Q8R460.1
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UniProt Primary Accession #
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UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Interleukin-36 gamma
NCBI Official Synonym Full Names
interleukin 1 family, member 9
NCBI Official Synonym Symbols
NCBI Protein Information
interleukin-36 gamma
UniProt Protein Name
Interleukin-36 gamma
UniProt Synonym Protein Names
Interleukin-1 family member 9; IL-1F9
UniProt Synonym Gene Names
UniProt Comments for IL1F9
Functions as an agonist of NF-kappa B activation through the orphan IL-1-receptor-related protein 2/IL1RL2. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor IL1RAP (). Seems to be involved in skin inflammatory response by acting on keratinocytes, dendritic cells and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. May play a role in proinflammatory responses during particular neutrophilic airway inflammation. May be involved in the innate immune response to fungal pathogens. Induces the production of proinflammatory cytokines in bone marrow-derived dendritic cells (BMDCs), including IL-12, Il-1 beta, IL-6, TNF-alpha and IL-23. Involved in dendritic cell maturation by stimulating the surface expression of CD80, CD86 and MHC class II. Induces the production of IFN-gamma, IL-4 and IL-17 by cultured CD4+ T-cells and splenocytes.
Research Articles on IL1F9
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Pathways associated with anti-IL1F9 antibody
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