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anti-IFNa/bR1 antibody :: Rabbit anti-Rat Interferon Alpha/Beta Receptor 1 (IFNa/bR1) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2013291 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Western Blot
Unit / Price
0.1 mg  /  $400 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interferon Alpha/Beta Receptor 1 (IFNa/bR1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Biotin-Linked Antibody to Interferon Alpha/Beta Receptor 1 (IFNa/bR1)

 Product Gene Name   

anti-IFNa/bR1 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 21; NC_000021.8 (34696748..34732129). Location: 21q22.11
 OMIM    107450
 3D Structure    ModBase 3D Structure for P17181
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Rat
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 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3, 50% glycerol
 Concentration    200ug/ml (lot specific)
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 Immunogen    IFNa/bR1, Rat
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 Other Notes    Small volumes of anti-IFNa/bR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-IFNa/bR1 antibody    Biotin Antibody
 Applications Tested/Suitable for anti-IFNa/bR1 antibody   

Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC) Formalin/Paraffin, ELISA (EIA)

 Application Notes for anti-IFNa/bR1 antibody    Western Blot: 1:50-400
Immunocytochemistry in formalin fixed cells: 1:50-500
Immunohistochemistry in formalin fixed frozen section: 1:50-500
Immunohistochemistry in paraffin section: 1:10-100
ELISA: 1:100-5000
Optimal working dilutions must be determined by end user.
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 Western Blot of anti-IFNa/bR1 antibody    Used in Western Blot, Sample: Recombinant IFNa/bR1, Rat
anti-IFNa/bR1 antibody Western Blot (WB) image
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NCBI/Uniprot data below describe general gene information for IFNa/bR1. It may not necessarily be applicable to this product.
 NCBI GI #    46488932
 NCBI GeneID    3454
 NCBI Accession #    NP_000620.2 [Other Products]
 NCBI GenBank Nucleotide #    NM_000629.2 [Other Products]
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 UniProt Primary Accession #    P17181 [Other Products]
 UniProt Secondary Accession #    Q53GW9; Q53H11; Q6PKD7; Q7M4L2; Q8WTZ2; B2R6L9; D3DSF0 [Other Products]
 UniProt Related Accession #    P17181 [Other Products]
 Molecular Weight    63,525 Da
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 NCBI Official Full Name    interferon alpha/beta receptor 1
 NCBI Official Synonym Full Names    interferon (alpha, beta and omega) receptor 1
 NCBI Official Symbol    IFNAR1 [Similar Products]
 NCBI Official Synonym Symbols   
AVP; IFRC; IFNAR; IFNBR; IFN-alpha-REC
[Similar Products]
 NCBI Protein Information    interferon alpha/beta receptor 1; CRF2-1; IFN-R-1; IFN-alpha/beta receptor 1; interferon-beta receptor 1; beta-type antiviral protein; alpha-type antiviral protein; type I interferon receptor 1; cytokine receptor class-II member 1; cytokine receptor family 2 member 1; interferon-alpha/beta receptor alpha chain
 UniProt Protein Name    Interferon alpha/beta receptor 1
 UniProt Synonym Protein Names   
Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; CRF2-1; Type I interferon receptor 1
 UniProt Gene Name    IFNAR1 [Similar Products]
 UniProt Synonym Gene Names    IFNAR; IFN-R-1; IFN-alpha/beta receptor 1; CRF2-1 [Similar Products]
 UniProt Entry Name    INAR1_HUMAN
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 NCBI Summary for IFNa/bR1    The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The encoded protein also functions as an antiviral factor. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IFNa/bR1    IFNAR1: receptor for interferons alpha and beta. Belongs to the type II cytokine family of receptors. Binding to type I IFNs triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and IFNR alpha- and beta-subunits themselves. Tyk2 tyrosine kinase is essential for stable cell surface expression of IFNAR1. Present in all tissues and even on the surface of most IFN-resistant cells.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: interferon receptor activity; protein binding; interferon-alpha/beta receptor activity

Biological Process: positive regulation of interferon-gamma production; cell surface receptor linked signal transduction; T cell activation; cytokine and chemokine mediated signaling pathway; response to virus; positive regulation of interleukin-1 beta secretion; interferon type I biosynthetic process; JAK-STAT cascade; defense response to virus
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 Research Articles on IFNa/bR1    1. [review] The type I interferon system has an important role in the pathogenesis of Sjogren's syndrome.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IFNa/bR1 antibodyPathways associated with anti-IFNa/bR1 antibody
 Reference Product  PubMed Publications
 IFNA2 antibody  >342 publications with IFNa/bR1 and IFNA2
 IFNAR2 antibody  >138 publications with IFNa/bR1 and IFNAR2
 TYK2 antibody  >50 publications with IFNa/bR1 and TYK2
 STAT2 antibody  >48 publications with IFNa/bR1 and STAT2
 JAK1 antibody  >35 publications with IFNa/bR1 and JAK1
 STAT3 antibody  >17 publications with IFNa/bR1 and STAT3
 SOCS1 antibody  >14 publications with IFNa/bR1 and SOCS1
 IFNB1 antibody  >4 publications with IFNa/bR1 and IFNB1
 Products by Pathway  Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Downstream Signaling In Naive CD8+ T Cells Pathway antibodies  Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
 Hepatitis B Pathway antibodies  Hepatitis B Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Hepatitis C Pathway antibodies  Hepatitis C Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Herpes Simplex Infection Pathway antibodies  Herpes Simplex Infection Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
Diseases associated with anti-IFNa/bR1 antibodyOrgans/Tissues associated with anti-IFNa/bR1 antibody
 Disease Name  Pubmed Publications
 Virus Diseases Antibodies  >87 publications with IFNa/bR1 and Virus Diseases
 Neoplasms Antibodies  >48 publications with IFNa/bR1 and Neoplasms
 Inflammation Antibodies  >46 publications with IFNa/bR1 and Inflammation
 Liver Diseases Antibodies  >43 publications with IFNa/bR1 and Liver Diseases
 Necrosis Antibodies  >22 publications with IFNa/bR1 and Necrosis
 Carcinoma, Hepatocellular Antibodies  >12 publications with IFNa/bR1 and Carcinoma, Hepatocellular
 Cardiovascular Diseases Antibodies  >7 publications with IFNa/bR1 and Cardiovascular Diseases
 Fever Antibodies  >5 publications with IFNa/bR1 and Fever
 Kidney Diseases Antibodies  >5 publications with IFNa/bR1 and Kidney Diseases
 Heart Diseases Antibodies  >4 publications with IFNa/bR1 and Heart Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >104 publications with IFNa/bR1 and Blood
 Liver Antibodies  >42 publications with IFNa/bR1 and Liver
 Bone Antibodies  >34 publications with IFNa/bR1 and Bone
 Bone Marrow Antibodies  >32 publications with IFNa/bR1 and Bone Marrow
 Lung Antibodies  >25 publications with IFNa/bR1 and Lung
 Spleen Antibodies  >19 publications with IFNa/bR1 and Spleen
 Brain Antibodies  >19 publications with IFNa/bR1 and Brain
 Lymph Node Antibodies  >11 publications with IFNa/bR1 and Lymph Node
 Lymph Antibodies  >11 publications with IFNa/bR1 and Lymph
 Skin Antibodies  >10 publications with IFNa/bR1 and Skin
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