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anti-IL1R1 antibody :: Rabbit anti-Human Interleukin 1 Receptor Type I (IL1R1) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2005592 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment)
Unit / Price
0.01 mg  /  $105 +1 FREE 8GB USB
0.02 mg  /  $125 +1 FREE 8GB USB
0.05 mg  /  $165 +1 FREE 8GB USB
0.1 mg  /  $210 +1 FREE 8GB USB
0.2 mg  /  $310 +1 FREE 8GB USB
1 mg  /  $725 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin 1 Receptor Type I (IL1R1), Polyclonal Antibody

★Popular Item★
 Also Known As   

Polyclonal Antibody to Interleukin 1 Receptor Type I (IL1R1)

 Product Gene Name   

anti-IL1R1 antibody

[Similar Products]
 Matching Pairs    Unconjugated Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2005592)
Biotin Conjugated Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2002084)
 Matching Pairs    Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2005592)
Antigen: Interleukin 1 Receptor Type I (IL1R1) (MBS2009303)
 Matching Pairs    Unconjugated Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2005592)
APC-CY7 Conjugated Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2036587)
 Matching Pairs    Unconjugated Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2005592)
PE Conjugated Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2036590)
 Matching Pairs    Unconjugated Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2005592)
APC-CY7 Conjugated Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2036593)
 Matching Pairs    Unconjugated Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2005592)
Cy3 Conjugated Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2036596)
 Matching Pairs    Unconjugated Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2005592)
FITC Conjugated Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2036599)
 Matching Pairs    Unconjugated Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2005592)
HRP Conjugated Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2036602)
 Matching Pairs    Unconjugated Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2005592)
APC-CY7 Conjugated Secondary Antibody: Immunoglobulin G (MBS2090675)
 Matching Pairs    Unconjugated Antibody: Interleukin 1 Receptor Type I (IL1R1) (MBS2005592)
Unconjugated Secondary Antibody: Immunoglobulin G (MBS2090678)
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Immunogen Sequence    Antigen: The target protein is fused with N-terminal His-Tag and its sequence is listed below.
MGHHHHHHSG SEF-DKCKER EEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKI
 OMIM    X16896 mRNA
 3D Structure    ModBase 3D Structure for P14778
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Specificity    The antibody is a rabbit polyclonal antibody raised against IL1R1. It has been selected for its ability to recognize IL1R1 in immunohistochemical staining andwestern blotting.
 Purity/Purification    Affinity Chromatography
 Form/Format    Supplied as solution form in PBS, pH7.4, containing 0.02% NaN3,50% glycerol.
 Concentration    200ug/ml (lot specific)
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 Immunogen    Recombinant IL1R1 (Asp21~Ile109) expressed in E.coli.
 Conjugated Antibody    The APC conjugated antibody version of this item is also available as catalog #MBS2036593
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 Preparation and Storage    Store at 4 degree C for frequent use. Stored at -20 degree C to -80 degree C in a manual defrost freezer for one year without detectable loss of activity. Avoid repeated freeze-thaw cycles.
 ISO Certification    Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
 Supply Chain Verification    Manufactured in a lab with traceable raw materials manufactured on site. Coordinated product portfolio of antibodies, pairs, conjugates, recombinant proteins, and immunoassay materials available. Please inquire.
 Other Notes    Small volumes of anti-IL1R1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-IL1R1 antibody    Knock-Out Validation Antibody
 Applications Tested/Suitable for anti-IL1R1 antibody   

Immunocytochemistry (ICC), Immunohistochemistry (IHC) - Formalin/Paraffin, ELISA (EIA), Western Blot (WB)

 Application Notes for anti-IL1R1 antibody    Western blotting: 1:100-400
Immunocytochemistry in formalin fixed cells: 1:100-500
Immunohistochemistry in formalin fixed frozen section: 1:100-500
Immunohistochemistry in paraffin section: 1:50-200
Enzyme-linked Immunosorbent Assay: 1:100-200
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 Western Blot (WB) Knockout Verification of anti-IL1R1 antibody    Knockout Verification: Lane 1: Wild-type Raji cell lysate; Lane 2: IL1R1 knockout Raji cell lysate; Predicted MW: 65kd Observed MW: 65kd Primary Ab: 3ug/ml Rabbit Anti-Human IL1R1 Antibody Second Ab: 0.2ug/mL HRP-Linked Caprine Anti-Rabbit IgG Polyclonal Antibody
anti-IL1R1 antibody Western Blot (WB) Knockout Verification (WB) image
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 Western Blot (WB) of anti-IL1R1 antibody    Western Blot; Sample: Human Raji Cells.
anti-IL1R1 antibody Western Blot (WB) (WB) image
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 Western Blot (WB) of anti-IL1R1 antibody    Western Blot; Sample: Recombinant IL1R1, Human.
anti-IL1R1 antibody Western Blot (WB) (WB) image
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 Immunohistochemistry (IHC) of anti-IL1R1 antibody    DAB staining on IHC-P; Samples: Human Liver Tissue.
anti-IL1R1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-IL1R1 antibody    DAB staining on IHC-P; Samples: Human Stomach Tissue
anti-IL1R1 antibody Immunohistochemistry (IHC) (IHC) image
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 Immunohistochemistry (IHC) of anti-IL1R1 antibody    DAB staining on IHC-P; Samples: Human Thyroid Cancer Tissue
anti-IL1R1 antibody Immunohistochemistry (IHC) (IHC) image
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NCBI/Uniprot data below describe general gene information for IL1R1. It may not necessarily be applicable to this product.
 NCBI GI #    4504659
 NCBI GeneID    3554
 NCBI Accession #    NP_000868.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_000877.3 [Other Products]
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 UniProt Primary Accession #    P14778 [Other Products]
 UniProt Secondary Accession #    Q587I7 [Other Products]
 UniProt Related Accession #    P14778 [Other Products]
 Molecular Weight    65,402 Da
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 NCBI Official Full Name    interleukin-1 receptor type 1 isoform 1
 NCBI Official Synonym Full Names    interleukin 1 receptor type 1
 NCBI Official Symbol    IL1R1 [Similar Products]
 NCBI Official Synonym Symbols   
P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha
[Similar Products]
 NCBI Protein Information    interleukin-1 receptor type 1
 UniProt Protein Name    Interleukin-1 receptor type 1
 UniProt Synonym Protein Names   
CD121 antigen-like family member A; Interleukin-1 receptor alpha; IL-1R-alpha
 Protein Family    Interleukin-1 receptor
 UniProt Gene Name    IL1R1 [Similar Products]
 UniProt Synonym Gene Names    IL1R; IL1RA; IL1RT1; IL-1R-1; IL-1RT-1; IL-1RT1; IL-1R-alpha; mIL-1R1; mIL-1RI; sIL-1R1; sIL-1RI [Similar Products]
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 NCBI Summary for IL1R1    This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
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 UniProt Comments for IL1R1    IL-1RA: Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex. Belongs to the interleukin-1 receptor family.

Protein type: EC 2.7.11.25; Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 2q11.2-q12.1

Cellular Component: external side of plasma membrane; extracellular region; integral component of plasma membrane; intracellular membrane-bound organelle; membrane; plasma membrane

Molecular Function: interleukin-1 binding; interleukin-1 receptor activity; interleukin-1, Type I, activating receptor activity; platelet-derived growth factor receptor binding; protease binding; protein binding; signal transducer activity; transmembrane receptor activity

Biological Process: cell surface receptor signaling pathway; immune response; positive regulation of interleukin-1-mediated signaling pathway; positive regulation of neutrophil extravasation; regulation of inflammatory response
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 Research Articles on IL1R1    1. Serum ST2 is elevated in heart failure patients and correlated with disease severity.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL1R1 antibodyPathways associated with anti-IL1R1 antibody
 Reference Product  PubMed Publications
 IL1B antibody  >32 publications with IL1R1 and IL1B
 IL1RN antibody  >16 publications with IL1R1 and IL1RN
 IL1A antibody  >13 publications with IL1R1 and IL1A
 MYD88 antibody  >6 publications with IL1R1 and MYD88
 IL1RAP antibody  >3 publications with IL1R1 and IL1RAP
 IRAK2 antibody  >2 publications with IL1R1 and IRAK2
 TRAF6 antibody  >2 publications with IL1R1 and TRAF6
 TICAM2 antibody  >1 publications with IL1R1 and TICAM2
 IRAK1 antibody  >1 publications with IL1R1 and IRAK1
 Products by Pathway  Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram
Diseases associated with anti-IL1R1 antibodyOrgans/Tissues associated with anti-IL1R1 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >37 publications with IL1R1 and Inflammation
 Necrosis Antibodies  >25 publications with IL1R1 and Necrosis
 Immune System Diseases Antibodies  >13 publications with IL1R1 and Immune System Diseases
 Nervous System Diseases Antibodies  >10 publications with IL1R1 and Nervous System Diseases
 Neoplasms Antibodies  >10 publications with IL1R1 and Neoplasms
 Cardiovascular Diseases Antibodies  >7 publications with IL1R1 and Cardiovascular Diseases
 Endometriosis Antibodies  >4 publications with IL1R1 and Endometriosis
 Lung Diseases Antibodies  >4 publications with IL1R1 and Lung Diseases
 Liver Diseases Antibodies  >3 publications with IL1R1 and Liver Diseases
 Hyperplasia Antibodies  >3 publications with IL1R1 and Hyperplasia
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >32 publications with IL1R1 and Blood
 Brain Antibodies  >11 publications with IL1R1 and Brain
 Vascular Antibodies  >8 publications with IL1R1 and Vascular
 Lung Antibodies  >8 publications with IL1R1 and Lung
 Uterus Antibodies  >7 publications with IL1R1 and Uterus
 Liver Antibodies  >6 publications with IL1R1 and Liver
 Heart Antibodies  >5 publications with IL1R1 and Heart
 Bone Antibodies  >5 publications with IL1R1 and Bone
 Muscle Antibodies  >5 publications with IL1R1 and Muscle
 Skin Antibodies  >5 publications with IL1R1 and Skin
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