EAX09841.1
[Other Products]
UniProt Secondary Accession #
UniProt Related Accession #
Molecular Weight
36,995 Da
NCBI Official Full Name
interleukin 10 receptor, beta, isoform CRA_b
NCBI Official Synonym Full Names
interleukin 10 receptor subunit beta
NCBI Official Synonym Symbols
CRFB4; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2 [Similar Products]
NCBI Protein Information
interleukin-10 receptor subunit beta
UniProt Protein Name
Interleukin-10 receptor subunit beta
UniProt Synonym Protein Names
Cytokine receptor class-II member 4; Cytokine receptor family 2 member 4; CRF2-4; Interleukin-10 receptor subunit 2; IL-10R subunit 2; IL-10R2; CD_antigen: CDw210b
UniProt Synonym Gene Names
CRFB4; D21S58; D21S66; IL-10 receptor subunit beta; IL-10R subunit beta; IL-10RB; CRF2-4; IL-10R subunit 2; IL-10R2 [Similar Products]
NCBI Summary for IL10Rb
The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
UniProt Comments for IL10Rb
IL10RB: Shared cell surface receptor required for the activation of five class 2 cytokines: IL10, IL22, IL26, IL28, and IL29. Defects in IL10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints. Belongs to the type II cytokine receptor family.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 21q22.11
Cellular Component: integral to membrane; plasma membrane
Molecular Function: interleukin-10 receptor activity; protein binding; receptor activity
Biological Process: immune response; inflammatory response; signal transduction
Disease: Hepatitis B Virus, Susceptibility To; Inflammatory Bowel Disease 25, Autosomal Recessive
Research Articles on IL10Rb
Precautions
All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.
Disclaimer
While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice. It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.
Products associated with anti-IL10Rb antibody
Pathways associated with anti-IL10Rb antibody
Diseases associated with anti-IL10Rb antibody
Organs/Tissues associated with anti-IL10Rb antibody
|