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anti-IRAK4 antibody :: Rabbit anti-Human Interleukin-1 receptor-associated kinase 4 Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS1499083 anti-IRAK4 antibody
Unit / Price
0.05 mL  /  $120 +1 FREE 8GB USB
0.1 mL  /  $160 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin-1 receptor-associated kinase 4 (IRAK4), Polyclonal Antibody

 Also Known As   

Rabbit anti-human Interleukin-1 receptor-associated kinase 4 polyclonal Antibody(IRAK4)

 Product Synonym Names    IRAK-4; Renal carcinoma antigen NY-REN-64; IRAK4
 Product Gene Name   

anti-IRAK4 antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 OMIM    606883
 3D Structure    ModBase 3D Structure for Q9NWZ3
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 Clonality    Polyclonal
 Isotype    IgG
 Host    Rabbit
 Species Reactivity    Human
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 Purity/Purification    Antigen Affinity Purified
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 Storage Buffer    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
 Conjugate    Non-conjugated
 Immunogen    Recombinant human Interleukin-1 receptor-associated kinase 4 protein (1-220aa)
 Santa Cruz Alternative    Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-34469 / sc-34470 / sc-99154
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 Preparation and Storage    Shipped at 4 degree C. Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.
 ISO Certification    Manufactured in an ISO 9001:2008 Certified Laboratory.
 Other Notes    Small volumes of anti-IRAK4 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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Related Product Information for anti-IRAK4 antibody

   Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation to form the Myddosome together with IRAK2. Phosphorylates initially IRAK1, thus stimulating the kinase activity and intensive autophosphorylation of IRAK1. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates NCF1 and regulates NADPH oxidase activation after LPS stimulation suggesting a similar mechanism during microbial infections.
 Applications Tested/Suitable for anti-IRAK4 antibody   

ELISA (EIA)

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NCBI/Uniprot data below describe general gene information for IRAK4. It may not necessarily be applicable to this product.
 NCBI GI #    166795295
 NCBI GeneID    51135
 NCBI Accession #    NP_001107654.1 [Other Products]
 NCBI GenBank Nucleotide #    NM_001114182.2 [Other Products]
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 UniProt Primary Accession #    Q9NWZ3 [Other Products]
 UniProt Secondary Accession #    Q69FE1; Q8TDF7; Q9Y589 [Other Products]
 UniProt Related Accession #    Q9NWZ3 [Other Products]
 Molecular Weight    37,674 Da
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 NCBI Official Full Name    interleukin-1 receptor-associated kinase 4 isoform a
 NCBI Official Synonym Full Names    interleukin 1 receptor associated kinase 4
 NCBI Official Symbol    IRAK4 [Similar Products]
 NCBI Official Synonym Symbols   
IPD1; REN64; IRAK-4; NY-REN-64
[Similar Products]
 NCBI Protein Information    interleukin-1 receptor-associated kinase 4
 UniProt Protein Name    Interleukin-1 receptor-associated kinase 4
 UniProt Synonym Protein Names   
Renal carcinoma antigen NY-REN-64
 Protein Family    Interleukin-1 receptor-associated kinase
 UniProt Gene Name    IRAK4 [Similar Products]
 UniProt Synonym Gene Names    IRAK-4 [Similar Products]
 UniProt Entry Name    IRAK4_HUMAN
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 NCBI Summary for IRAK4    This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
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 UniProt Comments for IRAK4    IRAK4: a TKL kinase of the IRAK family. The interleukin-1 receptor-associated kinases are important mediators in the signal transduction of Toll-like receptor and IL1R family members, collectively referred to as TIRs.

Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, TKL; Protein kinase, Ser/Thr (non-receptor); TKL group; IRAK family

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: cytoplasm; cytosol; endosome membrane; extracellular space; nucleus; plasma membrane

Molecular Function: ATP binding; interleukin-1 receptor binding; magnesium ion binding; protein binding; protein kinase activity; protein serine/threonine kinase activity

Biological Process: cytokine and chemokine mediated signaling pathway; cytokine production; innate immune response; JNK cascade; MyD88-dependent toll-like receptor signaling pathway; neutrophil mediated immunity; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of smooth muscle cell proliferation; toll-like receptor 10 signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor 5 signaling pathway; toll-like receptor 9 signaling pathway; toll-like receptor signaling pathway

Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 1; Irak4 Deficiency
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 Research Articles on IRAK4    1. findings suggest that rare, functional variants in MYD88, IRAK4 or IKBKG do not significantly contribute to IPD susceptibility in adults at the population level
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IRAK4 antibodyPathways associated with anti-IRAK4 antibody
 Reference Product  PubMed Publications
 IRAK2 antibody  >214 publications with IRAK4 and IRAK2
 MYD88 antibody  >129 publications with IRAK4 and MYD88
 TLR4 antibody  >78 publications with IRAK4 and TLR4
 TRAF6 antibody  >54 publications with IRAK4 and TRAF6
 TLR2 antibody  >50 publications with IRAK4 and TLR2
 TIRAP antibody  >8 publications with IRAK4 and TIRAP
 PELI1 antibody  >5 publications with IRAK4 and PELI1
 PELI2 antibody  >1 publications with IRAK4 and PELI2
 IL1R1 antibody  >1 publications with IRAK4 and IL1R1
 Products by Pathway  Pathway Diagram
 AGE/RAGE Pathway antibodies  AGE/RAGE Pathway Diagram
 Activated TLR4 Signalling Pathway antibodies  Activated TLR4 Signalling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Chagas Disease (American Trypanosomiasis) Pathway antibodies  Chagas Disease (American Trypanosomiasis) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Diseases Associated With The TLR Signaling Cascade Pathway antibodies  Diseases Associated With The TLR Signaling Cascade Pathway Diagram
 Diseases Of Immune System Pathway antibodies  Diseases Of Immune System Pathway Diagram
Diseases associated with anti-IRAK4 antibodyOrgans/Tissues associated with anti-IRAK4 antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >97 publications with IRAK4 and Inflammation
 Immune System Diseases Antibodies  >60 publications with IRAK4 and Immune System Diseases
 Necrosis Antibodies  >58 publications with IRAK4 and Necrosis
 Death Antibodies  >41 publications with IRAK4 and Death
 Autoimmune Diseases Antibodies  >20 publications with IRAK4 and Autoimmune Diseases
 IRAK4 Deficiency Antibodies  >19 publications with IRAK4 and IRAK4 Deficiency
 Disease Models, Animal Antibodies  >15 publications with IRAK4 and Disease Models, Animal
 Nervous System Diseases Antibodies  >15 publications with IRAK4 and Nervous System Diseases
 Vascular Diseases Antibodies  >11 publications with IRAK4 and Vascular Diseases
 Liver Diseases Antibodies  >7 publications with IRAK4 and Liver Diseases
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >89 publications with IRAK4 and Blood
 Bone Antibodies  >19 publications with IRAK4 and Bone
 Lung Antibodies  >16 publications with IRAK4 and Lung
 Brain Antibodies  >14 publications with IRAK4 and Brain
 Bone Marrow Antibodies  >14 publications with IRAK4 and Bone Marrow
 Liver Antibodies  >13 publications with IRAK4 and Liver
 Skin Antibodies  >11 publications with IRAK4 and Skin
 Intestine Antibodies  >10 publications with IRAK4 and Intestine
 Vascular Antibodies  >10 publications with IRAK4 and Vascular
 Kidney Antibodies  >10 publications with IRAK4 and Kidney
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