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anti-IL10Rb antibody :: Rabbit anti-Mouse Interleukin 10 Receptor Beta (IL10Rb) Polyclonal Antibody

Scan QR to view Datasheet Catalog #    MBS2013838 (SPECIAL PROMOTION: Get FREE $5 Starbucks gift card (Maximum 5 gift cards/product). Gift card(s) will be included with shipment) anti-IL10Rb antibody
Unit / Price
0.1 mg  /  $415 +1 FREE 8GB USB
 
 Go to:   rightarrow  Product Names   rightarrow Product Info   rightarrow Accession #s   rightarrow Product Desc   rightarrow Diseases/Tissues/Pathways   rightarrow Applications   rightarrow References 
 Product Name   

Interleukin 10 Receptor Beta (IL10Rb), Polyclonal Antibody

★Popular Item★
 Also Known As   

FITC-linked Antibody to Interleukin 10 Receptor Beta (IL10Rb)

 Product Gene Name   

anti-IL10Rb antibody

[Similar Products]
 Research Use Only    For Research Use Only. Not for use in diagnostic procedures.
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 Chromosome Location    Chromosome: 21; NC_000021.8 (34638665..34669539). Location: 21q22.11
 OMIM    123889
 3D Structure    ModBase 3D Structure for Q08334
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 Clonality    Polyclonal
 Host    Rabbit
 Species Reactivity    Mouse
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 Purity/Purification    Antigen-specific affinity chromatography
 Form/Format    Supplied as solution form in 0.01m PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol
 Concentration    200ug/ml (lot specific)
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 Source    Antibody labeling
 Label    FITC
 Traits    Liquid
 Immunogen    Recombinant IL10Rb (Val42~Thr218) expressed in E.coli
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 Preparation and Storage    Storage: Avoid repeated freeze-thaw cycles.
Store at 4C for frequent use.
Aliquot and store at -20C for 12 months.
Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Note: As fluorescence can photobleach when exposed to light, so the antibody must be protected from light.
 Other Notes    Small volumes of anti-IL10Rb antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.
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 Product Categories/Family for anti-IL10Rb antibody    FITC Antibody
 Applications Tested/Suitable for anti-IL10Rb antibody   

WB; IHC; ICC; IF

 Application Notes for anti-IL10Rb antibody    Western blotting: 0.5-2g/mL
Immunohistochemistry: 5-20g/mL
Immunocytochemistry: 5-20g/mL

Optimal working dilutions must be determined by end user
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NCBI/Uniprot data below describe general gene information for IL10Rb. It may not necessarily be applicable to this product.
 NCBI GI #    371941988
 NCBI GeneID    3588
 NCBI Accession #    AEX60807.1 [Other Products]
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 UniProt Primary Accession #    Q08334 [Other Products]
 UniProt Secondary Accession #    Q9BUU4 [Other Products]
 UniProt Related Accession #    Q08334 [Other Products]
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 NCBI Official Full Name    interleukin 10 beta receptor
 NCBI Official Synonym Full Names    interleukin 10 receptor, beta
 NCBI Official Symbol    IL10RB [Similar Products]
 NCBI Official Synonym Symbols   
CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2
[Similar Products]
 NCBI Protein Information    interleukin-10 receptor subunit beta; IL-10RB; IL-10R subunit 2; IL-10R subunit beta; IL-10 receptor subunit beta; cytokine receptor class-II CRF2-4; interleukin-10 receptor subunit 2; cytokine receptor class-II member 4; cytokine receptor family 2 member 4; cytokine receptor family II, member 4
 UniProt Protein Name    Interleukin-10 receptor subunit beta
 UniProt Synonym Protein Names   
Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; CRF2-4; Interleukin-10 receptor subunit 2
 Protein Family    Interleukin-10 receptor
 UniProt Gene Name    IL10RB [Similar Products]
 UniProt Synonym Gene Names    CRFB4; D21S58; D21S66; IL-10 receptor subunit beta; IL-10R subunit beta; IL-10RB; CRF2-4; IL-10R subunit 2; IL-10R2 [Similar Products]
 UniProt Entry Name    I10R2_HUMAN
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 NCBI Summary for IL10Rb    The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
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 UniProt Comments for IL10Rb    IL10RB: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IL29. Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Belongs to the type II cytokine receptor family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: integral to membrane; plasma membrane; interleukin-28 receptor complex

Molecular Function: protein binding; interleukin-10 receptor activity; receptor activity

Biological Process: cytokine and chemokine mediated signaling pathway; immune response; signal transduction; inflammatory response; defense response to virus

Disease: Inflammatory Bowel Disease 25, Autosomal Recessive; Hepatitis B Virus, Susceptibility To
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 Research Articles on IL10Rb    1. The effects of two functional polymorphisms, type I interferon receptor 2 gene (IFNAR2)-F8S and interleukin-10 receptor subunit beta gene (IL10RB)-K47E, on chronic hepatitis B virus (HBV) infection, were investigated.
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 Precautions    All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
 Disclaimer    While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
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Products associated with anti-IL10Rb antibodyPathways associated with anti-IL10Rb antibody
 Reference Product  PubMed Publications
 IL10 antibody  >42 publications with IL10Rb and IL10
 IL10RA antibody  >13 publications with IL10Rb and IL10RA
 IL29 antibody  >5 publications with IL10Rb and IL29
 IL28B antibody  >5 publications with IL10Rb and IL28B
 IL28RA antibody  >4 publications with IL10Rb and IL28RA
 IL22 antibody  >3 publications with IL10Rb and IL22
 SOCS3 antibody  >2 publications with IL10Rb and SOCS3
 IL22RA1 antibody  >2 publications with IL10Rb and IL22RA1
 IL28A antibody  >2 publications with IL10Rb and IL28A
 JAK1 antibody  >1 publications with IL10Rb and JAK1
 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Toxoplasmosis Pathway antibodies  Toxoplasmosis Pathway Diagram
 Toxoplasmosis Pathway antibodies  Toxoplasmosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
 Tuberculosis Pathway antibodies  Tuberculosis Pathway Diagram
Diseases associated with anti-IL10Rb antibodyOrgans/Tissues associated with anti-IL10Rb antibody
 Disease Name  Pubmed Publications
 Inflammation Antibodies  >14 publications with IL10Rb and Inflammation
 Gastrointestinal Diseases Antibodies  >9 publications with IL10Rb and Gastrointestinal Diseases
 Necrosis Antibodies  >6 publications with IL10Rb and Necrosis
 Liver Diseases Antibodies  >5 publications with IL10Rb and Liver Diseases
 Hepatitis Antibodies  >5 publications with IL10Rb and Hepatitis
 Disease Models, Animal Antibodies  >3 publications with IL10Rb and Disease Models, Animal
 Hepatitis B Antibodies  >2 publications with IL10Rb and Hepatitis B
 Cardiovascular Abnormalities Antibodies  >1 publications with IL10Rb and Cardiovascular Abnormalities
 Hyperplasia Antibodies  >1 publications with IL10Rb and Hyperplasia
 Fatty Liver Antibodies  >1 publications with IL10Rb and Fatty Liver
 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >23 publications with IL10Rb and Blood
 Liver Antibodies  >5 publications with IL10Rb and Liver
 Skin Antibodies  >4 publications with IL10Rb and Skin
 Intestine Antibodies  >4 publications with IL10Rb and Intestine
 Heart Antibodies  >2 publications with IL10Rb and Heart
 Prostate Antibodies  >2 publications with IL10Rb and Prostate
 Bone Marrow Antibodies  >1 publications with IL10Rb and Bone Marrow
 Kidney Antibodies  >1 publications with IL10Rb and Kidney
 Lung Antibodies  >1 publications with IL10Rb and Lung
 Pancreas Antibodies  >1 publications with IL10Rb and Pancreas
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