Supplied as a lyophilized powder from PBS, pH 7.4, 5% trehalose. Reconstitute with 500ul sterile PBS.
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 Immunogen    Recombinant corresponding to Phe38-Phe1007 from mouse Integrin alpha8, expressed in CHO cells (NP_001001309).
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 Preparation and Storage    Lyophilized powder may be stored at -20 degree C. Stable for 12 months at -20 degree C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Reconstituted product is stable for 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. 
 Other Notes    Small volumes of anti-ITGA8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-ITGA8 antibody

   Integrin alpha8 is a 170-200kD member of the integrin family of adhesion molecules. It forms an exclusive noncovalent heterodimer with integrin beta-1. Alpha-8/beta-1 romotes both cell adhesion and survival and is known to bind to fibronectin, the latency-associated peptide in latent TGF-beta 1 and nephronectin. Mouse integrin alpha-8 is a 1025aa type I transmembrane glycoprotein. It contains a 969aa extracellular region (aa38-1006) and a 29aa cytoplasmic domain. One isoform may exist that shows a truncation after Ala675 of the precursor. In the ECD, mouse Integrin alpha8 shares 96% and 90% aa sequence identity with rat and human Integrin alpha-8 protein, respectively.
 Product Categories/Family for anti-ITGA8 antibody    Antibodies; Abs to Integrin
 Applications Tested/Suitable for anti-ITGA8 antibody   

ELISA (EL/EIA), Western Blot (WB), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)

 Application Notes for anti-ITGA8 antibody    Suitable for use in Western Blot, Immunocytochemistry, Flow Cytometry and Direct ELISA.
Dilution: Western Blot: 0.1ug/ml
Immunocytochemistry: 5-15ug/ml used to detect Integrin alpha8 in immersion fixed 4T1 mouse mammary carcinoma cells.
Flow Cytometry: 2.5ug labels 10e6 4T1 mouse mammary carcinoma cells.
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NCBI/Uniprot data below describe general gene information for ITGA8. It may not necessarily be applicable to this product.
 NCBI GI #    49170034
 NCBI GeneID    8516
 NCBI Accession #    NP_003629.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_003638.1 [Other Products]
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 UniProt Primary Accession #    P53708 [Other Products]
 UniProt Secondary Accession #    Q5VX94; B0YJ31 [Other Products]
 UniProt Related Accession #    P53708 [Other Products]
 Molecular Weight    117,474 Da [Similar Products]
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 NCBI Official Full Name    integrin alpha-8
 NCBI Official Synonym Full Names    integrin, alpha 8
 NCBI Official Symbol    ITGA8 [Similar Products]
 NCBI Official Synonym Symbols   
ITGA8
[Similar Products]
 NCBI Protein Information    integrin alpha-8; OTTHUMP00000019207
 UniProt Protein Name    Integrin alpha-8
 Protein Family    Integrin
 UniProt Gene Name    ITGA8 [Similar Products]
 UniProt Entry Name    ITA8_HUMAN
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 NCBI Summary for ITGA8    Integrins are heterodimeric transmembrane receptor proteins that mediate numerous cellular processes including cell adhesion, cytoskeletal rearrangement, and activation of cell signaling pathways. Integrins are composed of alpha and beta subunits. This gene encodes the alpha 8 subunit of the heterodimeric integrin alpha8beta1 protein. The encoded protein is a single-pass type 1 membrane protein that contains multiple FG-GAP repeats. This repeat is predicted to fold into a beta propeller structure. This gene regulates the recruitment of mesenchymal cells into epithelial structures, mediates cell-cell interactions, and regulates neurite outgrowth of sensory and motor neurons. The integrin alpha8beta1 protein thus plays an important role in wound-healing and organogenesis. Mutations in this gene have been associated with renal hypodysplasia/aplasia-1 (RHDA1) and with several animal models of chronic kidney disease. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Apr 2014]
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 UniProt Comments for ITGA8    ITGA8: Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons. Belongs to the integrin alpha chain family.

Protein type: Membrane protein, integral; Cell adhesion; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10p13

Cellular Component: cell surface; focal adhesion; apical part of cell; endoplasmic reticulum; postsynaptic density; plasma membrane; perikaryon; integrin complex

Molecular Function: metal ion binding

Biological Process: integrin-mediated signaling pathway; extracellular matrix organization and biogenesis; inner ear morphogenesis; cell-matrix adhesion; positive regulation of transforming growth factor beta receptor signaling pathway; mesodermal cell differentiation; memory; smooth muscle development; establishment of protein localization; cell-cell adhesion; cell projection organization and biogenesis; brain development; kidney development; metanephros development

Disease: Renal Hypodysplasia/aplasia 1
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 Research Articles on ITGA8    1. alpha8beta1 is a prerequisite for the proper conduct of anoikis in normal human intestinal epithelial crypt cells, whereas its loss contributes to the illicit acquisition of anoikis resistance.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-ITGA8 antibodyPathways associated with anti-ITGA8 antibody
 Reference Product  PubMed Publications
 FN1 antibody  >1 publications with ITGA8 and FN1
 ITGB1 antibody  >1 publications with ITGA8 and ITGB1
 Products by Pathway  Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway antibodies  Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 Dilated Cardiomyopathy Pathway antibodies  Dilated Cardiomyopathy Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 ECM-receptor Interaction Pathway antibodies  ECM-receptor Interaction Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram
Diseases associated with anti-ITGA8 antibodyOrgans/Tissues associated with anti-ITGA8 antibody
 Disease Name  Pubmed Publications
 Kidney Diseases Antibodies  >2 publications with ITGA8 and Kidney Diseases
 Hypertension Antibodies  >2 publications with ITGA8 and Hypertension
 Cardiovascular Diseases Antibodies  >2 publications with ITGA8 and Cardiovascular Diseases
 Fibrosis Antibodies  >1 publications with ITGA8 and Fibrosis
 Vascular Diseases Antibodies  >1 publications with ITGA8 and Vascular Diseases
 Neurologic Manifestations Antibodies  >1 publications with ITGA8 and Neurologic Manifestations
 Atherosclerosis Antibodies  >1 publications with ITGA8 and Atherosclerosis
 Ovarian Neoplasms Antibodies  >1 publications with ITGA8 and Ovarian Neoplasms
 Organ/Tissue Name  Pubmed Publications
 Kidney Antibodies  >3 publications with ITGA8 and Kidney
 Muscle Antibodies  >2 publications with ITGA8 and Muscle
 Vascular Antibodies  >2 publications with ITGA8 and Vascular
 Lung Antibodies  >2 publications with ITGA8 and Lung
 Eye Antibodies  >1 publications with ITGA8 and Eye
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