NP_002167.1
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NCBI GenBank Nucleotide #
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
22,294 Da
NCBI Official Full Name
interferon beta
NCBI Official Synonym Full Names
interferon beta 1
NCBI Protein Information
interferon beta
UniProt Protein Name
Interferon beta
UniProt Synonym Protein Names
Fibroblast interferon
UniProt Synonym Gene Names
NCBI Summary for IFNb
This gene encodes a cytokine that belongs to the interferon family of signaling proteins, which are released as part of the innate immune response to pathogens. The protein encoded by this gene belongs to the type I class of interferons, which are important for defense against viral infections. In addition, type I interferons are involved in cell differentiation and anti-tumor defenses. Following secretion in response to a pathogen, type I interferons bind a homologous receptor complex and induce transcription of genes such as those encoding inflammatory cytokines and chemokines. Overactivation of type I interferon secretion is linked to autoimmune diseases. Mice deficient for this gene display several phenotypes including defects in B cell maturation and increased susceptibility to viral infection. [provided by RefSeq, Sep 2015]
UniProt Comments for IFNb
IFNB1: Has antiviral, antibacterial and anticancer activities. Belongs to the alpha/beta interferon family.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 9p21.3
Cellular Component: extracellular region; extracellular space
Molecular Function: chloramphenicol O-acetyltransferase activity; cytokine activity; interferon-alpha/beta receptor binding
Biological Process: adaptive immune response; B cell activation involved in immune response; B cell differentiation; B cell proliferation; blood coagulation; cell surface receptor signaling pathway; defense response to bacterium; defense response to virus; humoral immune response; macrophage activation involved in immune response; natural killer cell activation; natural killer cell activation involved in immune response; negative regulation of T cell differentiation; negative regulation of viral genome replication; positive regulation of innate immune response; positive regulation of peptidyl-serine phosphorylation of STAT protein; positive regulation of transcription from RNA polymerase II promoter; regulation of MHC class I biosynthetic process; response to exogenous dsRNA; response to virus; T cell activation involved in immune response
Research Articles on IFNb
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Products associated with anti-IFNb antibody
Pathways associated with anti-IFNb antibody
Diseases associated with anti-IFNb antibody
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